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- W1996475191 abstract "Neuropsychological and neuroimaging studies have implicated the dopaminergic nigrostriatal pathway and the prefrontal cortex in learning and memory deficits in patients with Parkinson's disease. However, little is known about how these two brain regions interact in the processing of learning and memory. We employed a disconnection procedure to test whether interaction of these regions contributes to performance in various memory tasks. Male rats received either a unilateral injection of 6-hydroxydopamine into the nigro-striatal tract or a unilateral NMDA lesion in the medial prefrontal cortex, or both these lesions combined in either the same or opposite hemispheres. Spontaneous object exploration, spatial working memory, locomotor, emotional and sensorimotor tests were administered. Only the group with both lesions placed in opposite hemispheres failed to show object recognition memory. None of the groups treated with 6-hydroxydopamine showed intact temporal order memory, whereas only the groups that received combined lesions failed to show object-in-place and spatial recognition memory. No differences between groups were found in the spatial working memory test. Our data indicate that locomotor, emotional and sensorimotor factors are not likely to confound the results of the memory tests. Thus, the interaction between the dopaminergic forebrain projections, particularly the nigrostriatal dopamine, and the medial prefrontal cortex is critical for object recognition memory but not for spatial working memory in rats." @default.
- W1996475191 created "2016-06-24" @default.
- W1996475191 creator A5001938781 @default.
- W1996475191 creator A5016205101 @default.
- W1996475191 creator A5061940282 @default.
- W1996475191 date "2013-09-01" @default.
- W1996475191 modified "2023-10-18" @default.
- W1996475191 title "The interaction between the dopaminergic forebrain projections and the medial prefrontal cortex is critical for memory of objects: Implications for Parkinson's disease" @default.
- W1996475191 cites W1867720884 @default.
- W1996475191 cites W1966132803 @default.
- W1996475191 cites W1966702161 @default.
- W1996475191 cites W1969623416 @default.
- W1996475191 cites W1977313778 @default.
- W1996475191 cites W1978112139 @default.
- W1996475191 cites W1978696443 @default.
- W1996475191 cites W1980944036 @default.
- W1996475191 cites W1981037418 @default.
- W1996475191 cites W1989023409 @default.
- W1996475191 cites W1989297865 @default.
- W1996475191 cites W1989490147 @default.
- W1996475191 cites W1993221373 @default.
- W1996475191 cites W1995033222 @default.
- W1996475191 cites W1996001145 @default.
- W1996475191 cites W1997008008 @default.
- W1996475191 cites W1999897000 @default.
- W1996475191 cites W2003119385 @default.
- W1996475191 cites W2003250265 @default.
- W1996475191 cites W2004876457 @default.
- W1996475191 cites W2005191507 @default.
- W1996475191 cites W2007142995 @default.
- W1996475191 cites W2009021103 @default.
- W1996475191 cites W2010478807 @default.
- W1996475191 cites W2010554387 @default.
- W1996475191 cites W2015011458 @default.
- W1996475191 cites W2022316770 @default.
- W1996475191 cites W2023284963 @default.
- W1996475191 cites W2038636807 @default.
- W1996475191 cites W2038809411 @default.
- W1996475191 cites W2041561931 @default.
- W1996475191 cites W2048490376 @default.
- W1996475191 cites W2049184686 @default.
- W1996475191 cites W2049191904 @default.
- W1996475191 cites W2051994215 @default.
- W1996475191 cites W2059215368 @default.
- W1996475191 cites W2059351781 @default.
- W1996475191 cites W2061068505 @default.
- W1996475191 cites W2063582503 @default.
- W1996475191 cites W2064481951 @default.
- W1996475191 cites W2069559360 @default.
- W1996475191 cites W2070365656 @default.
- W1996475191 cites W2072441360 @default.
- W1996475191 cites W2074234271 @default.
- W1996475191 cites W2078443407 @default.
- W1996475191 cites W2080831364 @default.
- W1996475191 cites W2081102141 @default.
- W1996475191 cites W2081681461 @default.
- W1996475191 cites W2081968259 @default.
- W1996475191 cites W2085519455 @default.
- W1996475191 cites W2086241581 @default.
- W1996475191 cites W2086614351 @default.
- W1996475191 cites W2089291555 @default.
- W1996475191 cites W2089310711 @default.
- W1996475191 cites W2091649450 @default.
- W1996475191 cites W2092843094 @default.
- W1996475191 cites W2093865682 @default.
- W1996475191 cites W2095056606 @default.
- W1996475191 cites W2099652807 @default.
- W1996475191 cites W2107253984 @default.
- W1996475191 cites W2107273549 @default.
- W1996475191 cites W2108310775 @default.
- W1996475191 cites W2111408945 @default.
- W1996475191 cites W2112648950 @default.
- W1996475191 cites W2112823441 @default.
- W1996475191 cites W2114302768 @default.
- W1996475191 cites W2116958494 @default.
- W1996475191 cites W2120819100 @default.
- W1996475191 cites W2128443648 @default.
- W1996475191 cites W2128928835 @default.
- W1996475191 cites W2138951864 @default.
- W1996475191 cites W2142455573 @default.
- W1996475191 cites W2144531560 @default.
- W1996475191 cites W2145490055 @default.
- W1996475191 cites W2147659195 @default.
- W1996475191 cites W2149885167 @default.
- W1996475191 cites W2151248906 @default.
- W1996475191 cites W2152316935 @default.
- W1996475191 cites W2158944877 @default.
- W1996475191 cites W2159146218 @default.
- W1996475191 cites W2170824306 @default.
- W1996475191 cites W2346578572 @default.
- W1996475191 cites W37005 @default.
- W1996475191 cites W4247261289 @default.
- W1996475191 cites W4251956774 @default.
- W1996475191 cites W49996880 @default.
- W1996475191 cites W62603772 @default.
- W1996475191 doi "https://doi.org/10.1016/j.expneurol.2013.01.003" @default.
- W1996475191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23313193" @default.
- W1996475191 hasPublicationYear "2013" @default.