Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996490483> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1996490483 abstract "The effect of three adjuvants - alum, N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP), and liposomes - on the IgG antibody isotype response to bovine serum albumin (BSA), was determined in normal and LP-BM5 retrovirus infected C57BL/6 mice. Alum and MDP induced comparable levels of IgG antibodies in normal mice (predominantly IgG1 (greater than 90%)), whereas liposomes induced IgG1 (60%), IgG2a/b (30%) and IgG3 (10%) antibodies. IgG antibody levels using liposomes as adjuvant were five-fold higher than those observed with alum or MDP. Immunization after LP-BM5 infection significantly reduced the effectiveness of alum and MDP, IgG antibody levels being reduced by 80 and 90% at 3 or 7 weeks respectively. The adjuvant activity of liposomes was reduced by 55 and 65% when immunization was started 3 or 7 weeks post LP-BM5 infection. Boosting of pre-immune mice with BSA and alum, MDP or liposomes 3 weeks after LP-BM5 infection showed that, while the magnitude of the antibody response and isotype distribution was not affected, the persistence of the response was severely diminished compared to control, non-infected mice. The reduced immunoadjuvant activity correlated with a reduction in the frequency of splenic Thy1.2+/CD4+ T cells. These results demonstrated that liposomes were more effective than alum or MDP in inducing IgG antibodies, and that immunoadjuvant activity for prophylactic or therapeutic immunization for all 3 adjuvants was significantly impaired by retroviral infections." @default.
- W1996490483 created "2016-06-24" @default.
- W1996490483 creator A5071529723 @default.
- W1996490483 date "1992-04-01" @default.
- W1996490483 modified "2023-09-26" @default.
- W1996490483 title "Impaired stimulation of anti-bovine serum albumin IgG antibodies by vaccine adjuvants in murine acquired immunodeficiency syndrome" @default.
- W1996490483 cites W1964520361 @default.
- W1996490483 cites W1973795001 @default.
- W1996490483 cites W1978406852 @default.
- W1996490483 cites W1981973005 @default.
- W1996490483 cites W1984953616 @default.
- W1996490483 cites W1989894465 @default.
- W1996490483 cites W1999881560 @default.
- W1996490483 cites W2000992025 @default.
- W1996490483 cites W2001046450 @default.
- W1996490483 cites W2003531942 @default.
- W1996490483 cites W2006239087 @default.
- W1996490483 cites W2009576478 @default.
- W1996490483 cites W2012316443 @default.
- W1996490483 cites W2018019782 @default.
- W1996490483 cites W2024092184 @default.
- W1996490483 cites W2032756112 @default.
- W1996490483 cites W2033962378 @default.
- W1996490483 cites W2039800467 @default.
- W1996490483 cites W2047526826 @default.
- W1996490483 cites W2050889004 @default.
- W1996490483 cites W2059244693 @default.
- W1996490483 cites W2068431093 @default.
- W1996490483 cites W2069009509 @default.
- W1996490483 cites W2085540367 @default.
- W1996490483 cites W2087774304 @default.
- W1996490483 cites W2094703720 @default.
- W1996490483 cites W2109044345 @default.
- W1996490483 cites W2115853040 @default.
- W1996490483 cites W2116372466 @default.
- W1996490483 cites W2118588327 @default.
- W1996490483 cites W2127508135 @default.
- W1996490483 cites W2167706899 @default.
- W1996490483 cites W2226409518 @default.
- W1996490483 cites W2326297818 @default.
- W1996490483 cites W2468423585 @default.
- W1996490483 cites W4298876692 @default.
- W1996490483 cites W4299546478 @default.
- W1996490483 doi "https://doi.org/10.1111/j.1574-6968.1992.tb04996.x" @default.
- W1996490483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1599706" @default.
- W1996490483 hasPublicationYear "1992" @default.
- W1996490483 type Work @default.
- W1996490483 sameAs 1996490483 @default.
- W1996490483 citedByCount "5" @default.
- W1996490483 crossrefType "journal-article" @default.
- W1996490483 hasAuthorship W1996490483A5071529723 @default.
- W1996490483 hasBestOaLocation W19964904831 @default.
- W1996490483 hasConcept C159654299 @default.
- W1996490483 hasConcept C178790620 @default.
- W1996490483 hasConcept C185592680 @default.
- W1996490483 hasConcept C203014093 @default.
- W1996490483 hasConcept C2776946954 @default.
- W1996490483 hasConcept C2777863537 @default.
- W1996490483 hasConcept C2777991845 @default.
- W1996490483 hasConcept C2780801004 @default.
- W1996490483 hasConcept C2780898057 @default.
- W1996490483 hasConcept C2780924562 @default.
- W1996490483 hasConcept C2909935589 @default.
- W1996490483 hasConcept C542903549 @default.
- W1996490483 hasConcept C86803240 @default.
- W1996490483 hasConcept C86807702 @default.
- W1996490483 hasConcept C8891405 @default.
- W1996490483 hasConceptScore W1996490483C159654299 @default.
- W1996490483 hasConceptScore W1996490483C178790620 @default.
- W1996490483 hasConceptScore W1996490483C185592680 @default.
- W1996490483 hasConceptScore W1996490483C203014093 @default.
- W1996490483 hasConceptScore W1996490483C2776946954 @default.
- W1996490483 hasConceptScore W1996490483C2777863537 @default.
- W1996490483 hasConceptScore W1996490483C2777991845 @default.
- W1996490483 hasConceptScore W1996490483C2780801004 @default.
- W1996490483 hasConceptScore W1996490483C2780898057 @default.
- W1996490483 hasConceptScore W1996490483C2780924562 @default.
- W1996490483 hasConceptScore W1996490483C2909935589 @default.
- W1996490483 hasConceptScore W1996490483C542903549 @default.
- W1996490483 hasConceptScore W1996490483C86803240 @default.
- W1996490483 hasConceptScore W1996490483C86807702 @default.
- W1996490483 hasConceptScore W1996490483C8891405 @default.
- W1996490483 hasLocation W19964904831 @default.
- W1996490483 hasLocation W19964904832 @default.
- W1996490483 hasOpenAccess W1996490483 @default.
- W1996490483 hasPrimaryLocation W19964904831 @default.
- W1996490483 hasRelatedWork W1996490483 @default.
- W1996490483 hasRelatedWork W1997025461 @default.
- W1996490483 hasRelatedWork W2009576478 @default.
- W1996490483 hasRelatedWork W2027916689 @default.
- W1996490483 hasRelatedWork W2030731947 @default.
- W1996490483 hasRelatedWork W2035672111 @default.
- W1996490483 hasRelatedWork W2099244599 @default.
- W1996490483 hasRelatedWork W2736540239 @default.
- W1996490483 hasRelatedWork W2741138112 @default.
- W1996490483 hasRelatedWork W2772568294 @default.
- W1996490483 isParatext "false" @default.
- W1996490483 isRetracted "false" @default.
- W1996490483 magId "1996490483" @default.
- W1996490483 workType "article" @default.