Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996546207> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W1996546207 abstract "Despite significant progress in elucidating the pathogenesis of aneurysmal disease, the precise etiology of arterial wall degradation remains unclear. Numerous etiologies have been implicated, including stress-strain factors, structural wall abnormalities, and enzyme imbalance. We have previously shown that collagenase and elastase are increased in aortic aneurysm tissue. Herein we report and characterize a newly described serum compound that is able to hydrolyze an artificial elastase substrate but is not elastase. This substance is elevated in patients with atherosclerotic disease and, following aneurysmectomy, its concentration increases by threefold. Examination of the substance reveals that it is bound to lipid and consists of four subunits of molecular weights: 310,000, 62,000, 40,000, and 10,000 daltons. It has characteristics of thiol, carboxyl, and metalloenzymes and is most active at a pH of 7.0 to 8.0. A relationship between this serum compound and aneurysm tissue enzymatic activity is noted. We postulate that this serum compound may be produced by mononuclear cells and released into the serum. Furthermore, monocytes may enter the arterial wall intima and release this substance, resulting in proteolytic arterial wall degradation and subsequent aneurysm formation." @default.
- W1996546207 created "2016-06-24" @default.
- W1996546207 creator A5050437600 @default.
- W1996546207 creator A5063652015 @default.
- W1996546207 creator A5075909338 @default.
- W1996546207 date "1985-05-01" @default.
- W1996546207 modified "2023-09-24" @default.
- W1996546207 title "A new serum proteolytic enzyme in aneurysm pathogenesis" @default.
- W1996546207 cites W1483877097 @default.
- W1996546207 cites W1750773183 @default.
- W1996546207 cites W1982675479 @default.
- W1996546207 cites W1999724658 @default.
- W1996546207 cites W2006170518 @default.
- W1996546207 cites W2017039523 @default.
- W1996546207 cites W2022600831 @default.
- W1996546207 cites W2047849251 @default.
- W1996546207 cites W2134231332 @default.
- W1996546207 cites W2175237934 @default.
- W1996546207 cites W2411972046 @default.
- W1996546207 doi "https://doi.org/10.1067/mva.1985.avs0020393" @default.
- W1996546207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3889380" @default.
- W1996546207 hasPublicationYear "1985" @default.
- W1996546207 type Work @default.
- W1996546207 sameAs 1996546207 @default.
- W1996546207 citedByCount "11" @default.
- W1996546207 crossrefType "journal-article" @default.
- W1996546207 hasAuthorship W1996546207A5050437600 @default.
- W1996546207 hasAuthorship W1996546207A5063652015 @default.
- W1996546207 hasAuthorship W1996546207A5075909338 @default.
- W1996546207 hasConcept C126322002 @default.
- W1996546207 hasConcept C137627325 @default.
- W1996546207 hasConcept C141071460 @default.
- W1996546207 hasConcept C142724271 @default.
- W1996546207 hasConcept C181199279 @default.
- W1996546207 hasConcept C185592680 @default.
- W1996546207 hasConcept C2776098176 @default.
- W1996546207 hasConcept C2776714187 @default.
- W1996546207 hasConcept C2778394429 @default.
- W1996546207 hasConcept C2780942790 @default.
- W1996546207 hasConcept C2781044401 @default.
- W1996546207 hasConcept C2781307694 @default.
- W1996546207 hasConcept C3019223276 @default.
- W1996546207 hasConcept C3020090656 @default.
- W1996546207 hasConcept C55493867 @default.
- W1996546207 hasConcept C71924100 @default.
- W1996546207 hasConceptScore W1996546207C126322002 @default.
- W1996546207 hasConceptScore W1996546207C137627325 @default.
- W1996546207 hasConceptScore W1996546207C141071460 @default.
- W1996546207 hasConceptScore W1996546207C142724271 @default.
- W1996546207 hasConceptScore W1996546207C181199279 @default.
- W1996546207 hasConceptScore W1996546207C185592680 @default.
- W1996546207 hasConceptScore W1996546207C2776098176 @default.
- W1996546207 hasConceptScore W1996546207C2776714187 @default.
- W1996546207 hasConceptScore W1996546207C2778394429 @default.
- W1996546207 hasConceptScore W1996546207C2780942790 @default.
- W1996546207 hasConceptScore W1996546207C2781044401 @default.
- W1996546207 hasConceptScore W1996546207C2781307694 @default.
- W1996546207 hasConceptScore W1996546207C3019223276 @default.
- W1996546207 hasConceptScore W1996546207C3020090656 @default.
- W1996546207 hasConceptScore W1996546207C55493867 @default.
- W1996546207 hasConceptScore W1996546207C71924100 @default.
- W1996546207 hasLocation W19965462071 @default.
- W1996546207 hasLocation W19965462072 @default.
- W1996546207 hasOpenAccess W1996546207 @default.
- W1996546207 hasPrimaryLocation W19965462071 @default.
- W1996546207 hasRelatedWork W1994465526 @default.
- W1996546207 hasRelatedWork W1996546207 @default.
- W1996546207 hasRelatedWork W2003408138 @default.
- W1996546207 hasRelatedWork W2006053056 @default.
- W1996546207 hasRelatedWork W2050181999 @default.
- W1996546207 hasRelatedWork W2091793846 @default.
- W1996546207 hasRelatedWork W2152560885 @default.
- W1996546207 hasRelatedWork W2410036357 @default.
- W1996546207 hasRelatedWork W2434137922 @default.
- W1996546207 hasRelatedWork W2595945237 @default.
- W1996546207 isParatext "false" @default.
- W1996546207 isRetracted "false" @default.
- W1996546207 magId "1996546207" @default.
- W1996546207 workType "article" @default.