Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996441807> ?p ?o ?g. }
- W1996441807 endingPage "1959" @default.
- W1996441807 startingPage "1945" @default.
- W1996441807 abstract "Despite significant improvements in the medical, percutaneous, and surgical management, numerous patients are first seen with non-revascularizable coronary artery disease (CAD). The growth of new blood vessels to improve myocardial perfusion (i.e., therapeutic angiogenesis) is an attractive treatment option for these patients. However, the successes of angiogenic therapy, observed in preclinical studies, have not been realized in clinical trials. Increasing evidence suggests that this discrepancy between animal and human studies may be due to the nature of the substrate, or the molecular and cellular environment within which the angiogenic agent acts. Antiangiogenic influences, including endothelial dysfunction, hypercholesterolemia, and diabetes, are present in virtually all patients with advanced CAD. Recent studies have better characterized the abnormalities associated with these disease states, providing novel targets for intervention. These substrate-modifying interventions can potentially enhance the response to protein-, gene-, or cell-based angiogenic therapy. In this review, we discuss key aspects of the angiogenic process and the pathophysiologic and molecular mechanisms that contribute to an impaired angiogenic response in the setting of endothelial dysfunction, hypercholesterolemia, and diabetes, with a focus on the role of oxidative stress. Last, we briefly explore substrate modifying agents that have been evaluated in preclinical and clinical studies to improve the angiogenic response. Antioxid. Redox Signal. 11, 1945–1959." @default.
- W1996441807 created "2016-06-24" @default.
- W1996441807 creator A5012657061 @default.
- W1996441807 creator A5063893726 @default.
- W1996441807 date "2009-08-01" @default.
- W1996441807 modified "2023-10-17" @default.
- W1996441807 title "Therapeutic Angiogenesis in Diabetes and Hypercholesterolemia: Influence of Oxidative Stress" @default.
- W1996441807 cites W1495287184 @default.
- W1996441807 cites W1554194284 @default.
- W1996441807 cites W1783580437 @default.
- W1996441807 cites W1964192770 @default.
- W1996441807 cites W1965144118 @default.
- W1996441807 cites W1976616659 @default.
- W1996441807 cites W1977714181 @default.
- W1996441807 cites W1982556125 @default.
- W1996441807 cites W1990800912 @default.
- W1996441807 cites W1992063755 @default.
- W1996441807 cites W1992644466 @default.
- W1996441807 cites W1993387626 @default.
- W1996441807 cites W1993966328 @default.
- W1996441807 cites W1994195439 @default.
- W1996441807 cites W1995159508 @default.
- W1996441807 cites W1995827857 @default.
- W1996441807 cites W1996537616 @default.
- W1996441807 cites W1998725500 @default.
- W1996441807 cites W2000331403 @default.
- W1996441807 cites W2001365045 @default.
- W1996441807 cites W2004297042 @default.
- W1996441807 cites W2005451208 @default.
- W1996441807 cites W2006847107 @default.
- W1996441807 cites W2008230132 @default.
- W1996441807 cites W2009029293 @default.
- W1996441807 cites W2009861854 @default.
- W1996441807 cites W2009889130 @default.
- W1996441807 cites W2010687118 @default.
- W1996441807 cites W2011470732 @default.
- W1996441807 cites W2011677357 @default.
- W1996441807 cites W2016847030 @default.
- W1996441807 cites W2023596297 @default.
- W1996441807 cites W2024348691 @default.
- W1996441807 cites W2025445144 @default.
- W1996441807 cites W2025640298 @default.
- W1996441807 cites W2028032256 @default.
- W1996441807 cites W2030287913 @default.
- W1996441807 cites W2032767070 @default.
- W1996441807 cites W2034463755 @default.
- W1996441807 cites W2035059839 @default.
- W1996441807 cites W2036021417 @default.
- W1996441807 cites W2039666558 @default.
- W1996441807 cites W2041643473 @default.
- W1996441807 cites W2044568120 @default.
- W1996441807 cites W2045405791 @default.
- W1996441807 cites W2049796621 @default.
- W1996441807 cites W2050517931 @default.
- W1996441807 cites W2051877289 @default.
- W1996441807 cites W2054908811 @default.
- W1996441807 cites W2056148198 @default.
- W1996441807 cites W2057571154 @default.
- W1996441807 cites W2058496994 @default.
- W1996441807 cites W2065126093 @default.
- W1996441807 cites W2072868334 @default.
- W1996441807 cites W2076896175 @default.
- W1996441807 cites W2079014491 @default.
- W1996441807 cites W2084151086 @default.
- W1996441807 cites W2085493921 @default.
- W1996441807 cites W2085738449 @default.
- W1996441807 cites W2086719224 @default.
- W1996441807 cites W2086974586 @default.
- W1996441807 cites W2089295762 @default.
- W1996441807 cites W2092505217 @default.
- W1996441807 cites W2092859490 @default.
- W1996441807 cites W2093734169 @default.
- W1996441807 cites W2097837724 @default.
- W1996441807 cites W2098444281 @default.
- W1996441807 cites W2102047825 @default.
- W1996441807 cites W2103227975 @default.
- W1996441807 cites W2105331895 @default.
- W1996441807 cites W2107340439 @default.
- W1996441807 cites W2112439550 @default.
- W1996441807 cites W2112481821 @default.
- W1996441807 cites W2113291443 @default.
- W1996441807 cites W2115177689 @default.
- W1996441807 cites W2115337529 @default.
- W1996441807 cites W2116509317 @default.
- W1996441807 cites W2120448695 @default.
- W1996441807 cites W2124665258 @default.
- W1996441807 cites W2124715674 @default.
- W1996441807 cites W2125114619 @default.
- W1996441807 cites W2125150769 @default.
- W1996441807 cites W2125439746 @default.
- W1996441807 cites W2131798870 @default.
- W1996441807 cites W2133353133 @default.
- W1996441807 cites W2134178185 @default.
- W1996441807 cites W2136812723 @default.
- W1996441807 cites W2137982969 @default.
- W1996441807 cites W2138369468 @default.
- W1996441807 cites W2138736529 @default.
- W1996441807 cites W2139289160 @default.