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- W1996557776 abstract "Mitochondrial dysfunction is involved in many neurodegenerative disorders in humans. Here we report mutations in a gene (designated levy) that codes for subunit VIa of cytochrome c oxidase (COX). The mutations were identified by the phenotype of temperature-induced paralysis and showed the additional phenotypes of decreased COX activity, age-dependent bang-induced paralysis, progressive neurodegeneration, and reduced life span. Germ-line transformation using the levy(+) gene rescued the mutant flies from all phenotypes including neurodegeneration. The data from levy mutants reveal a COX-mediated pathway in Drosophila, disruption of which leads to mitochondrial encephalomyopathic effects including neurodegeneration, motor dysfunction, and premature death. The data present the first case of a mutation in a nuclear-encoded structural subunit of COX that causes mitochondrial encephalomyopathy rather than lethality, whereas several previous attempts to identify such mutations have not been successful. The levy mutants provide a genetic model to understand the mechanisms underlying COX-mediated mitochondrial encephalomyopathies and to explore possible therapeutic interventions." @default.
- W1996557776 created "2016-06-24" @default.
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- W1996557776 date "2007-06-01" @default.
- W1996557776 modified "2023-09-26" @default.
- W1996557776 title "Mutations in Cytochrome c Oxidase Subunit VIa Cause Neurodegeneration and Motor Dysfunction in Drosophila" @default.
- W1996557776 cites W1495656425 @default.
- W1996557776 cites W1583826497 @default.
- W1996557776 cites W1622707836 @default.
- W1996557776 cites W1892860364 @default.
- W1996557776 cites W1904062914 @default.
- W1996557776 cites W1957389955 @default.
- W1996557776 cites W1967743863 @default.
- W1996557776 cites W1975355065 @default.
- W1996557776 cites W1977300781 @default.
- W1996557776 cites W1985221543 @default.
- W1996557776 cites W1986979437 @default.
- W1996557776 cites W1990668821 @default.
- W1996557776 cites W1995312770 @default.
- W1996557776 cites W1997198091 @default.
- W1996557776 cites W1997931335 @default.
- W1996557776 cites W1998932139 @default.
- W1996557776 cites W1999312292 @default.
- W1996557776 cites W2001801014 @default.
- W1996557776 cites W2006337128 @default.
- W1996557776 cites W2008143573 @default.
- W1996557776 cites W2016921033 @default.
- W1996557776 cites W2019148357 @default.
- W1996557776 cites W2019638599 @default.
- W1996557776 cites W2021272772 @default.
- W1996557776 cites W2024164720 @default.
- W1996557776 cites W2024880698 @default.
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- W1996557776 cites W2039207179 @default.
- W1996557776 cites W2039833162 @default.
- W1996557776 cites W2040358258 @default.
- W1996557776 cites W2041404754 @default.
- W1996557776 cites W2045416175 @default.
- W1996557776 cites W2049603263 @default.
- W1996557776 cites W2054297318 @default.
- W1996557776 cites W2056198198 @default.
- W1996557776 cites W2056789677 @default.
- W1996557776 cites W2059282884 @default.
- W1996557776 cites W2061797401 @default.
- W1996557776 cites W2066261651 @default.
- W1996557776 cites W2071965727 @default.
- W1996557776 cites W2072969519 @default.
- W1996557776 cites W2078666864 @default.
- W1996557776 cites W2079353889 @default.
- W1996557776 cites W2085633465 @default.
- W1996557776 cites W2088257156 @default.
- W1996557776 cites W2095626761 @default.
- W1996557776 cites W2097858454 @default.
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- W1996557776 cites W2137860960 @default.
- W1996557776 cites W2143370473 @default.
- W1996557776 cites W2149631006 @default.
- W1996557776 cites W2149639380 @default.
- W1996557776 cites W2149901817 @default.
- W1996557776 cites W2151271025 @default.
- W1996557776 cites W2151984737 @default.
- W1996557776 cites W2152437336 @default.
- W1996557776 cites W2158579182 @default.
- W1996557776 cites W2181132204 @default.
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- W1996557776 doi "https://doi.org/10.1534/genetics.107.071688" @default.
- W1996557776 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1894620" @default.
- W1996557776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17435251" @default.
- W1996557776 hasPublicationYear "2007" @default.
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