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• W1996541308 abstract "P545 Aims: Chronic renal failure (CRF) is a recognized complication of organ transplantation and several risk factors there exist, linked both to patients and the procedure, which can favor its development. The aim of this study was to assess the incidence of post-transplantation CRF in a population of liver transplanted patients and to investigate the presence of possible risk factors for developing renal dysfunction. Methods: We performed a retrospective study on the liver-transplanted patients referring to liver transplantation ambulatory of “Tor Vergata” University of Rome and investigated the incidence of CRF and eventual need for renal replacement therapy (RRT). Furthermore, we searched for some possible risk factors for CRF development, such as systemic hypertension (SH), dyslipidemia, Diabetes Mellitus (DM), HBV and HCV status and calcyneurin inhibitors therapy. Results: From 1992 to today, 261 ortotopic liver transplantation have been performed at our Centre. In the post-transplantation period, 22 patients (8,4 %) developed chronic renal failure and were treated with standard intermittent hemodialysis (for a men time of 3 weeks). Among these, four male patients and one female subject have developed end stage renal disease (ESRD) and at present need chronic RRT. Further data about ESRD patients are reported in the Table below. One of them has died for cardiovascular complications during dialytic session.FigureAmong the remaining 17 patients, 5 subjects (29,5%) were HCV positive, 9/17 (52,9%) showed SH, 2/17 (11,8%) showed DM and 10/17 (58,8%) were treated with CsA. They partially recovered their renal function and are at present under conservative therapy. Conclusions: CRF proved to be a relatively common complication in our liver transplanted patients, confirming data reported in literature. Risk factors for developing renal dysfunction present in our patients are also cardiovascular risk factors and this could lead to an increase in mortality for cardiovascular pathology, particularly incident in uremic patients. It could be useful to pay attention to pre-transplant renal dysfunction, modifiable cardiovascular risk factors and immunosuppressant protocol in order to avoid CRF onset in liver transplanted patients, thus obtaining a reduction of morbidity and mortality and of the costs for the National Sanitary System." @default.
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• W1996541308 date "2004-07-01" @default.
• W1996541308 modified "2023-10-17" @default.
• W1996541308 title "CHRONIC RENAL FAILURE FOLLOWING ORTOTOPIC LIVER TRANSPLANTATION: AN EPIDEMIOLOGICAL STUDY." @default.
• W1996541308 doi "https://doi.org/10.1097/00007890-200407271-01040" @default.
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