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• W1996476215 abstract "Sequence specificity in the binding of the actinomycins to DNA has been studied by measuring the dissociation constants of several deoxyribodinucleotide-actinomycin complexes by spectral-titration. Additional data for some mononucleotides and for a deoxyribotetranucleotide have been collected for comparison. The results show that: G-Containing dinucleotides form complexes of roughly 10 times higher stability than G-free dinucleotides. These data parallel the corresponding results for mononucleotides [16]. The G-containing dinucleotides may be subdivided into three classes of the following sequential types: a) d(pX-G), which bind the actinomycins with similar affinity as the dGMP, b) d(pG-X), which bind the actinomycins less strongly than dGMP, and c) d(pG-C), which binds the actinomycins in a 2:1 complex (two dinucleotides per dye molecule) of higher stability than all the other dinucleotides. The tetranucleotide d(pC-T-A-G) behaves as the dinucleotides of type a. Molecular weights of the complexes as determined by sedimentation equilibrium measurements confirmed the stoichiometry of the actinomycin-d(pG-C) complex obtained by titration. Corresponding measurements for the actinomycin complexes of d(pC-G) and d(pC-T-A-G) revealed that the antibiotic strongly favours double helix formation of these self complementary oligonucleotides, yielding 2:2 complexes with two equivalent binding sites at the ends of the helices. All data are consistent with fixation of the actinomycin chromophore on the 3′-side of the dG-residue as in the actinomycin-dG crystal [8]." @default.
• W1996476215 created "2016-06-24" @default.
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• W1996476215 date "1972-09-01" @default.
• W1996476215 modified "2023-09-25" @default.
• W1996476215 title "Uber die Wechselwirkung des Actinomycin C3 mit Mono-, Di- und Oligonucleotiden" @default.
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• W1996476215 doi "https://doi.org/10.1111/j.1432-1033.1972.tb01977.x" @default.
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