Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996571869> ?p ?o ?g. }
- W1996571869 endingPage "169" @default.
- W1996571869 startingPage "147" @default.
- W1996571869 abstract "Vitamin E (alpha-tocopherol), the principal chain-breaking antioxidant in biological membranes, prevents toxicant- and carcinogen-induced oxidative damage by trapping reactive oxyradicals. Although alpha-tocopherol antioxidant reactions appear to be not under direct metabolic control, alpha-tocopherol may function through redox cycles, which deliver reducing equivalents for antioxidant reactions and link antioxidant function to cellular metabolism. This review describes the antioxidant chemistry of alpha-tocopherol and evaluates the experimental evidence for the linkage of alpha-tocopherol turnover to cellular metabolism through redox cycles. Numerous in vitro experiments demonstrate antioxidant synergism between alpha-tocopherol and ascorbate, reduced glutathione, NADPH, and cellular electron transport proteins. Nevertheless, evidence that a one-electron redox cycle regenerates alpha-tocopherol from the tocopheroxyl radical is inconclusive. The difficulty of separating tocopheroxyl recycling from direct antioxidant actions of other antioxidants has complicated interpretation of the available data. A two-electron redox cycle involving alpha-tocopherol oxidation to 8a-substituted tocopherones followed by tocopherone reduction to alpha-tocopherol may occur, but would require enzymatic catalysis in vivo. Metabolism of antioxidant-inactive alpha-tocopheryl esters releases alpha-tocopherol, whereas reductive metabolism of alpha-tocopherylquinone, an alpha-tocopherol oxidation product, yields alpha-tocopherylhydroquinone, which also may provide antioxidant protection." @default.
- W1996571869 created "2016-06-24" @default.
- W1996571869 creator A5076297382 @default.
- W1996571869 date "1993-01-01" @default.
- W1996571869 modified "2023-10-06" @default.
- W1996571869 title "The Role of Metabolism in the Antioxidant Function of Vitamin E" @default.
- W1996571869 cites W103853784 @default.
- W1996571869 cites W12406526 @default.
- W1996571869 cites W142075626 @default.
- W1996571869 cites W1493945672 @default.
- W1996571869 cites W1500548354 @default.
- W1996571869 cites W1511013913 @default.
- W1996571869 cites W1545350562 @default.
- W1996571869 cites W1552806232 @default.
- W1996571869 cites W1559822664 @default.
- W1996571869 cites W1562095964 @default.
- W1996571869 cites W1583861109 @default.
- W1996571869 cites W1588874876 @default.
- W1996571869 cites W159617914 @default.
- W1996571869 cites W1598240089 @default.
- W1996571869 cites W1734082729 @default.
- W1996571869 cites W1861665218 @default.
- W1996571869 cites W1963820921 @default.
- W1996571869 cites W1964656478 @default.
- W1996571869 cites W1964691080 @default.
- W1996571869 cites W1964779956 @default.
- W1996571869 cites W1964859215 @default.
- W1996571869 cites W1966920840 @default.
- W1996571869 cites W1969167841 @default.
- W1996571869 cites W1975045923 @default.
- W1996571869 cites W1977406521 @default.
- W1996571869 cites W1981603740 @default.
- W1996571869 cites W1981813414 @default.
- W1996571869 cites W1983303750 @default.
- W1996571869 cites W1983455633 @default.
- W1996571869 cites W1983791991 @default.
- W1996571869 cites W1984276026 @default.
- W1996571869 cites W1985020078 @default.
- W1996571869 cites W1987078348 @default.
- W1996571869 cites W1987442873 @default.
- W1996571869 cites W1987702784 @default.
- W1996571869 cites W1988464187 @default.
- W1996571869 cites W1991422052 @default.
- W1996571869 cites W1992917154 @default.
- W1996571869 cites W1992917179 @default.
- W1996571869 cites W1993721886 @default.
- W1996571869 cites W1994516163 @default.
- W1996571869 cites W1996253777 @default.
- W1996571869 cites W1996814245 @default.
- W1996571869 cites W1999977358 @default.
- W1996571869 cites W2001712555 @default.
- W1996571869 cites W2002839475 @default.
- W1996571869 cites W2004335598 @default.
- W1996571869 cites W2005969177 @default.
- W1996571869 cites W2006947941 @default.
- W1996571869 cites W2007140957 @default.
- W1996571869 cites W2008765489 @default.
- W1996571869 cites W2008836533 @default.
- W1996571869 cites W2011705273 @default.
- W1996571869 cites W2013256347 @default.
- W1996571869 cites W2014009829 @default.
- W1996571869 cites W2017936168 @default.
- W1996571869 cites W2019436085 @default.
- W1996571869 cites W2019595790 @default.
- W1996571869 cites W2029237695 @default.
- W1996571869 cites W2029664522 @default.
- W1996571869 cites W2031923568 @default.
- W1996571869 cites W2033258307 @default.
- W1996571869 cites W2035635392 @default.
- W1996571869 cites W2035937807 @default.
- W1996571869 cites W2035971139 @default.
- W1996571869 cites W2036308819 @default.
- W1996571869 cites W2036572840 @default.
- W1996571869 cites W2038568679 @default.
- W1996571869 cites W2038996888 @default.
- W1996571869 cites W2042123465 @default.
- W1996571869 cites W2043423232 @default.
- W1996571869 cites W2043554708 @default.
- W1996571869 cites W2044018819 @default.
- W1996571869 cites W2044093977 @default.
- W1996571869 cites W2046103786 @default.
- W1996571869 cites W2046221075 @default.
- W1996571869 cites W2047610618 @default.
- W1996571869 cites W2050753146 @default.
- W1996571869 cites W2052293668 @default.
- W1996571869 cites W2052887354 @default.
- W1996571869 cites W2053254152 @default.
- W1996571869 cites W2054681056 @default.
- W1996571869 cites W2054939261 @default.
- W1996571869 cites W2057107323 @default.
- W1996571869 cites W2059149536 @default.
- W1996571869 cites W2059288625 @default.
- W1996571869 cites W2063252913 @default.
- W1996571869 cites W2065537789 @default.
- W1996571869 cites W2065601046 @default.
- W1996571869 cites W2066639890 @default.
- W1996571869 cites W2067093327 @default.
- W1996571869 cites W2069460849 @default.