FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996409611> ?p ?o ?g. }

• W1996409611 abstract "Streptococcus suis Dpr is an iron-binding protein involved in oxidative stress resistance. It belongs to the bacterial Dps protein family whose members form dodecameric assemblies. Previous studies have shown that zinc and terbium inhibit iron incorporation in Listeria innocua Dps protein. In order to gain structural insights into the inhibitory effect of zinc and terbium, the crystal structures of Streptococcus suis Dpr complexes with these ions were determined at 1.8 A and 2.1 A, respectively. Both ions were found to bind at the ferroxidase center and in the same location as iron. In addition, a novel zinc-binding site formed by His40 and His44 was identified. Both His residues were found to be present within all known Streptococcus suis Dpr variants and in Streptococcus pneumoniae, Streptococcus gordonii, and Streptococcus sanguinis Dpr proteins. Amino acid sequence alignment of Dpr with other Dps family members revealed that His44 is highly conserved, in contrast to His40. The inhibitory effect of zinc and terbium on iron oxidation in Dpr was studied in vitro, and it was found that both ions at concentrations >0.2 mM almost completely abolish iron binding. These results provide a structural basis for the inhibitory effect of zinc and terbium in the Dps family of proteins, and suggest a potential role of the Dps proteins in zinc detoxification mechanisms involving the second zinc-binding site." @default.
• W1996409611 created "2016-06-24" @default.
• W1996409611 creator A5012883316 @default.
• W1996409611 creator A5014875932 @default.
• W1996409611 creator A5022537495 @default.
• W1996409611 creator A5028507653 @default.
• W1996409611 creator A5032011846 @default.
• W1996409611 creator A5057196228 @default.
• W1996409611 creator A5077096784 @default.
• W1996409611 creator A5085252279 @default.
• W1996409611 date "2008-09-01" @default.
• W1996409611 modified "2023-09-27" @default.
• W1996409611 title "Structural basis of the zinc- and terbium-mediated inhibition of ferroxidase activity in Dps ferritin-like proteins" @default.
• W1996409611 cites W1574331916 @default.
• W1996409611 cites W1581168206 @default.
• W1996409611 cites W1965117674 @default.
• W1996409611 cites W1967480000 @default.
• W1996409611 cites W1967932621 @default.
• W1996409611 cites W1969756310 @default.
• W1996409611 cites W1970901062 @default.
• W1996409611 cites W1982945635 @default.
• W1996409611 cites W1985629904 @default.
• W1996409611 cites W1987498682 @default.
• W1996409611 cites W1994342014 @default.
• W1996409611 cites W1995803883 @default.
• W1996409611 cites W1999077713 @default.
• W1996409611 cites W2000840258 @default.
• W1996409611 cites W2001715545 @default.
• W1996409611 cites W2013910882 @default.
• W1996409611 cites W2016766531 @default.
• W1996409611 cites W2021052479 @default.
• W1996409611 cites W2021641202 @default.
• W1996409611 cites W2022022844 @default.
• W1996409611 cites W2036240480 @default.
• W1996409611 cites W2038840577 @default.
• W1996409611 cites W2041530643 @default.
• W1996409611 cites W2042976887 @default.
• W1996409611 cites W2051498513 @default.
• W1996409611 cites W2059219903 @default.
• W1996409611 cites W2061736316 @default.
• W1996409611 cites W2070019521 @default.
• W1996409611 cites W2075853257 @default.
• W1996409611 cites W2076948376 @default.
• W1996409611 cites W2082986346 @default.
• W1996409611 cites W2086381657 @default.
• W1996409611 cites W2086567353 @default.
• W1996409611 cites W2090403298 @default.
• W1996409611 cites W2098617519 @default.
• W1996409611 cites W2125100569 @default.
• W1996409611 cites W2128996981 @default.
• W1996409611 cites W2135669554 @default.
• W1996409611 cites W2142440390 @default.
• W1996409611 cites W2142459127 @default.
• W1996409611 cites W2144081223 @default.
• W1996409611 cites W274005068 @default.
• W1996409611 doi "https://doi.org/10.1110/ps.036236.108" @default.
• W1996409611 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2525527" @default.
• W1996409611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18552126" @default.
• W1996409611 hasPublicationYear "2008" @default.
• W1996409611 type Work @default.
• W1996409611 sameAs 1996409611 @default.
• W1996409611 citedByCount "17" @default.
• W1996409611 countsByYear W19964096112012 @default.
• W1996409611 countsByYear W19964096112014 @default.
• W1996409611 countsByYear W19964096112016 @default.
• W1996409611 countsByYear W19964096112018 @default.
• W1996409611 countsByYear W19964096112019 @default.
• W1996409611 countsByYear W19964096112020 @default.
• W1996409611 countsByYear W19964096112021 @default.
• W1996409611 countsByYear W19964096112022 @default.
• W1996409611 countsByYear W19964096112023 @default.
• W1996409611 crossrefType "journal-article" @default.
• W1996409611 hasAuthorship W1996409611A5012883316 @default.
• W1996409611 hasAuthorship W1996409611A5014875932 @default.
• W1996409611 hasAuthorship W1996409611A5022537495 @default.
• W1996409611 hasAuthorship W1996409611A5028507653 @default.
• W1996409611 hasAuthorship W1996409611A5032011846 @default.
• W1996409611 hasAuthorship W1996409611A5057196228 @default.
• W1996409611 hasAuthorship W1996409611A5077096784 @default.
• W1996409611 hasAuthorship W1996409611A5085252279 @default.
• W1996409611 hasBestOaLocation W19964096112 @default.
• W1996409611 hasConcept C145148216 @default.
• W1996409611 hasConcept C178790620 @default.
• W1996409611 hasConcept C185592680 @default.
• W1996409611 hasConcept C2778319317 @default.
• W1996409611 hasConcept C2778663903 @default.
• W1996409611 hasConcept C2780368718 @default.
• W1996409611 hasConcept C28452662 @default.
• W1996409611 hasConcept C501593827 @default.
• W1996409611 hasConcept C535196362 @default.
• W1996409611 hasConcept C549856995 @default.
• W1996409611 hasConcept C55493867 @default.
• W1996409611 hasConceptScore W1996409611C145148216 @default.
• W1996409611 hasConceptScore W1996409611C178790620 @default.
• W1996409611 hasConceptScore W1996409611C185592680 @default.
• W1996409611 hasConceptScore W1996409611C2778319317 @default.
• W1996409611 hasConceptScore W1996409611C2778663903 @default.
• W1996409611 hasConceptScore W1996409611C2780368718 @default.
• W1996409611 hasConceptScore W1996409611C28452662 @default.
• W1996409611 hasConceptScore W1996409611C501593827 @default.

• next