Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996515510> ?p ?o ?g. }
- W1996515510 endingPage "53" @default.
- W1996515510 startingPage "41" @default.
- W1996515510 abstract "Toxic Zn(2+) influx may be a key mechanism underlying selective neuronal death after transient global ischemia in rats. To identify routes responsible for neuronal Zn(2+) influx, we measured the accumulation of (65)Zn(2+) into cultured murine cortical cells under depolarizing conditions (60 mM K(+)) associated with severe hypoxia-ischemia in brain tissue. Addition of 60 mM K(+) or 300 microM kainate substantially increased (65)Zn(2+) accumulation into mixed cultures of neurons and glia, but not glia alone. (65)Zn(2+) accumulation was attenuated by increasing concentrations of extracellular Ca(2+) or trypsin pretreatment, but not by late trypsinization, and corresponded to an increase in atomic Zn(2+). Confirming predominantly neuronal entry, K(+)-induced (65)Zn(2+) accumulation was reduced by prior selective destruction of neurons with NMDA. K(+)-induced (65)Zn(2+) influx was not sensitive to glutamate receptor antagonists, but was attenuated by Gd(3+) and Cd(2+) as well as 1 microM nimodipine; it was partially sensitive to 1 microM omega-conotoxin-GVIA, and insensitive to 1 microM omega-agatoxin-IVA. K(+)-induced, Gd(3+)-sensitive (45)Ca(2+) accumulation but not (65)Zn(2+) accumulation was sharply attenuated by lowering extracellular pH to 6.6." @default.
- W1996515510 created "2016-06-24" @default.
- W1996515510 creator A5036363062 @default.
- W1996515510 creator A5040610824 @default.
- W1996515510 creator A5051403739 @default.
- W1996515510 creator A5066110360 @default.
- W1996515510 creator A5068794661 @default.
- W1996515510 date "2002-06-01" @default.
- W1996515510 modified "2023-09-23" @default.
- W1996515510 title "Depolarization-Induced 65Zinc Influx into Cultured Cortical Neurons" @default.
- W1996515510 cites W10673897 @default.
- W1996515510 cites W1488629111 @default.
- W1996515510 cites W1510274000 @default.
- W1996515510 cites W1523671473 @default.
- W1996515510 cites W157666778 @default.
- W1996515510 cites W1586318373 @default.
- W1996515510 cites W1797134060 @default.
- W1996515510 cites W1967301498 @default.
- W1996515510 cites W1977938288 @default.
- W1996515510 cites W1979856671 @default.
- W1996515510 cites W1981959240 @default.
- W1996515510 cites W1982569456 @default.
- W1996515510 cites W1983137704 @default.
- W1996515510 cites W1990557260 @default.
- W1996515510 cites W1991647860 @default.
- W1996515510 cites W1996236659 @default.
- W1996515510 cites W2000365406 @default.
- W1996515510 cites W2000587840 @default.
- W1996515510 cites W2004007082 @default.
- W1996515510 cites W2009881580 @default.
- W1996515510 cites W2013986174 @default.
- W1996515510 cites W2014074624 @default.
- W1996515510 cites W2016979211 @default.
- W1996515510 cites W2018883950 @default.
- W1996515510 cites W2025392991 @default.
- W1996515510 cites W2029080264 @default.
- W1996515510 cites W2030034009 @default.
- W1996515510 cites W2033558463 @default.
- W1996515510 cites W2035594105 @default.
- W1996515510 cites W2038367010 @default.
- W1996515510 cites W2041360032 @default.
- W1996515510 cites W2044981704 @default.
- W1996515510 cites W2054566340 @default.
- W1996515510 cites W2054858587 @default.
- W1996515510 cites W2060086459 @default.
- W1996515510 cites W2071213192 @default.
- W1996515510 cites W2072476822 @default.
- W1996515510 cites W2078447569 @default.
- W1996515510 cites W2082469108 @default.
- W1996515510 cites W2084165595 @default.
- W1996515510 cites W2093477633 @default.
- W1996515510 cites W2093840338 @default.
- W1996515510 cites W2099973943 @default.
- W1996515510 cites W2103816576 @default.
- W1996515510 cites W2133819402 @default.
- W1996515510 cites W2134716820 @default.
- W1996515510 cites W2137530842 @default.
- W1996515510 cites W2138149556 @default.
- W1996515510 cites W2144759791 @default.
- W1996515510 cites W2170520883 @default.
- W1996515510 cites W2171446064 @default.
- W1996515510 cites W2242791010 @default.
- W1996515510 cites W2413570053 @default.
- W1996515510 cites W2419382506 @default.
- W1996515510 cites W2885879479 @default.
- W1996515510 doi "https://doi.org/10.1006/nbdi.2002.0497" @default.
- W1996515510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12079403" @default.
- W1996515510 hasPublicationYear "2002" @default.
- W1996515510 type Work @default.
- W1996515510 sameAs 1996515510 @default.
- W1996515510 citedByCount "38" @default.
- W1996515510 countsByYear W19965155102012 @default.
- W1996515510 countsByYear W19965155102013 @default.
- W1996515510 countsByYear W19965155102016 @default.
- W1996515510 countsByYear W19965155102018 @default.
- W1996515510 countsByYear W19965155102019 @default.
- W1996515510 countsByYear W19965155102020 @default.
- W1996515510 countsByYear W19965155102021 @default.
- W1996515510 crossrefType "journal-article" @default.
- W1996515510 hasAuthorship W1996515510A5036363062 @default.
- W1996515510 hasAuthorship W1996515510A5040610824 @default.
- W1996515510 hasAuthorship W1996515510A5051403739 @default.
- W1996515510 hasAuthorship W1996515510A5066110360 @default.
- W1996515510 hasAuthorship W1996515510A5068794661 @default.
- W1996515510 hasConcept C12554922 @default.
- W1996515510 hasConcept C160268369 @default.
- W1996515510 hasConcept C170493617 @default.
- W1996515510 hasConcept C181199279 @default.
- W1996515510 hasConcept C185592680 @default.
- W1996515510 hasConcept C189184402 @default.
- W1996515510 hasConcept C28406088 @default.
- W1996515510 hasConcept C4141045 @default.
- W1996515510 hasConcept C55493867 @default.
- W1996515510 hasConcept C56928146 @default.
- W1996515510 hasConcept C61174792 @default.
- W1996515510 hasConcept C67018056 @default.
- W1996515510 hasConcept C86803240 @default.
- W1996515510 hasConcept C98274493 @default.