Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996521391> ?p ?o ?g. }
- W1996521391 endingPage "333" @default.
- W1996521391 startingPage "321" @default.
- W1996521391 abstract "Elimination of viral infections is dependent on rapid recruitment of leucocytes to infected areas. Chemokines constitute a class of cytokines that regulate migration of leucocytes to sites of infection. In this work, the expression and function of CC chemokine receptor (CCR)1 and CCR5 and their ligands during a generalized herpes simplex virus type 2 (HSV-2) infection in mice were studied. Many CCR1 and CCR5 ligands were expressed in infected organs after intraperitoneal infection. In particular, CC chemokine expression in the liver preceded the expression of CCR1 and CCR5, suggesting recruitment of cells bearing these receptors, which correlated with a decrease in viral titres. Administration of Met-RANTES, a CCR1 and CCR5 antagonist, led to impaired antiviral response with significantly higher viral titre in the liver on days 1 and 6 after infection. This observation was accompanied by a decreased and shortened recruitment of natural killer cells to the peritoneum of infected mice treated with the antagonist. Despite this reduced recruitment of antiviral leucocytes in mice receiving Met-RANTES, peritoneal cells from these mice produced markedly enhanced levels of pro-inflammatory cytokines. Altogether, the results suggest that CCR1 and/or CCR5 are important for both viral clearance and eventual control of the immune response." @default.
- W1996521391 created "2016-06-24" @default.
- W1996521391 creator A5016922730 @default.
- W1996521391 creator A5082089381 @default.
- W1996521391 date "2004-03-01" @default.
- W1996521391 modified "2023-10-02" @default.
- W1996521391 title "Blocking CC Chemokine Receptor (CCR) 1 and CCR5 During Herpes Simplex Virus Type 2 Infection In Vivo Impairs Host Defence and Perturbs the Cytokine Response" @default.
- W1996521391 cites W1507898351 @default.
- W1996521391 cites W1508657985 @default.
- W1996521391 cites W1508832625 @default.
- W1996521391 cites W1522211409 @default.
- W1996521391 cites W1552604738 @default.
- W1996521391 cites W1563631631 @default.
- W1996521391 cites W1602000691 @default.
- W1996521391 cites W1673499395 @default.
- W1996521391 cites W1802262832 @default.
- W1996521391 cites W1905677550 @default.
- W1996521391 cites W1925291926 @default.
- W1996521391 cites W1954799708 @default.
- W1996521391 cites W1963871085 @default.
- W1996521391 cites W1966187637 @default.
- W1996521391 cites W1966288604 @default.
- W1996521391 cites W1968944419 @default.
- W1996521391 cites W1975742983 @default.
- W1996521391 cites W1977768701 @default.
- W1996521391 cites W1979382115 @default.
- W1996521391 cites W1980307352 @default.
- W1996521391 cites W1990559869 @default.
- W1996521391 cites W1996950781 @default.
- W1996521391 cites W2003426237 @default.
- W1996521391 cites W2005659566 @default.
- W1996521391 cites W2008221423 @default.
- W1996521391 cites W2012541226 @default.
- W1996521391 cites W2016539993 @default.
- W1996521391 cites W2020164587 @default.
- W1996521391 cites W2025768776 @default.
- W1996521391 cites W2029129294 @default.
- W1996521391 cites W2045385097 @default.
- W1996521391 cites W2050120409 @default.
- W1996521391 cites W2050439545 @default.
- W1996521391 cites W2059782047 @default.
- W1996521391 cites W2076538283 @default.
- W1996521391 cites W2078381704 @default.
- W1996521391 cites W2081769332 @default.
- W1996521391 cites W2082596959 @default.
- W1996521391 cites W2086196933 @default.
- W1996521391 cites W2093115501 @default.
- W1996521391 cites W2122299206 @default.
- W1996521391 cites W2124491055 @default.
- W1996521391 cites W2126210734 @default.
- W1996521391 cites W2133029085 @default.
- W1996521391 cites W2138585849 @default.
- W1996521391 cites W2142792546 @default.
- W1996521391 cites W2144423642 @default.
- W1996521391 cites W2144618266 @default.
- W1996521391 cites W2144789797 @default.
- W1996521391 cites W2147593691 @default.
- W1996521391 cites W2159194095 @default.
- W1996521391 cites W2159751862 @default.
- W1996521391 cites W2160129587 @default.
- W1996521391 cites W2160272188 @default.
- W1996521391 cites W2165766063 @default.
- W1996521391 cites W2166083796 @default.
- W1996521391 cites W2167935134 @default.
- W1996521391 cites W2167957992 @default.
- W1996521391 cites W4255634610 @default.
- W1996521391 cites W4299303240 @default.
- W1996521391 cites W4312464950 @default.
- W1996521391 cites W4313377103 @default.
- W1996521391 cites W1874589140 @default.
- W1996521391 doi "https://doi.org/10.1111/j.0300-9475.2004.01399.x" @default.
- W1996521391 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7169568" @default.
- W1996521391 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15030585" @default.
- W1996521391 hasPublicationYear "2004" @default.
- W1996521391 type Work @default.
- W1996521391 sameAs 1996521391 @default.
- W1996521391 citedByCount "27" @default.
- W1996521391 countsByYear W19965213912012 @default.
- W1996521391 countsByYear W19965213912013 @default.
- W1996521391 countsByYear W19965213912015 @default.
- W1996521391 countsByYear W19965213912016 @default.
- W1996521391 countsByYear W19965213912018 @default.
- W1996521391 countsByYear W19965213912019 @default.
- W1996521391 countsByYear W19965213912020 @default.
- W1996521391 countsByYear W19965213912021 @default.
- W1996521391 countsByYear W19965213912022 @default.
- W1996521391 crossrefType "journal-article" @default.
- W1996521391 hasAuthorship W1996521391A5016922730 @default.
- W1996521391 hasAuthorship W1996521391A5082089381 @default.
- W1996521391 hasBestOaLocation W19965213912 @default.
- W1996521391 hasConcept C12823836 @default.
- W1996521391 hasConcept C128879288 @default.
- W1996521391 hasConcept C129013479 @default.
- W1996521391 hasConcept C13373296 @default.
- W1996521391 hasConcept C150903083 @default.
- W1996521391 hasConcept C159047783 @default.
- W1996521391 hasConcept C170493617 @default.
- W1996521391 hasConcept C203014093 @default.