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• W1996558604 abstract "The purpose of this study was to examine what levels of hyperglycemia cause blood–brain barrier (BBB) disruption during permanent and transient middle cerebral artery occlusion in the rat and when the adverse effects of hyperglycemia occur. Cerebrovascular function was assessed by measuring the influx rate constant ( K i ) for 3 H-inulin and by measuring cerebral plasma ( 14 C-inulin) and 51 Cr-labeled red blood cell (RBC) volume. Different glucose protocols were used to produce mild sustained hyperglycemia (blood glucose ∼150mg/dL) or transient-severe hyperglycemia (with a spike in blood glucose of ∼ 400 mg/dL). As expected, transient-severe hyperglycemia at the time of occlusion induced marked BBB disruption in animals undergoing 2 h of ischemia with 2 h of reperfusion (25-fold increase in permeability compared with the contralateral core). However, the mild hyperglycemia model induced similar disruption. Similarly, after permanent occlusion, both hyperglycemia models enhanced disruption and they both produced marked (∼ 50%) reductions in cerebral plasma volume. Apparent cerebral RBC volume also decreased when measured during the final 5 mins of 2 h of ischemia with transient-severe hyperglycemia. However, there was no decrease if the 51 Cr-labeled RBCs were circulated for the whole 2 h, indicating RBC trapping. The spike in blood glucose in the severe hyperglycemia model was used to examine when hyperglycemia induced BBB disruption. Hyperglycemia shortly after occlusion caused severe disruption. In contrast, hyperglycemia after 90 mins of occlusion caused little disruption. These results suggest that mild hyperglycemia has a profound effect on BBB function and that very early correction of hyperglycemia is necessary to prevent adverse effects." @default.
• W1996558604 created "2016-06-24" @default.
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• W1996558604 date "2007-02-07" @default.
• W1996558604 modified "2023-10-13" @default.
• W1996558604 title "Effect of Sustained-Mild and Transient-Severe Hyperglycemia on Ischemia-Induced Blood–Brain Barrier Opening" @default.
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• W1996558604 doi "https://doi.org/10.1038/sj.jcbfm.9600454" @default.
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