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- W1996558708 abstract "The investigational drug Bucindolol has intrinsic sympathomimetic activity and direct vasodilating actions in animal models and adult humans with CHF and/or hypertension. Five children (2 1/2 - 21 mos; 4.0 - 10.4 kg) with ventricular septal defect or endocardial cushion defect and CHF had baseline pulmonary to systemic flow ratios (Qp/Qs) ≥ 3.0 at cardiac catheterization. After informed consent, each received a .05mg/kg, 5 min. infusion of Bucindolol. Hemodynamic measurements showed significant increases in pulmonary resistance/ systemic resistance (Rp/Rs), and Rp (Wood units); significant decreases, in indexed pulmonary flow (Qp), left to right shunt (L→R), and (Qp/Qs) in 100% of the children; but no significant change in pulmonary mean pressure (PA), aortic mean pressure (AO), Qs, Rs or indices of ventricular function. CHF improved transiently in all children and most dramatically in the ones with more severe CHF. The pre and post drug means (X̄) and mean % changes (% Δ) from pre drug values were: We conclude that Bucindolol is of potential value in managing CHF in infants with congenital heart lesions having high pulmonary flow." @default.
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- W1996558708 date "1984-04-01" @default.
- W1996558708 modified "2023-09-27" @default.
- W1996558708 title "THE HEMODYNAMIC EFFECTS OF BUCINDOLOL IN CHILDREN WITH CONGESTIVE HEART FAILURE (CHF)" @default.
- W1996558708 doi "https://doi.org/10.1203/00006450-198404001-00193" @default.
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