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- W1996408717 endingPage "e17748" @default.
- W1996408717 startingPage "e17748" @default.
- W1996408717 abstract "Glycoprotein D (gD-2) is the entry receptor of herpes simplex virus 2 (HSV-2), and is the immunogen in the pharmaceutical industry's lead HSV-2 vaccine candidate. Efforts to prevent genital herpes using gD-2 subunit vaccines have been ongoing for 20 years at a cost in excess of $100 million. To date, gD-2 vaccines have yielded equivocal protection in clinical trials. Therefore, using a small animal model, we sought to determine if a live-attenuated HSV-2 ICP0− virus would elicit better protection against genital herpes than a gD-2 subunit vaccine. Mice immunized with gD-2 and a potent adjuvant (alum+monophosphoryl lipid A) produced high titers of gD-2 antibody. While gD-2-immunized mice possessed significant resistance to HSV-2, only 3 of 45 gD-2-immunized mice survived an overwhelming challenge of the vagina or eyes with wild-type HSV-2 (MS strain). In contrast, 114 of 115 mice immunized with a live HSV-2 ICP0− virus, 0ΔNLS, survived the same HSV-2 MS challenges. Likewise, 0ΔNLS-immunized mice shed an average 125-fold less HSV-2 MS challenge virus per vagina relative to gD-2-immunized mice. In vivo imaging demonstrated that a luciferase-expressing HSV-2 challenge virus failed to establish a detectable infection in 0ΔNLS-immunized mice, whereas the same virus readily infected naïve and gD-2-immunized mice. Collectively, these results suggest that a HSV-2 vaccine might be more likely to prevent genital herpes if it contained a live-attenuated HSV-2 virus rather than a single HSV-2 protein." @default.
- W1996408717 created "2016-06-24" @default.
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- W1996408717 creator A5067676121 @default.
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- W1996408717 date "2011-03-11" @default.
- W1996408717 modified "2023-10-18" @default.
- W1996408717 title "A Live-Attenuated HSV-2 ICP0− Virus Elicits 10 to 100 Times Greater Protection against Genital Herpes than a Glycoprotein D Subunit Vaccine" @default.
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- W1996408717 doi "https://doi.org/10.1371/journal.pone.0017748" @default.
- W1996408717 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3055896" @default.
- W1996408717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21412438" @default.
- W1996408717 hasPublicationYear "2011" @default.
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