FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996498008> ?p ?o ?g. }

• W1996498008 endingPage "1835" @default.
• W1996498008 startingPage "1831" @default.
• W1996498008 abstract "BACKGROUND More than 50% of breast ductal carcinomas in situ (DCIS) contain significant histologic necrosis, an important prognostic factor for determining recurrence and progression to invasive breast cancer. We have examined whether the mechanism of this spontaneous cell death might be apoptosis, a genetically encoded suicide pathway that may be triggered by various events including dysregulated cell proliferation. METHODS Twenty-five untreated DCIS cases accessioned at our institution were examined for subtype, grade, and presence of apoptosis using two criteria: (1) cellular morphology (shrinkage, nuclear condensation, fragmentation, apoptotic bodies, and lack of inflammatory component); and (2) terminal transferase (TUNEL) staining of DNA fragmentation, a characteristic though less specific feature of apoptosis. Immunohistochemical staining was also carried out to assess whether wild-type p53, a regulator of apoptosis, was associated with this cell death. RESULTS In all 19 cases with intraductal necrosis, cellular morphology was consistent with apoptotic death, despite its presence within sheets of “geographic necrosis.” Additionally, the identical regions were all strongly TUNEL-positive. No evidence of TUNEL staining was seen in 5 Grade I DCIS cases without intraductal necrosis. Immunohistochemical staining suggested that this apoptosis was independent of p53 mutational status. CONCLUSIONS Extensive intraductal necrosis in DCIS is likely to represent apoptosis. However, it is unlikely that this apoptosis is regulated by p53. The apparently abundant apoptosis identified here, particularly in high grade DCIS, may be important in explaining why spontaneous cell death in DCIS is associated with a worse prognosis. Cancer 1996;77:1831-5." @default.
• W1996498008 created "2016-06-24" @default.
• W1996498008 creator A5007365512 @default.
• W1996498008 creator A5009887943 @default.
• W1996498008 creator A5023484082 @default.
• W1996498008 creator A5078561959 @default.
• W1996498008 creator A5078874539 @default.
• W1996498008 date "1996-05-01" @default.
• W1996498008 modified "2023-10-12" @default.
• W1996498008 title "Extensive apoptosis in ductal carcinoma in situ of the breast" @default.
• W1996498008 cites W1979319210 @default.
• W1996498008 cites W1989963027 @default.
• W1996498008 cites W2010875574 @default.
• W1996498008 cites W2013330927 @default.
• W1996498008 cites W2021326683 @default.
• W1996498008 cites W2025369435 @default.
• W1996498008 cites W2036547499 @default.
• W1996498008 cites W2042040568 @default.
• W1996498008 cites W2042696772 @default.
• W1996498008 cites W2046883067 @default.
• W1996498008 cites W2052853635 @default.
• W1996498008 cites W2055926056 @default.
• W1996498008 cites W2068889468 @default.
• W1996498008 cites W2072110559 @default.
• W1996498008 cites W2078003307 @default.
• W1996498008 cites W2081110323 @default.
• W1996498008 cites W2081894694 @default.
• W1996498008 cites W2081948388 @default.
• W1996498008 cites W2114698200 @default.
• W1996498008 cites W2138302361 @default.
• W1996498008 cites W2318327263 @default.
• W1996498008 cites W267182146 @default.
• W1996498008 cites W3188489634 @default.
• W1996498008 cites W4229662680 @default.
• W1996498008 cites W4235743521 @default.
• W1996498008 cites W4247453351 @default.
• W1996498008 doi "https://doi.org/10.1002/(sici)1097-0142(19960501)77:9<1831::aid-cncr11>3.0.co;2-0" @default.
• W1996498008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8646681" @default.
• W1996498008 hasPublicationYear "1996" @default.
• W1996498008 type Work @default.
• W1996498008 sameAs 1996498008 @default.
• W1996498008 citedByCount "56" @default.
• W1996498008 countsByYear W19964980082012 @default.
• W1996498008 countsByYear W19964980082013 @default.
• W1996498008 countsByYear W19964980082018 @default.
• W1996498008 crossrefType "journal-article" @default.
• W1996498008 hasAuthorship W1996498008A5007365512 @default.
• W1996498008 hasAuthorship W1996498008A5009887943 @default.
• W1996498008 hasAuthorship W1996498008A5023484082 @default.
• W1996498008 hasAuthorship W1996498008A5078561959 @default.
• W1996498008 hasAuthorship W1996498008A5078874539 @default.
• W1996498008 hasBestOaLocation W19964980081 @default.
• W1996498008 hasConcept C121608353 @default.
• W1996498008 hasConcept C126322002 @default.
• W1996498008 hasConcept C142724271 @default.
• W1996498008 hasConcept C18903297 @default.
• W1996498008 hasConcept C190283241 @default.
• W1996498008 hasConcept C191015642 @default.
• W1996498008 hasConcept C196795494 @default.
• W1996498008 hasConcept C204232928 @default.
• W1996498008 hasConcept C2777546739 @default.
• W1996498008 hasConcept C2777661416 @default.
• W1996498008 hasConcept C2780862961 @default.
• W1996498008 hasConcept C31573885 @default.
• W1996498008 hasConcept C43759708 @default.
• W1996498008 hasConcept C502942594 @default.
• W1996498008 hasConcept C503630168 @default.
• W1996498008 hasConcept C530470458 @default.
• W1996498008 hasConcept C55493867 @default.
• W1996498008 hasConcept C71924100 @default.
• W1996498008 hasConcept C86803240 @default.
• W1996498008 hasConceptScore W1996498008C121608353 @default.
• W1996498008 hasConceptScore W1996498008C126322002 @default.
• W1996498008 hasConceptScore W1996498008C142724271 @default.
• W1996498008 hasConceptScore W1996498008C18903297 @default.
• W1996498008 hasConceptScore W1996498008C190283241 @default.
• W1996498008 hasConceptScore W1996498008C191015642 @default.
• W1996498008 hasConceptScore W1996498008C196795494 @default.
• W1996498008 hasConceptScore W1996498008C204232928 @default.
• W1996498008 hasConceptScore W1996498008C2777546739 @default.
• W1996498008 hasConceptScore W1996498008C2777661416 @default.
• W1996498008 hasConceptScore W1996498008C2780862961 @default.
• W1996498008 hasConceptScore W1996498008C31573885 @default.
• W1996498008 hasConceptScore W1996498008C43759708 @default.
• W1996498008 hasConceptScore W1996498008C502942594 @default.
• W1996498008 hasConceptScore W1996498008C503630168 @default.
• W1996498008 hasConceptScore W1996498008C530470458 @default.
• W1996498008 hasConceptScore W1996498008C55493867 @default.
• W1996498008 hasConceptScore W1996498008C71924100 @default.
• W1996498008 hasConceptScore W1996498008C86803240 @default.
• W1996498008 hasIssue "9" @default.
• W1996498008 hasLocation W19964980081 @default.
• W1996498008 hasLocation W19964980082 @default.
• W1996498008 hasOpenAccess W1996498008 @default.
• W1996498008 hasPrimaryLocation W19964980081 @default.
• W1996498008 hasRelatedWork W1986527765 @default.
• W1996498008 hasRelatedWork W1997319347 @default.
• W1996498008 hasRelatedWork W2053020665 @default.

• next