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- W1996420004 abstract "Forward genetic screens for mutants in which specific biological processes are disrupted are a key strength of model systems like C.elegans or Drosophila. However, the road from isolating a phenotype-causing mutant strain to identifying the molecular nature of the genetic change, most often as little as a single point mutation, is cumbersome, traditionally involving timeconsuming genetic mapping strategies. We have recently shown in a proof-of-principle study that conventional mapping steps can be shortcut through the use of whole genome sequencing (WGS) with massively parallel, deep-sequencing technology 1,2 (Suppl. Table 1). A similar proof-of-principle approach has proven successful for Drosophila mutant identification as well 3." @default.
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- W1996420004 date "2009-07-20" @default.
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- W1996420004 title "MAQGene: software to facilitate C. elegans mutant genome sequence analysis" @default.
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- W1996420004 doi "https://doi.org/10.1038/nmeth.f.260" @default.
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