Matches in SemOpenAlex for { <https://semopenalex.org/work/W199648720> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W199648720 abstract "Tuberculosis kills nearly 2 million people each year, and more than one-third of the worldi?½s population is infected with the causative agent, Mycobacterium tuberculosis. Mycobacteriophages, or bacteriophages that infect Mycobacterium species including M. tuberculosis, are already being used as tools to study mycobacteria and diagnose tuberculosis. More than 60 mycobacteriophage genomes have been sequenced, revealing a vast genetic reservoir containing elements useful to the study and manipulation of mycobacteria. Mycobacteriophages also encode proteins capable of fast and efficient killing of the host cell. In most bacteriophages, lysis of the host cell to release progeny phage requires at minimum two proteins: a holin that mediates the timing of lysis and permeabilizes the cell membrane, and an endolysin (lysin) that degrades peptidoglycan. Accessory lysis proteins have also been discovered, often with functions specific to that phagei?½s host.Many lysins of phages infecting Gram-positive bacteria are proving to be potent antibacterials. Further, lysis proteins can provide insight into the properties and composition of the host cell wall. Given the complexity of the mycobacterial cell wall and its medical relevance in tuberculosis as an immunogenic barrier that complicates treatment, as well as the urgent need for new therapeutic options, the mycobacteriophage lysins clearly warrant further scientific investigation.This work focuses on the mycobacteriophage lysin LysA and the accessory lysis protein LysB. Bioinformatic characterizations show that LysA proteins posess a variety of domains arranged in modular organizations, reflecting extensive recombination within the mycobacteriophage population. In addition to known peptidoglycan-hydrolytic activities, novel cell wall-binding domains are identified, as well as several domains of unknown function found only in mycobacteriophages. LysB proteins are unique to mycobacteriophages and perform a singular role as mycolylarabinogalactan esterases that sever the connection between the mycobacterial outer membrane and the peptidoglycan cell wall complex to ensure efficient lysis and progeny phage release. There is also preliminary evidence of peptidoglycan hydrolytic ability, inducible cell lysis, and growth inhibition of Mycobacterium smegmatis by LysA and LysB proteins. These studies suggest that mycobacteriophage lysis proteins can be exploited as useful tools, both in the laboratory and clinical setting." @default.
- W199648720 created "2016-06-24" @default.
- W199648720 creator A5063625853 @default.
- W199648720 date "2011-02-25" @default.
- W199648720 modified "2023-09-27" @default.
- W199648720 title "MYCOBACTERIOPHAGE LYSINS: BIOINFORMATIC CHARACTERIZATION OF LYSIN A AND IDENTIFICATION OF THE FUNCTION OF LYSIN B IN INFECTION" @default.
- W199648720 hasPublicationYear "2011" @default.
- W199648720 type Work @default.
- W199648720 sameAs 199648720 @default.
- W199648720 citedByCount "2" @default.
- W199648720 countsByYear W1996487202014 @default.
- W199648720 countsByYear W1996487202017 @default.
- W199648720 crossrefType "journal-article" @default.
- W199648720 hasAuthorship W199648720A5063625853 @default.
- W199648720 hasConcept C104317684 @default.
- W199648720 hasConcept C125235067 @default.
- W199648720 hasConcept C142724271 @default.
- W199648720 hasConcept C22538091 @default.
- W199648720 hasConcept C2776441376 @default.
- W199648720 hasConcept C2776634448 @default.
- W199648720 hasConcept C2777975735 @default.
- W199648720 hasConcept C2780374374 @default.
- W199648720 hasConcept C2781069245 @default.
- W199648720 hasConcept C2908647359 @default.
- W199648720 hasConcept C523546767 @default.
- W199648720 hasConcept C54355233 @default.
- W199648720 hasConcept C547475151 @default.
- W199648720 hasConcept C55493867 @default.
- W199648720 hasConcept C57409179 @default.
- W199648720 hasConcept C71924100 @default.
- W199648720 hasConcept C86803240 @default.
- W199648720 hasConcept C89423630 @default.
- W199648720 hasConcept C99454951 @default.
- W199648720 hasConceptScore W199648720C104317684 @default.
- W199648720 hasConceptScore W199648720C125235067 @default.
- W199648720 hasConceptScore W199648720C142724271 @default.
- W199648720 hasConceptScore W199648720C22538091 @default.
- W199648720 hasConceptScore W199648720C2776441376 @default.
- W199648720 hasConceptScore W199648720C2776634448 @default.
- W199648720 hasConceptScore W199648720C2777975735 @default.
- W199648720 hasConceptScore W199648720C2780374374 @default.
- W199648720 hasConceptScore W199648720C2781069245 @default.
- W199648720 hasConceptScore W199648720C2908647359 @default.
- W199648720 hasConceptScore W199648720C523546767 @default.
- W199648720 hasConceptScore W199648720C54355233 @default.
- W199648720 hasConceptScore W199648720C547475151 @default.
- W199648720 hasConceptScore W199648720C55493867 @default.
- W199648720 hasConceptScore W199648720C57409179 @default.
- W199648720 hasConceptScore W199648720C71924100 @default.
- W199648720 hasConceptScore W199648720C86803240 @default.
- W199648720 hasConceptScore W199648720C89423630 @default.
- W199648720 hasConceptScore W199648720C99454951 @default.
- W199648720 hasLocation W1996487201 @default.
- W199648720 hasOpenAccess W199648720 @default.
- W199648720 hasPrimaryLocation W1996487201 @default.
- W199648720 hasRelatedWork W1890692049 @default.
- W199648720 hasRelatedWork W1980590015 @default.
- W199648720 hasRelatedWork W2003200347 @default.
- W199648720 hasRelatedWork W2014783118 @default.
- W199648720 hasRelatedWork W2042805950 @default.
- W199648720 hasRelatedWork W2045300887 @default.
- W199648720 hasRelatedWork W2154984047 @default.
- W199648720 hasRelatedWork W2342112924 @default.
- W199648720 hasRelatedWork W2360452413 @default.
- W199648720 hasRelatedWork W2598701129 @default.
- W199648720 hasRelatedWork W2886578840 @default.
- W199648720 hasRelatedWork W2941759542 @default.
- W199648720 hasRelatedWork W2943882030 @default.
- W199648720 hasRelatedWork W2985872088 @default.
- W199648720 hasRelatedWork W3010962668 @default.
- W199648720 hasRelatedWork W3049674277 @default.
- W199648720 hasRelatedWork W3156313268 @default.
- W199648720 hasRelatedWork W3165677986 @default.
- W199648720 hasRelatedWork W974546713 @default.
- W199648720 hasRelatedWork W3090316673 @default.
- W199648720 isParatext "false" @default.
- W199648720 isRetracted "false" @default.
- W199648720 magId "199648720" @default.
- W199648720 workType "article" @default.