FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996394857> ?p ?o ?g. }

• W1996394857 endingPage "459" @default.
• W1996394857 startingPage "451" @default.
• W1996394857 abstract "Sodium stibogluconate (SSG), an inhibitor of SHP-1 that negatively regulates cytokine signaling and immunity, suppressed growth of murine Renca tumors in combination with interleukin-2 (IL-2) via a T-cell-dependent mechanism. The ability of SSG to interact with IL-2 in activating primary human immune cells was evaluated herein by assessing its induction of interferon (IFN)-gamma(+) TH1 cells in human peripheral blood in vitro. The significance of IFN-gamma(+) cells was also investigated by assessing SSG/IL-2 antitumor activity in wild-type and IFN-gamma(-/-) mice. IFN-gamma(+) cells but not IL-5(+) cells were induced markedly (9.1x) in healthy peripheral blood by SSG/IL-2 in contrast to the modest induction by SSG alone (2.1x) at its clinically achievable dose (20 microg/mL) or by IL-2 (3.1x) at its C(max) of low-dose schedule (30 IU/mL). SSG at a higher dose (100 microg/mL) was less effective alone (1.5x) or in combination with IL-2 (7.8x). Peripheral IFN-gamma(+) cells were induced after 4 or 16 h treatment with SSG/IL-2 within CD4(+) and CD8(+) lymphocytes coincided with heightened CD69 expression (approximately 3-4x). SSG/IL-2 was also more effective than the single agents in inducing IFN-gamma(+) cells in the peripheral blood of melanoma patients, whose basal IFN-gamma(+) cell levels were approximately 5% of healthy controls. Renca tumor growth was inhibited by SSG/IL-2 in wild-type but not IFN-gamma(-/-) mice. These results demonstrate SSG interactions with IL-2 in vitro to activate key antitumor immune cells in peripheral blood of healthy and melanoma donors, providing further evidence for proof of concept clinical trials for effecting augmentation of IL-2 through inhibiting negative regulatory protein tyrosine phosphatases." @default.
• W1996394857 created "2016-06-24" @default.
• W1996394857 creator A5027881172 @default.
• W1996394857 creator A5056562780 @default.
• W1996394857 creator A5084645490 @default.
• W1996394857 date "2009-08-01" @default.
• W1996394857 modified "2023-09-23" @default.
• W1996394857 title "Interferon-γ Is Induced in Human Peripheral Blood Immune Cells<i>In Vitro</i>by Sodium Stibogluconate/Interleukin-2 and Mediates Its Antitumor Activity<i>In Vivo</i>" @default.
• W1996394857 cites W1488372279 @default.
• W1996394857 cites W1497476164 @default.
• W1996394857 cites W1510932913 @default.
• W1996394857 cites W1564486041 @default.
• W1996394857 cites W1612419598 @default.
• W1996394857 cites W1864739484 @default.
• W1996394857 cites W1969918683 @default.
• W1996394857 cites W1974137477 @default.
• W1996394857 cites W1975290673 @default.
• W1996394857 cites W1981912238 @default.
• W1996394857 cites W1993948601 @default.
• W1996394857 cites W1999809189 @default.
• W1996394857 cites W2000621937 @default.
• W1996394857 cites W2000813775 @default.
• W1996394857 cites W2031980581 @default.
• W1996394857 cites W2034881442 @default.
• W1996394857 cites W2038740130 @default.
• W1996394857 cites W2042122259 @default.
• W1996394857 cites W2072271751 @default.
• W1996394857 cites W2074850559 @default.
• W1996394857 cites W2077647945 @default.
• W1996394857 cites W2097431036 @default.
• W1996394857 cites W2100869656 @default.
• W1996394857 cites W2112229251 @default.
• W1996394857 cites W2116177733 @default.
• W1996394857 cites W2130708019 @default.
• W1996394857 cites W2135678986 @default.
• W1996394857 cites W2138589906 @default.
• W1996394857 cites W2156408558 @default.
• W1996394857 cites W2164355279 @default.
• W1996394857 cites W2167017590 @default.
• W1996394857 cites W2168946125 @default.
• W1996394857 cites W2312804644 @default.
• W1996394857 cites W2329648702 @default.
• W1996394857 cites W2398229687 @default.
• W1996394857 cites W4244091585 @default.
• W1996394857 doi "https://doi.org/10.1089/jir.2008.0061" @default.
• W1996394857 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2956636" @default.
• W1996394857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19514839" @default.
• W1996394857 hasPublicationYear "2009" @default.
• W1996394857 type Work @default.
• W1996394857 sameAs 1996394857 @default.
• W1996394857 citedByCount "11" @default.
• W1996394857 countsByYear W19963948572012 @default.
• W1996394857 countsByYear W19963948572014 @default.
• W1996394857 countsByYear W19963948572015 @default.
• W1996394857 countsByYear W19963948572019 @default.
• W1996394857 countsByYear W19963948572020 @default.
• W1996394857 countsByYear W19963948572022 @default.
• W1996394857 crossrefType "journal-article" @default.
• W1996394857 hasAuthorship W1996394857A5027881172 @default.
• W1996394857 hasAuthorship W1996394857A5056562780 @default.
• W1996394857 hasAuthorship W1996394857A5084645490 @default.
• W1996394857 hasBestOaLocation W19963948572 @default.
• W1996394857 hasConcept C150903083 @default.
• W1996394857 hasConcept C167672396 @default.
• W1996394857 hasConcept C191732599 @default.
• W1996394857 hasConcept C202751555 @default.
• W1996394857 hasConcept C203014093 @default.
• W1996394857 hasConcept C207001950 @default.
• W1996394857 hasConcept C2777371288 @default.
• W1996394857 hasConcept C2778690821 @default.
• W1996394857 hasConcept C2780841837 @default.
• W1996394857 hasConcept C55493867 @default.
• W1996394857 hasConcept C71924100 @default.
• W1996394857 hasConcept C74172505 @default.
• W1996394857 hasConcept C86803240 @default.
• W1996394857 hasConcept C8891405 @default.
• W1996394857 hasConcept C98274493 @default.
• W1996394857 hasConceptScore W1996394857C150903083 @default.
• W1996394857 hasConceptScore W1996394857C167672396 @default.
• W1996394857 hasConceptScore W1996394857C191732599 @default.
• W1996394857 hasConceptScore W1996394857C202751555 @default.
• W1996394857 hasConceptScore W1996394857C203014093 @default.
• W1996394857 hasConceptScore W1996394857C207001950 @default.
• W1996394857 hasConceptScore W1996394857C2777371288 @default.
• W1996394857 hasConceptScore W1996394857C2778690821 @default.
• W1996394857 hasConceptScore W1996394857C2780841837 @default.
• W1996394857 hasConceptScore W1996394857C55493867 @default.
• W1996394857 hasConceptScore W1996394857C71924100 @default.
• W1996394857 hasConceptScore W1996394857C74172505 @default.
• W1996394857 hasConceptScore W1996394857C86803240 @default.
• W1996394857 hasConceptScore W1996394857C8891405 @default.
• W1996394857 hasConceptScore W1996394857C98274493 @default.
• W1996394857 hasIssue "8" @default.
• W1996394857 hasLocation W19963948571 @default.
• W1996394857 hasLocation W19963948572 @default.
• W1996394857 hasLocation W19963948573 @default.
• W1996394857 hasLocation W19963948574 @default.
• W1996394857 hasOpenAccess W1996394857 @default.

• next