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- W1996536472 abstract "In situ hybridization histochemistry was used to examine the expression of 10 GABAA receptor messenger RNAs corresponding to the α1–α5, β1–β3, γ1 and γ2 subunits in primary somatosensory and visual areas of macaque monkey cerebral cortex from embryonic day (E) 125 to postnatal day (P) 125. Results were compared with expression patterns in adults. In the sensorimotor cortex at E125, overall levels of all subunit transcripts were low. At E137, there was a major lamina-specific increase in all subunit messenger RNAs except γ1. For α1, α2, α4, β2, β3 and γ2 subunit transcripts, this increase was highest in areas 3a and 3b, particularly in layers III/IV and VI. Postnatally, there were significant decreases in all transcripts. α1, α5, β2 and γ2 subunit transcripts, while still at significantly lower levels than at E137, remained expressed at levels higher than other transcripts. Unlike in rodents, there was no obvious “switch” in the major subunits expressed in fetal and adult cortex, α1, α5, β2 and γ2 remaining highest throughout. In area 17, the most prominently expressed subunits at earliest ages were α2, α5, β1, β2, β3 and γ2, especially in layers II/III and VI. At E150, expression for α2, α3, β1 and β3 subunit transcripts in these layers decreased, but levels for α1, α4, α5, β2, γ1 and γ2 transcripts increased, particularly within layer IV. The increase at E150 was particularly marked for α5 transcripts, which were expressed at levels more than four times those of other transcripts. α1, β2 and γ2 remain highest into aduthood. Fetal area 17 displayed lamina-specific patterns of expression not found in adult animals. In particular, α3 messenger RNAs were present in layer IVA and γ1 transcripts were present in layer IVC at E150, despite a lack of expression in these layers in the adult. These data demonstrate increased expression of GABAA receptors during the period of establishment of thalamocortical and intracortical connections, and a temporal regulation that may be associated with the period of developmental plasticity." @default.
- W1996536472 created "2016-06-24" @default.
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- W1996536472 date "1999-07-01" @default.
- W1996536472 modified "2023-09-23" @default.
- W1996536472 title "Temporal modulation of GABAA receptor subunit gene expression in developing monkey cerebral cortex" @default.
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- W1996536472 doi "https://doi.org/10.1016/s0306-4522(98)00713-1" @default.
- W1996536472 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10391431" @default.
- W1996536472 hasPublicationYear "1999" @default.
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