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- W1996522001 abstract "1. 1. A regulatory coupling between the rate of cellular transcription and the activity of topoisomerase I was investigated in plasmodia of Physarum polycephalum treated with fluorodeoxyuridine or nalidixic acid. 2. 2. Fluorodeoxyuridine at concentrations above 40 μg/ml lowered both the incorporation of [ 3 H]uridine and the activity of topoisomerase I to 10% of corresponding control values. 3. 3. Nalidixic acid, in the range of concentrations between 20–50 μg/ml did not inhibit the incorporation of [ 3 H]uridine but lowered the activity of topoisomerase I by about half. 4. 4. It is suggested that a coupling between the level of transcription and the activity of topoisomerase I in Physarum plasmodia involves only about a half of the topoisomerase I activity and is limited to transcription occurring on ribosomal genes." @default.
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- W1996522001 date "1992-08-01" @default.
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- W1996522001 title "Effects of fluorodeoxyuridine and nalidixic acid on the activity of topoisomerase I in plasmodia of Physarum polycephalum" @default.
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- W1996522001 doi "https://doi.org/10.1016/0020-711x(92)90205-f" @default.
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