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• W1996590675 abstract "Prolonged alcohol exposure has been previously shown to impair the structure and function of the hippocampus, although the underlying structural and biochemical alterations contributing to these deleterious effects are unclear. Also unclear is whether these changes persist into prolonged periods of abstinence. Previous work from our lab utilizing a clinically relevant rodent model of alcohol consumption demonstrated that alcohol dependence (induced by chronic intermittent ethanol vapor exposure or CIE) decreases proliferation and survival of neural stem cells in the hippocampal subgranular zone and hippocampal neurogenesis in the dentate gyrus, implicating this region of the cortex as particularly sensitive to the toxic effects of prolonged ethanol exposure. For this study, we investigated seven weeks of CIE-induced morphological changes (dendritic complexity and dendritic spine density) of dentate gyrus (DG) granule cell neurons, CA3, and CA1 pyramidal neurons and the associated alterations in biochemical markers of synaptic plasticity and toxicity (NMDA receptors and PSD-95) in the hippocampus in ethanol-experienced Wistar rats 3 h (CIE) and 21 days (protracted abstinence) after the last ethanol vapor exposure. CIE reduced dendritic arborization of DG neurons and this effect persisted into protracted abstinence. CIE enhanced dendritic arborization of pyramidal neurons and this effect did not persist into protracted abstinence. The architectural changes in dendrites did not correlate with alterations in dendritic spine density, however, they were associated with increases in the expression of pNR2B, total NR2B, and total NR2A immediately following CIE with expression levels returning to control levels in prolonged abstinence. Overall, these data provide the evidence that CIE produces profound changes in hippocampal structural plasticity and in molecular tools that maintain hippocampal structural plasticity, and these alterations may underlie cognitive dysfunction associated with alcohol dependence. In addition, the compensatory state concurrent with reduced plasticity during protracted abstinence could leave the hippocampus vulnerable to subsequent insult following chronic ethanol exposure." @default.
• W1996590675 created "2016-06-24" @default.
• W1996590675 creator A5042670875 @default.
• W1996590675 creator A5043484602 @default.
• W1996590675 creator A5067737024 @default.
• W1996590675 date "2015-03-01" @default.
• W1996590675 modified "2023-09-26" @default.
• W1996590675 title "Dendritic remodeling of hippocampal neurons is associated with altered NMDA receptor expression in alcohol dependent rats" @default.
• W1996590675 cites W1515126555 @default.
• W1996590675 cites W1558650798 @default.
• W1996590675 cites W193454081 @default.
• W1996590675 cites W1965251357 @default.
• W1996590675 cites W1967256103 @default.
• W1996590675 cites W1970845405 @default.
• W1996590675 cites W1977137145 @default.
• W1996590675 cites W1977353942 @default.
• W1996590675 cites W1980306413 @default.
• W1996590675 cites W1986034435 @default.
• W1996590675 cites W1988544635 @default.
• W1996590675 cites W1990581763 @default.
• W1996590675 cites W1991449336 @default.
• W1996590675 cites W1992377856 @default.
• W1996590675 cites W1993988048 @default.
• W1996590675 cites W1994139890 @default.
• W1996590675 cites W1997396304 @default.
• W1996590675 cites W1998596728 @default.
• W1996590675 cites W1998708235 @default.
• W1996590675 cites W2001350759 @default.
• W1996590675 cites W2002247919 @default.
• W1996590675 cites W2005027803 @default.
• W1996590675 cites W2006754449 @default.
• W1996590675 cites W2006943025 @default.
• W1996590675 cites W2008521399 @default.
• W1996590675 cites W2009858032 @default.
• W1996590675 cites W2011230199 @default.
• W1996590675 cites W2017150789 @default.
• W1996590675 cites W2017908583 @default.
• W1996590675 cites W2018458388 @default.
• W1996590675 cites W2020972983 @default.
• W1996590675 cites W2022035248 @default.
• W1996590675 cites W2032681902 @default.
• W1996590675 cites W2035826919 @default.
• W1996590675 cites W2037877714 @default.
• W1996590675 cites W2045358091 @default.
• W1996590675 cites W2047007885 @default.
• W1996590675 cites W2047676891 @default.
• W1996590675 cites W2047735628 @default.
• W1996590675 cites W2054262036 @default.
• W1996590675 cites W2063016301 @default.
• W1996590675 cites W2063347908 @default.
• W1996590675 cites W2064111585 @default.
• W1996590675 cites W2066848874 @default.
• W1996590675 cites W2068985652 @default.
• W1996590675 cites W2072282121 @default.
• W1996590675 cites W2073342084 @default.
• W1996590675 cites W2076054987 @default.
• W1996590675 cites W2076090607 @default.
• W1996590675 cites W2077751480 @default.
• W1996590675 cites W2077844144 @default.
• W1996590675 cites W2078811276 @default.
• W1996590675 cites W2082619929 @default.
• W1996590675 cites W2084664557 @default.
• W1996590675 cites W2087086840 @default.
• W1996590675 cites W2087763856 @default.
• W1996590675 cites W2089429046 @default.
• W1996590675 cites W2089692573 @default.
• W1996590675 cites W2090930783 @default.
• W1996590675 cites W2099222699 @default.
• W1996590675 cites W2101249892 @default.
• W1996590675 cites W2106632036 @default.
• W1996590675 cites W2113204033 @default.
• W1996590675 cites W2115786262 @default.
• W1996590675 cites W2117264727 @default.
• W1996590675 cites W2123663795 @default.
• W1996590675 cites W2139358036 @default.
• W1996590675 cites W2141461869 @default.
• W1996590675 cites W2142371956 @default.
• W1996590675 cites W2151031844 @default.
• W1996590675 cites W2152055195 @default.
• W1996590675 cites W2155603196 @default.
• W1996590675 cites W2161039633 @default.
• W1996590675 cites W2164324679 @default.
• W1996590675 cites W2169826947 @default.
• W1996590675 cites W2171137970 @default.
• W1996590675 cites W2304153654 @default.
• W1996590675 cites W2402963534 @default.
• W1996590675 cites W2411474261 @default.
• W1996590675 cites W2415390891 @default.
• W1996590675 cites W2416855069 @default.
• W1996590675 cites W4245782910 @default.
• W1996590675 cites W4322703284 @default.
• W1996590675 doi "https://doi.org/10.1016/j.mcn.2015.03.008" @default.
• W1996590675 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4395499" @default.
• W1996590675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25769285" @default.
• W1996590675 hasPublicationYear "2015" @default.
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