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- W1996589454 abstract "HPV vaccines available in the market are not effective against different strains of papillomavirus, therefore, there is a need to develop a new prophylactic DNA vaccine which can work against different strains of HPVs and may lead to protection of cervical cancer against new pandemic viruses. We designed a potential prophylactic DNA vaccine by using all the consensus epitopic sequences of HPVs L2 capsid protein and performed in silico cloning of multiepitopic antigenic DNA sequence in pVAX-1 vector. Immunogenicity of vaccine has been enhanced by techniques like codon optimization, engineering CpG motifs, introducing promoters and co-injection with plasmids expressing immune-stimulatory molecules." @default.
- W1996589454 created "2016-06-24" @default.
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- W1996589454 date "2009-12-01" @default.
- W1996589454 modified "2023-09-23" @default.
- W1996589454 title "In silico DNA vaccine designing against human papillomavirus (HPV) causing cervical cancer" @default.
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- W1996589454 doi "https://doi.org/10.1016/j.vaccine.2009.09.095" @default.
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