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• W1996453073 abstract "We appreciate the interest of Emin Akgul et al. in our research on mtDNA mutations in exhaled breath condensate in patients with lung cancer [[1]Ai S.S.Y. Hsu K. Herbert C. et al.Mitochondrial DNA mutations in exhaled breath condensate of patients with lung cancer.Respir Med. 2013; 13: S0954-S6111Google Scholar]. As the authors of this letter indicated, large scale deletions and mtDNA depletions have also been implicated in the pathogenesis of cancer development as in given examples of Kearn–Sayre syndrome and Alper's syndrome, and furthermore that these have been investigated in studies of lung cancer. Our study was intended to be a pilot study looking at mtDNA changes in EBC of lung cancer patients, and we chose the D-loop as a region to study as it is a hotspot of point mutations in a variety of cancers, including lung cancer [[2]Suzuki M. Toyooka S. Miyajima K. et al.Alterations in the mitochondrial displacement loop in lung cancers.Clin Cancer Res. 2003; 9: 5636-5641PubMed Google Scholar]. Furthermore, previous literature has suggested that frequency of D-loop mutations correlated with tumour grade and lymph node metastases, suggesting that analysis of D-loop mutations may have prognostic value [[3]Matsuyama W. Nakagawa M. Wakimoto J. et al.Mitochondrial DNA mutation correlates with stage progression and prognosis in non-small cell lung cancer.Hum Mutat. 2003; 21: 441-443Crossref PubMed Scopus (53) Google Scholar]. We agree that it would be interesting to study large scale deletions and mtDNA copy number changes both as a reflection of oxidative damage and as a cause of production of reactive oxygen species which have been implicated in carcinogenesis. In a prospective study higher mtDNA copy number has been associated with risk of developing lung cancer [[4]Hosgood H.D. Liu C.S. Rothman N. et al.Mitcohondrial DNA copy number and lung cancer risk in a prospective cohort study.Carcinogenesis. 2010; 31: 847-849Crossref PubMed Scopus (140) Google Scholar], however a commonly studied 4977-bp deletion in mtDNA was not demonstrated to be associated with an increased risk of lung cancer [[5]Dai J.G. Xiao Y.B. Min J.X. et al.Mitochondrial DNA 4977 bp deletion mutations in lung carcinoma.Indian J Cancer. 2008; 43: 20-25Google Scholar] despite being higher in bronchoalveolar tissues of smokers [[6]Ballinger S.W. Bouder G. Davis G.S. et al.Mitochondrial genome damage associated with cigarette smoking.Cancer Res. 1996; 56: 5692-5697PubMed Google Scholar]. MtDNA depletions and deletions may also be important in pathogenesis of lung cancerRespiratory MedicineVol. 107Issue 11PreviewWe read the article by Sylvia et al. titled “Mitochondrial DNA mutations in exhaled breath condensate of patients with lung cancer” [1]. In this study, aim of authors is to investigate importance of mutations of mitochondrial DNA (mtDNA) in pathogenesis of lung cancer. The exhaled breath condensate (EBC) and saliva have been analyzed for mitochondrial DNA D loop changes using a PCR sequencing approach. Authors have found significantly elevated D-loop mutation rate in the lung cancer group compared to the control groups. Full-Text PDF Open Archive" @default.
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• W1996453073 date "2013-11-01" @default.
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• W1996453073 title "Response to “MtDNA depletions and deletions may also important in pathogenesis of lung cancer”" @default.
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• W1996453073 doi "https://doi.org/10.1016/j.rmed.2013.08.017" @default.
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