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- W1996496268 abstract "Potentiometric sensors based on dinonylnaphthalene sulfonic acid (DNNS) were prepared for several recently developed drugs used in the treatment of cardiovascular disorders. Thus, incorporation of DNNS along with the β-adrenergic blocker Acebutalol, or calcium-channel blockers Verapamil, Diltiazem, Nicardipine, or Lidoflazine into a plasticized poly(vinyl chloride) membrane resulted in coated-wire ion-selective electrodes which displayed nearly Nernstian response in the concentration range 10−3–10−5 M and quantitatively useful responses down to 10−6 M. Selectivity behavior for each set of electrodes was accurately predicted from calculated distribution constants for the respective drugs. Application of these electrodes to pharmaceutical preparations is discussed, as is their utility in pharmacokinetic studies." @default.
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- W1996496268 date "1984-01-01" @default.
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- W1996496268 title "On-selective electrodes for some β-adrenergic and calcium blockers" @default.
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- W1996496268 doi "https://doi.org/10.1016/s0003-2670(00)83616-8" @default.
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