Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996424511> ?p ?o ?g. }
- W1996424511 endingPage "32" @default.
- W1996424511 startingPage "24" @default.
- W1996424511 abstract "Essential oils are complex mixtures of odorous and volatile compounds derived from secondary plant metabolism. They can be isolated from many plants by mechanical pressing or hydro- and steam-distillation and are known to induce a wide range of biological effects through their antibacterial, antifungal, cytotoxic, antioxidant and antimutagenic activities. In order to explore their beneficial properties on human skin cells, we investigated the effects of an essential oil from rosewood Aniba rosaeodora (REO) on the human epidermoid carcinoma cell line A431, on immortal HaCaT cells thought to represent an early stage of skin carcinogenesis, on transformed normal HEK001 keratinocytes and on primary normal NHEK keratinocytes. In a defined range of concentrations, REO selectively killed A431 and HaCaT cells. The same treatments had only a minor cytotoxic effect on HEK001 and NHEK cells. Preferentially in A431 and HaCaT cells, REO triggered the production of reactive oxygen species, induced depolarization of the mitochondrial membrane and caused caspase-dependent cell death characterized by phosphatidylserine externalization, an early marker of apoptosis. Both intrinsic and extrinsic apoptotic pathways were implicated in REO-induced cell death. The identification of selective induction of apoptosis in precancerous and cancerous skin cells by REO highlights the potential anticancer activity of this essential oil." @default.
- W1996424511 created "2016-06-24" @default.
- W1996424511 creator A5012684055 @default.
- W1996424511 creator A5013327816 @default.
- W1996424511 creator A5022024949 @default.
- W1996424511 creator A5032021807 @default.
- W1996424511 creator A5039621042 @default.
- W1996424511 creator A5067410562 @default.
- W1996424511 creator A5076348068 @default.
- W1996424511 creator A5081458575 @default.
- W1996424511 creator A5082509799 @default.
- W1996424511 date "2011-01-01" @default.
- W1996424511 modified "2023-10-12" @default.
- W1996424511 title "Selective cytotoxicity of Aniba rosaeodora essential oil towards epidermoid cancer cells through induction of apoptosis" @default.
- W1996424511 cites W1963801361 @default.
- W1996424511 cites W1967894078 @default.
- W1996424511 cites W1970748590 @default.
- W1996424511 cites W1971263182 @default.
- W1996424511 cites W1977258127 @default.
- W1996424511 cites W1978058355 @default.
- W1996424511 cites W1978734074 @default.
- W1996424511 cites W1981823569 @default.
- W1996424511 cites W1983108385 @default.
- W1996424511 cites W1984459650 @default.
- W1996424511 cites W1992292321 @default.
- W1996424511 cites W1998336994 @default.
- W1996424511 cites W2001661502 @default.
- W1996424511 cites W2003083090 @default.
- W1996424511 cites W2005441809 @default.
- W1996424511 cites W2021844354 @default.
- W1996424511 cites W2025622702 @default.
- W1996424511 cites W2027443731 @default.
- W1996424511 cites W2036009794 @default.
- W1996424511 cites W2040898244 @default.
- W1996424511 cites W2043411643 @default.
- W1996424511 cites W2057479239 @default.
- W1996424511 cites W2072225623 @default.
- W1996424511 cites W2073683448 @default.
- W1996424511 cites W2075488453 @default.
- W1996424511 cites W2079097764 @default.
- W1996424511 cites W2079236383 @default.
- W1996424511 cites W2080223716 @default.
- W1996424511 cites W2099848441 @default.
- W1996424511 cites W2122910156 @default.
- W1996424511 cites W2143464311 @default.
- W1996424511 cites W2150315067 @default.
- W1996424511 cites W2152118759 @default.
- W1996424511 cites W2153010844 @default.
- W1996424511 cites W2165997736 @default.
- W1996424511 cites W2189006261 @default.
- W1996424511 cites W4243519405 @default.
- W1996424511 cites W4386007350 @default.
- W1996424511 cites W85124676 @default.
- W1996424511 doi "https://doi.org/10.1016/j.mrgentox.2010.10.009" @default.
- W1996424511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21070863" @default.
- W1996424511 hasPublicationYear "2011" @default.
- W1996424511 type Work @default.
- W1996424511 sameAs 1996424511 @default.
- W1996424511 citedByCount "41" @default.
- W1996424511 countsByYear W19964245112013 @default.
- W1996424511 countsByYear W19964245112014 @default.
- W1996424511 countsByYear W19964245112015 @default.
- W1996424511 countsByYear W19964245112016 @default.
- W1996424511 countsByYear W19964245112017 @default.
- W1996424511 countsByYear W19964245112018 @default.
- W1996424511 countsByYear W19964245112019 @default.
- W1996424511 countsByYear W19964245112020 @default.
- W1996424511 countsByYear W19964245112021 @default.
- W1996424511 countsByYear W19964245112022 @default.
- W1996424511 countsByYear W19964245112023 @default.
- W1996424511 crossrefType "journal-article" @default.
- W1996424511 hasAuthorship W1996424511A5012684055 @default.
- W1996424511 hasAuthorship W1996424511A5013327816 @default.
- W1996424511 hasAuthorship W1996424511A5022024949 @default.
- W1996424511 hasAuthorship W1996424511A5032021807 @default.
- W1996424511 hasAuthorship W1996424511A5039621042 @default.
- W1996424511 hasAuthorship W1996424511A5067410562 @default.
- W1996424511 hasAuthorship W1996424511A5076348068 @default.
- W1996424511 hasAuthorship W1996424511A5081458575 @default.
- W1996424511 hasAuthorship W1996424511A5082509799 @default.
- W1996424511 hasConcept C104317684 @default.
- W1996424511 hasConcept C109316439 @default.
- W1996424511 hasConcept C118995209 @default.
- W1996424511 hasConcept C121608353 @default.
- W1996424511 hasConcept C154317977 @default.
- W1996424511 hasConcept C185592680 @default.
- W1996424511 hasConcept C190283241 @default.
- W1996424511 hasConcept C202751555 @default.
- W1996424511 hasConcept C2781018059 @default.
- W1996424511 hasConcept C29537977 @default.
- W1996424511 hasConcept C2994460389 @default.
- W1996424511 hasConcept C31573885 @default.
- W1996424511 hasConcept C47170353 @default.
- W1996424511 hasConcept C48349386 @default.
- W1996424511 hasConcept C54355233 @default.
- W1996424511 hasConcept C55493867 @default.
- W1996424511 hasConcept C555283112 @default.
- W1996424511 hasConcept C81885089 @default.