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- W1996554964 endingPage "286" @default.
- W1996554964 startingPage "277" @default.
- W1996554964 abstract "Transforming growth factor-β (TGF-β) is a multifunctional regulatory cytokine that is implicated in a variety of kidney diseases, including diabetic nephropathy and chronic transplant rejection, where it promotes stimulation of the extracellular matrix deposition, cell proliferation, and migration. TGF-β exerts its biological functions largely via its downstream complex signaling molecules, Smad proteins. Paradoxically, TGF-β also is essential for normal homeostasis and suppression of inflammation through mechanisms that are yet to be fully elucidated. One feasible mechanism by which TGF-β may exert its beneficial properties is through induction of heme oxygenase-1 (HO-1). Induction of this redox-sensitive enzyme is known to be cytoprotective through its potent antioxidant, anti-inflammatory, and anti-apoptotic properties in different conditions including several kidney diseases. In this overview, recent advances in our understanding of the role of TGF-β in kidney disease, its molecular regulation of HO-1 expression, and the potential role of HO-1 induction as a therapeutic modality in TGF-β–mediated kidney diseases are highlighted." @default.
- W1996554964 created "2016-06-24" @default.
- W1996554964 creator A5000953710 @default.
- W1996554964 creator A5066336399 @default.
- W1996554964 date "2012-05-01" @default.
- W1996554964 modified "2023-10-09" @default.
- W1996554964 title "Heme Oxygenase-1 as a Target for TGF-β in Kidney Disease" @default.
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