FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996513961> ?p ?o ?g. }

• W1996513961 endingPage "14759" @default.
• W1996513961 startingPage "14744" @default.
• W1996513961 abstract "Enzymatically oxygenated derivatives of the omega-3 fatty acids cis-4,7,10,13,16,19-docosahexaenoic acid (DHA) and cis-5,8,11,14,17-eicosapentaenoic acid, known as resolvins, have potent inflammation resolution activity (Serhan, C. N., Clish, C. B., Brannon, J., Colgan, S. P., Chiang, N., and Gronert, K. (2000) J. Exp. Med. 192, 1197-1204; Hong, S., Gronert, K., Devchand, P. R., Moussignac, R., and Serhan, C. N. (2003) J. Biol. Chem. 278, 14677-14687). Our objective was to determine whether similar derivatives are enzymatically synthesized from other C-22 fatty acids and whether these molecules possess inflammation resolution properties. The reaction of DHA, DPAn-3, and DPAn-6 with 5-, 12-, and 15-lipoxygenases produced oxylipins, which were identified and characterized by liquid chromatography coupled with tandem mass-spectrometry. DPAn-6 and DPAn-3 proved to be good substrates for 15-lipoxygenase. 15-Lipoxygenase proved to be the most efficient enzyme of the three tested for conversion of long chain polyunsaturated fatty acids to corresponding oxylipins. Since DPAn-6 is a major component of Martek DHA-S oil, we focused our attention on reaction products obtained from the DPAn-6 and 15-lipoxygenase reaction. (17S)-hydroxy-DPAn-6 and (10,17S)-dihydroxy-DPAn-6 were the main products of this reaction. These compounds were purified by preparatory high performance liquid chromatography techniques and further characterized by NMR, UV spectrophotometry, and tandem mass spectrometry. We tested both compounds in two animal models of acute inflammation and demonstrated that both compounds are potent anti-inflammatory agents that are active on local intravenous as well as oral administration. These oxygenated DPAn-6 compounds can thus be categorized as a new class of DPAn-6-derived resolvins." @default.
• W1996513961 created "2016-06-24" @default.
• W1996513961 creator A5010090905 @default.
• W1996513961 creator A5025259683 @default.
• W1996513961 creator A5026975830 @default.
• W1996513961 creator A5039932747 @default.
• W1996513961 creator A5070051820 @default.
• W1996513961 creator A5071460094 @default.
• W1996513961 creator A5073101546 @default.
• W1996513961 date "2009-05-01" @default.
• W1996513961 modified "2023-10-14" @default.
• W1996513961 title "Biogenic Synthesis, Purification, and Chemical Characterization of Anti-inflammatory Resolvins Derived from Docosapentaenoic Acid (DPAn-6)" @default.
• W1996513961 cites W1421289767 @default.
• W1996513961 cites W1488735754 @default.
• W1996513961 cites W1531198291 @default.
• W1996513961 cites W1587189409 @default.
• W1996513961 cites W1739691545 @default.
• W1996513961 cites W1812391321 @default.
• W1996513961 cites W1959056525 @default.
• W1996513961 cites W1973759270 @default.
• W1996513961 cites W1975531685 @default.
• W1996513961 cites W1979004719 @default.
• W1996513961 cites W1981592867 @default.
• W1996513961 cites W1981819970 @default.
• W1996513961 cites W1985517047 @default.
• W1996513961 cites W1988319608 @default.
• W1996513961 cites W1988944336 @default.
• W1996513961 cites W1989856248 @default.
• W1996513961 cites W1993670933 @default.
• W1996513961 cites W1999869429 @default.
• W1996513961 cites W2003194224 @default.
• W1996513961 cites W2006888325 @default.
• W1996513961 cites W2014208353 @default.
• W1996513961 cites W2024176341 @default.
• W1996513961 cites W2045777008 @default.
• W1996513961 cites W2048661776 @default.
• W1996513961 cites W205238248 @default.
• W1996513961 cites W2059290956 @default.
• W1996513961 cites W2059959435 @default.
• W1996513961 cites W2064320740 @default.
• W1996513961 cites W2064374001 @default.
• W1996513961 cites W2068167523 @default.
• W1996513961 cites W2069450664 @default.
• W1996513961 cites W2069506489 @default.
• W1996513961 cites W2070620348 @default.
• W1996513961 cites W2070740222 @default.
• W1996513961 cites W2081200207 @default.
• W1996513961 cites W2082649626 @default.
• W1996513961 cites W2083447348 @default.
• W1996513961 cites W2096576358 @default.
• W1996513961 cites W2100726346 @default.
• W1996513961 cites W2102138771 @default.
• W1996513961 cites W2104285446 @default.
• W1996513961 cites W2109225320 @default.
• W1996513961 cites W2112573210 @default.
• W1996513961 cites W2116037211 @default.
• W1996513961 cites W2118149691 @default.
• W1996513961 cites W2121949424 @default.
• W1996513961 cites W2123022291 @default.
• W1996513961 cites W2131904909 @default.
• W1996513961 cites W2135732933 @default.
• W1996513961 cites W2141881913 @default.
• W1996513961 cites W2144137477 @default.
• W1996513961 cites W2152145035 @default.
• W1996513961 cites W2154205448 @default.
• W1996513961 cites W2154358871 @default.
• W1996513961 cites W2162465757 @default.
• W1996513961 cites W2165433466 @default.
• W1996513961 cites W233070627 @default.
• W1996513961 cites W2406774866 @default.
• W1996513961 doi "https://doi.org/10.1074/jbc.m809014200" @default.
• W1996513961 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2685656" @default.
• W1996513961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19324874" @default.
• W1996513961 hasPublicationYear "2009" @default.
• W1996513961 type Work @default.
• W1996513961 sameAs 1996513961 @default.
• W1996513961 citedByCount "63" @default.
• W1996513961 countsByYear W19965139612012 @default.
• W1996513961 countsByYear W19965139612013 @default.
• W1996513961 countsByYear W19965139612014 @default.
• W1996513961 countsByYear W19965139612015 @default.
• W1996513961 countsByYear W19965139612016 @default.
• W1996513961 countsByYear W19965139612017 @default.
• W1996513961 countsByYear W19965139612018 @default.
• W1996513961 countsByYear W19965139612019 @default.
• W1996513961 countsByYear W19965139612020 @default.
• W1996513961 countsByYear W19965139612021 @default.
• W1996513961 countsByYear W19965139612022 @default.
• W1996513961 crossrefType "journal-article" @default.
• W1996513961 hasAuthorship W1996513961A5010090905 @default.
• W1996513961 hasAuthorship W1996513961A5025259683 @default.
• W1996513961 hasAuthorship W1996513961A5026975830 @default.
• W1996513961 hasAuthorship W1996513961A5039932747 @default.
• W1996513961 hasAuthorship W1996513961A5070051820 @default.
• W1996513961 hasAuthorship W1996513961A5071460094 @default.
• W1996513961 hasAuthorship W1996513961A5073101546 @default.
• W1996513961 hasBestOaLocation W19965139611 @default.
• W1996513961 hasConcept C162356407 @default.

• next