FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996392248> ?p ?o ?g. }

• W1996392248 endingPage "540" @default.
• W1996392248 startingPage "534" @default.
• W1996392248 abstract "To determine sarcolemmal Na+/H+ exchanger (NHE) activity and expression in human ventricular myocardium.Although the sarcolemmal NHE has been implicated in various physiological and pathophysiological phenomena in animal studies, its activity and expression in human myocardium have not been studied.Ventricular myocardium was obtained from unused donor hearts with acute myocardial dysfunction (n = 5) and recipient hearts with chronic end stage heart failure (n = 11) through a transplantation program. Intracellular pH (pHi) was monitored in enzymatically isolated single ventricular myocytes by microepifluorescence. As the index of sarcolemmal NHE activity, the rate of H+ efflux at a pHi of 6.90 J(H6.9)) was determined after the induction of intracellular acidosis in bicarbonate-free medium. Na+/H+ exchanger isoform 1 (NHE1) expression in ventricular myocardium was determined by immunoblot analysis.Human ventricular myocytes exhibited readily detectable sarcolemmal NHE activity after the induction of intracellular acidosis, and this activity was suppressed by the NHE1-selective inhibitor HOE-642 (cariporide) at 1 micromol/L. Sarcolemmal NHE activity of myocytes was significantly greater in recipient hearts (JH6.9 = 1.95+/-0.18 mmol/L/min) than it was in unused donor hearts (J(H6.9 = 1.06+/-0.15 mmol/L/min). In contrast, NHE1 protein was expressed in similar abundance in ventricular myocardium from both recipient and unused donor hearts.Sarcolemmal NHE activity of human ventricular myocytes arises from the NHE1 isoform and is inhibited by HOE-642. Sarcolemmal NHE activity is significantly greater in recipient hearts with chronic end-stage heart failure than it is in unused donor hearts, and this difference is likely to arise from altered posttranslational regulation." @default.
• W1996392248 created "2016-06-24" @default.
• W1996392248 creator A5000460366 @default.
• W1996392248 creator A5004481799 @default.
• W1996392248 creator A5005153787 @default.
• W1996392248 creator A5055266997 @default.
• W1996392248 date "2000-08-01" @default.
• W1996392248 modified "2023-09-25" @default.
• W1996392248 title "Sarcolemmal Na+/H+ exchanger activity and expression in human ventricular myocardium" @default.
• W1996392248 cites W1810452607 @default.
• W1996392248 cites W1981398898 @default.
• W1996392248 cites W1981932175 @default.
• W1996392248 cites W1983934105 @default.
• W1996392248 cites W1997268902 @default.
• W1996392248 cites W2007305364 @default.
• W1996392248 cites W2013223126 @default.
• W1996392248 cites W2017817977 @default.
• W1996392248 cites W2020221117 @default.
• W1996392248 cites W2028376645 @default.
• W1996392248 cites W2035522704 @default.
• W1996392248 cites W2038437379 @default.
• W1996392248 cites W2042943866 @default.
• W1996392248 cites W2042997162 @default.
• W1996392248 cites W2053135322 @default.
• W1996392248 cites W2058117374 @default.
• W1996392248 cites W2060510699 @default.
• W1996392248 cites W2065235357 @default.
• W1996392248 cites W2066119862 @default.
• W1996392248 cites W2079047912 @default.
• W1996392248 cites W2081230957 @default.
• W1996392248 cites W2093006711 @default.
• W1996392248 cites W2094712994 @default.
• W1996392248 cites W2096939668 @default.
• W1996392248 cites W2102493498 @default.
• W1996392248 cites W2117631539 @default.
• W1996392248 cites W2121761723 @default.
• W1996392248 cites W2124285310 @default.
• W1996392248 cites W2126016824 @default.
• W1996392248 cites W2143745586 @default.
• W1996392248 cites W2144301997 @default.
• W1996392248 cites W2151783154 @default.
• W1996392248 cites W2154005496 @default.
• W1996392248 cites W2158452359 @default.
• W1996392248 cites W2164678960 @default.
• W1996392248 cites W2165017574 @default.
• W1996392248 cites W2167937030 @default.
• W1996392248 cites W2412936367 @default.
• W1996392248 cites W4237107761 @default.
• W1996392248 cites W4248009949 @default.
• W1996392248 cites W4298077841 @default.
• W1996392248 doi "https://doi.org/10.1016/s0735-1097(00)00730-0" @default.
• W1996392248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10933369" @default.
• W1996392248 hasPublicationYear "2000" @default.
• W1996392248 type Work @default.
• W1996392248 sameAs 1996392248 @default.
• W1996392248 citedByCount "112" @default.
• W1996392248 countsByYear W19963922482012 @default.
• W1996392248 countsByYear W19963922482013 @default.
• W1996392248 countsByYear W19963922482014 @default.
• W1996392248 countsByYear W19963922482015 @default.
• W1996392248 countsByYear W19963922482016 @default.
• W1996392248 countsByYear W19963922482017 @default.
• W1996392248 countsByYear W19963922482018 @default.
• W1996392248 countsByYear W19963922482019 @default.
• W1996392248 countsByYear W19963922482020 @default.
• W1996392248 countsByYear W19963922482021 @default.
• W1996392248 countsByYear W19963922482022 @default.
• W1996392248 countsByYear W19963922482023 @default.
• W1996392248 crossrefType "journal-article" @default.
• W1996392248 hasAuthorship W1996392248A5000460366 @default.
• W1996392248 hasAuthorship W1996392248A5004481799 @default.
• W1996392248 hasAuthorship W1996392248A5005153787 @default.
• W1996392248 hasAuthorship W1996392248A5055266997 @default.
• W1996392248 hasConcept C114574056 @default.
• W1996392248 hasConcept C126322002 @default.
• W1996392248 hasConcept C134018914 @default.
• W1996392248 hasConcept C134897140 @default.
• W1996392248 hasConcept C164705383 @default.
• W1996392248 hasConcept C178790620 @default.
• W1996392248 hasConcept C185592680 @default.
• W1996392248 hasConcept C199096232 @default.
• W1996392248 hasConcept C207200792 @default.
• W1996392248 hasConcept C2778198053 @default.
• W1996392248 hasConcept C2778553927 @default.
• W1996392248 hasConcept C537181965 @default.
• W1996392248 hasConcept C55493867 @default.
• W1996392248 hasConcept C71924100 @default.
• W1996392248 hasConcept C79879829 @default.
• W1996392248 hasConceptScore W1996392248C114574056 @default.
• W1996392248 hasConceptScore W1996392248C126322002 @default.
• W1996392248 hasConceptScore W1996392248C134018914 @default.
• W1996392248 hasConceptScore W1996392248C134897140 @default.
• W1996392248 hasConceptScore W1996392248C164705383 @default.
• W1996392248 hasConceptScore W1996392248C178790620 @default.
• W1996392248 hasConceptScore W1996392248C185592680 @default.
• W1996392248 hasConceptScore W1996392248C199096232 @default.
• W1996392248 hasConceptScore W1996392248C207200792 @default.
• W1996392248 hasConceptScore W1996392248C2778198053 @default.

• next