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- W1996389633 abstract "Emetine is one of the two active ingredients of syrup of ipecac which is used medicinally as antiparasitic and emetic, however little is known about its genotoxic activity. The goal of this study was to determine whether and how emetine and/or its metabolites might produce mitotic recombination using the in vivo Drosophila w/w+ eye somatic assay. A standard strain (which expresses basal levels of cytochrome P450 enzymes) and an insecticide-resistant strain (which constitutively over-expresses P450 genes) were employed. The results showed that emetine and/or its metabolites are active in the assay and that the genotoxic potential is significantly influenced in the presence of higher than normal concentrations of P450." @default.
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- W1996389633 date "2007-09-13" @default.
- W1996389633 modified "2023-10-18" @default.
- W1996389633 title "Emetine and/or its Metabolites are Genotoxic in Somatic Cells ofDrosophila Melanogaster" @default.
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- W1996389633 doi "https://doi.org/10.1080/10937400601171241" @default.
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