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• W1996578032 abstract "Cannabinoids have emerged as powerful drug candidates for the treatment of inflammatory and autoimmune diseases due to their immunosuppressive properties. Significant clinical and experimental data on the use of cannabinoids as anti-inflammatory agents exist in many autoimmune disease settings, but virtually no studies have been undertaken on their potential role in transplant rejection. Here we suggest a theoretical role for the use of cannabinoids in preventing allograft rejection. The psychotropic properties of CB1 agonists limit their clinical use, but CB2 agonists may offer a new avenue to selectively target immune cells involved in allograft rejection. Moreover, development of mixed CB1/CB2 agonists that cannot cross the blood–brain barrier may help prevent their undesired psychotropic properties. In addition, manipulation of endocannabinoids in vivo by activating their biosynthesis and inhibiting cellular uptake and metabolism may offer another pathway to regulate immune response during allograft rejection. Cannabinoids have emerged as powerful drug candidates for the treatment of inflammatory and autoimmune diseases due to their immunosuppressive properties. Significant clinical and experimental data on the use of cannabinoids as anti-inflammatory agents exist in many autoimmune disease settings, but virtually no studies have been undertaken on their potential role in transplant rejection. Here we suggest a theoretical role for the use of cannabinoids in preventing allograft rejection. The psychotropic properties of CB1 agonists limit their clinical use, but CB2 agonists may offer a new avenue to selectively target immune cells involved in allograft rejection. Moreover, development of mixed CB1/CB2 agonists that cannot cross the blood–brain barrier may help prevent their undesired psychotropic properties. In addition, manipulation of endocannabinoids in vivo by activating their biosynthesis and inhibiting cellular uptake and metabolism may offer another pathway to regulate immune response during allograft rejection. are tetrophenolic compounds found in the plant Cannabis sativa. The natural cannabinoids discussed in this contribution are delta-9-tetrahydrocannabinol (THC), cannabidiol (CBD), and ajulemic acid (Aja). There are also synthetic compounds: JWH-015, JWH-133, HU-308, CP-55,940 and WIN-55,212-2. The two endocannabinoids mentioned in this article are anandamide (AEA) and 2-arachidonylglycerol (2-AG). is a major non-psychoactive cannabinoid component from Cannabis, constituting ≤40% in the extracts. It has potent anti-inflammatory and immunosuppressive effects in addition to its ability to alleviate convulsions, anxiety, nausea, and to inhibit tumor growth. comprises the endocannabinoids, cannabinoid receptors (CB1 and CB2), and the enzymes responsible for the synthesis and degradation of endocannabinoids. If the transplanted organ or tissue is genetically incompatible with the recipient, the donor's immune cells recognize the transplant as ‘foreign’ and mount a reaction, leading to transplant rejection. is transplantion of a tissue or organ between members of the same species. In the case of an allograft, the donor and the host are not genetically identical. As a result, the recipient rejects the donor transplant because the recipient's immune system recognizes the transplant as foreign. All human transplants from one person to another, except in the case of identical twins, are allografts. is a large gene family involved in the regulation of the vertebarte immune system. The antigens encoded by the MHC, present on the allograft, have a crucial role in transplant rejection. Human MHC molecules are referred to as human leukocyte antigens (HLAs). If grafted tissue has mature T cells, they can recognize the recipient's alloantigens as foreign and mount a reaction to destroy the host tissue, a phenomenon called graft-versus-host disease." @default.
• W1996578032 created "2016-06-24" @default.
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• W1996578032 date "2010-08-01" @default.
• W1996578032 modified "2023-09-22" @default.
• W1996578032 title "Do cannabinoids have a therapeutic role in transplantation?" @default.
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• W1996578032 doi "https://doi.org/10.1016/j.tips.2010.05.006" @default.
• W1996578032 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2923447" @default.
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• W1996578032 hasPublicationYear "2010" @default.
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