FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996474598> ?p ?o ?g. }

• W1996474598 endingPage "1546" @default.
• W1996474598 startingPage "1530" @default.
• W1996474598 abstract "A computational fluid dynamics (CFD) study examined the impact of particle size on dissolution rate and residence of intravitreal suspension depots of Triamcinolone Acetonide (TAC).A model for the rabbit eye was constructed using insights from high-resolution NMR imaging studies (Sawada 2002). The current model was compared to other published simulations in its ability to predict clearance of various intravitreally injected materials. Suspension depots were constructed explicitly rendering individual particles in various configurations: 4 or 16 mg drug confined to a 100 microL spherical depot, or 4 mg exploded to fill the entire vitreous. Particle size was reduced systematically in each configuration. The convective diffusion/dissolution process was simulated using a multiphase model.Release rate became independent of particle diameter below a certain value. The size-independent limits occurred for particle diameters ranging from 77 to 428 microM depending upon the depot configuration. Residence time predicted for the spherical depots in the size-independent limit was comparable to that observed in vivo.Since the size-independent limit was several-fold greater than the particle size of commercially available pharmaceutical TAC suspensions, differences in particle size amongst such products are predicted to be immaterial to their duration or performance." @default.
• W1996474598 created "2016-06-24" @default.
• W1996474598 creator A5011836743 @default.
• W1996474598 creator A5017203114 @default.
• W1996474598 creator A5083441632 @default.
• W1996474598 date "2010-05-14" @default.
• W1996474598 modified "2023-09-27" @default.
• W1996474598 title "Simulating Dissolution of Intravitreal Triamcinolone Acetonide Suspensions in an Anatomically Accurate Rabbit Eye Model" @default.
• W1996474598 cites W114940910 @default.
• W1996474598 cites W1492861575 @default.
• W1996474598 cites W1964002661 @default.
• W1996474598 cites W1965017337 @default.
• W1996474598 cites W1966576024 @default.
• W1996474598 cites W1968973699 @default.
• W1996474598 cites W1975478673 @default.
• W1996474598 cites W1978770039 @default.
• W1996474598 cites W1980673089 @default.
• W1996474598 cites W1985093075 @default.
• W1996474598 cites W1994787771 @default.
• W1996474598 cites W1995953782 @default.
• W1996474598 cites W1996853317 @default.
• W1996474598 cites W2019075396 @default.
• W1996474598 cites W2029056867 @default.
• W1996474598 cites W2029892497 @default.
• W1996474598 cites W2033304948 @default.
• W1996474598 cites W2040415931 @default.
• W1996474598 cites W2058120142 @default.
• W1996474598 cites W2080952629 @default.
• W1996474598 cites W2084664469 @default.
• W1996474598 cites W2087854144 @default.
• W1996474598 cites W2115277332 @default.
• W1996474598 cites W2134178766 @default.
• W1996474598 cites W2153300540 @default.
• W1996474598 cites W2156466398 @default.
• W1996474598 cites W2159063810 @default.
• W1996474598 cites W2181569653 @default.
• W1996474598 cites W2313533651 @default.
• W1996474598 cites W2506659406 @default.
• W1996474598 cites W4205667368 @default.
• W1996474598 cites W63884891 @default.
• W1996474598 doi "https://doi.org/10.1007/s11095-010-0163-1" @default.
• W1996474598 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2896643" @default.
• W1996474598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20467888" @default.
• W1996474598 hasPublicationYear "2010" @default.
• W1996474598 type Work @default.
• W1996474598 sameAs 1996474598 @default.
• W1996474598 citedByCount "29" @default.
• W1996474598 countsByYear W19964745982012 @default.
• W1996474598 countsByYear W19964745982013 @default.
• W1996474598 countsByYear W19964745982014 @default.
• W1996474598 countsByYear W19964745982015 @default.
• W1996474598 countsByYear W19964745982016 @default.
• W1996474598 countsByYear W19964745982017 @default.
• W1996474598 countsByYear W19964745982018 @default.
• W1996474598 countsByYear W19964745982019 @default.
• W1996474598 countsByYear W19964745982020 @default.
• W1996474598 countsByYear W19964745982021 @default.
• W1996474598 countsByYear W19964745982022 @default.
• W1996474598 countsByYear W19964745982023 @default.
• W1996474598 crossrefType "journal-article" @default.
• W1996474598 hasAuthorship W1996474598A5011836743 @default.
• W1996474598 hasAuthorship W1996474598A5017203114 @default.
• W1996474598 hasAuthorship W1996474598A5083441632 @default.
• W1996474598 hasBestOaLocation W19964745981 @default.
• W1996474598 hasConcept C105341887 @default.
• W1996474598 hasConcept C111368507 @default.
• W1996474598 hasConcept C118487528 @default.
• W1996474598 hasConcept C127313418 @default.
• W1996474598 hasConcept C127413603 @default.
• W1996474598 hasConcept C136229726 @default.
• W1996474598 hasConcept C147789679 @default.
• W1996474598 hasConcept C166957645 @default.
• W1996474598 hasConcept C178790620 @default.
• W1996474598 hasConcept C185592680 @default.
• W1996474598 hasConcept C187320778 @default.
• W1996474598 hasConcept C187530423 @default.
• W1996474598 hasConcept C192562407 @default.
• W1996474598 hasConcept C202444582 @default.
• W1996474598 hasConcept C2775913793 @default.
• W1996474598 hasConcept C2776561332 @default.
• W1996474598 hasConcept C2778517922 @default.
• W1996474598 hasConcept C2778903070 @default.
• W1996474598 hasConcept C33923547 @default.
• W1996474598 hasConcept C43617362 @default.
• W1996474598 hasConcept C5961521 @default.
• W1996474598 hasConcept C71924100 @default.
• W1996474598 hasConcept C88380143 @default.
• W1996474598 hasConcept C95457728 @default.
• W1996474598 hasConceptScore W1996474598C105341887 @default.
• W1996474598 hasConceptScore W1996474598C111368507 @default.
• W1996474598 hasConceptScore W1996474598C118487528 @default.
• W1996474598 hasConceptScore W1996474598C127313418 @default.
• W1996474598 hasConceptScore W1996474598C127413603 @default.
• W1996474598 hasConceptScore W1996474598C136229726 @default.
• W1996474598 hasConceptScore W1996474598C147789679 @default.
• W1996474598 hasConceptScore W1996474598C166957645 @default.
• W1996474598 hasConceptScore W1996474598C178790620 @default.
• W1996474598 hasConceptScore W1996474598C185592680 @default.

• next