Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996591010> ?p ?o ?g. }
- W1996591010 endingPage "e62002" @default.
- W1996591010 startingPage "e62002" @default.
- W1996591010 abstract "Cancer stem cells contribute to the malignant phenotypes of a variety of cancers, but markers to identify human hypopharyngeal cancer (HPC) stem cells remain poorly understood. Here, we report that the CD271+ population sorted from xenotransplanted HPCs possesses an enhanced tumor-initiating capability in immunodeficient mice. Tumors generated from the CD271+ cells contained both CD271+ and CD271− cells, indicating that the population could undergo differentiation. Immunohistological analyses of the tumors revealed that the CD271+ cells localized to a perivascular niche near CD34+ vasculature, to invasive fronts, and to the basal layer. In accordance with these characteristics, a stemness marker, Nanog, and matrix metalloproteinases (MMPs), which are implicated in cancer invasion, were significantly up-regulated in the CD271+ compared to the CD271− cell population. Furthermore, using primary HPC specimens, we demonstrated that high CD271 expression was correlated with a poor prognosis for patients. Taken together, our findings indicate that CD271 is a novel marker for HPC stem-like cells and for HPC prognosis." @default.
- W1996591010 created "2016-06-24" @default.
- W1996591010 creator A5011151476 @default.
- W1996591010 creator A5016185391 @default.
- W1996591010 creator A5023367894 @default.
- W1996591010 creator A5028675105 @default.
- W1996591010 creator A5029259830 @default.
- W1996591010 creator A5030034686 @default.
- W1996591010 creator A5049904267 @default.
- W1996591010 creator A5054908476 @default.
- W1996591010 creator A5056176484 @default.
- W1996591010 creator A5078110910 @default.
- W1996591010 creator A5087838405 @default.
- W1996591010 date "2013-04-23" @default.
- W1996591010 modified "2023-10-18" @default.
- W1996591010 title "CD271 Defines a Stem Cell-Like Population in Hypopharyngeal Cancer" @default.
- W1996591010 cites W1521305233 @default.
- W1996591010 cites W1656339735 @default.
- W1996591010 cites W1964903539 @default.
- W1996591010 cites W1974337916 @default.
- W1996591010 cites W1981299193 @default.
- W1996591010 cites W1982580620 @default.
- W1996591010 cites W1986863362 @default.
- W1996591010 cites W1990328283 @default.
- W1996591010 cites W1992514491 @default.
- W1996591010 cites W1992676863 @default.
- W1996591010 cites W1995102699 @default.
- W1996591010 cites W1997058342 @default.
- W1996591010 cites W1997725301 @default.
- W1996591010 cites W2000481222 @default.
- W1996591010 cites W2019199359 @default.
- W1996591010 cites W2019264784 @default.
- W1996591010 cites W2020131167 @default.
- W1996591010 cites W2020830322 @default.
- W1996591010 cites W2023263348 @default.
- W1996591010 cites W2023427658 @default.
- W1996591010 cites W2025567248 @default.
- W1996591010 cites W2038531943 @default.
- W1996591010 cites W2043746859 @default.
- W1996591010 cites W2052981459 @default.
- W1996591010 cites W2056992430 @default.
- W1996591010 cites W2060551076 @default.
- W1996591010 cites W2066586420 @default.
- W1996591010 cites W2076819072 @default.
- W1996591010 cites W2090982381 @default.
- W1996591010 cites W2100989340 @default.
- W1996591010 cites W2103489164 @default.
- W1996591010 cites W2105241495 @default.
- W1996591010 cites W2110238167 @default.
- W1996591010 cites W2115210857 @default.
- W1996591010 cites W2124366353 @default.
- W1996591010 cites W2126851387 @default.
- W1996591010 cites W2132807647 @default.
- W1996591010 cites W2138784667 @default.
- W1996591010 cites W2140320332 @default.
- W1996591010 cites W2141037581 @default.
- W1996591010 cites W2145961505 @default.
- W1996591010 cites W2150163104 @default.
- W1996591010 cites W2153101406 @default.
- W1996591010 cites W2159640574 @default.
- W1996591010 cites W2162639860 @default.
- W1996591010 doi "https://doi.org/10.1371/journal.pone.0062002" @default.
- W1996591010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3633921" @default.
- W1996591010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23626764" @default.
- W1996591010 hasPublicationYear "2013" @default.
- W1996591010 type Work @default.
- W1996591010 sameAs 1996591010 @default.
- W1996591010 citedByCount "47" @default.
- W1996591010 countsByYear W19965910102014 @default.
- W1996591010 countsByYear W19965910102015 @default.
- W1996591010 countsByYear W19965910102016 @default.
- W1996591010 countsByYear W19965910102017 @default.
- W1996591010 countsByYear W19965910102018 @default.
- W1996591010 countsByYear W19965910102019 @default.
- W1996591010 countsByYear W19965910102020 @default.
- W1996591010 countsByYear W19965910102021 @default.
- W1996591010 countsByYear W19965910102022 @default.
- W1996591010 countsByYear W19965910102023 @default.
- W1996591010 crossrefType "journal-article" @default.
- W1996591010 hasAuthorship W1996591010A5011151476 @default.
- W1996591010 hasAuthorship W1996591010A5016185391 @default.
- W1996591010 hasAuthorship W1996591010A5023367894 @default.
- W1996591010 hasAuthorship W1996591010A5028675105 @default.
- W1996591010 hasAuthorship W1996591010A5029259830 @default.
- W1996591010 hasAuthorship W1996591010A5030034686 @default.
- W1996591010 hasAuthorship W1996591010A5049904267 @default.
- W1996591010 hasAuthorship W1996591010A5054908476 @default.
- W1996591010 hasAuthorship W1996591010A5056176484 @default.
- W1996591010 hasAuthorship W1996591010A5078110910 @default.
- W1996591010 hasAuthorship W1996591010A5087838405 @default.
- W1996591010 hasBestOaLocation W19965910101 @default.
- W1996591010 hasConcept C10205521 @default.
- W1996591010 hasConcept C104317684 @default.
- W1996591010 hasConcept C107459253 @default.
- W1996591010 hasConcept C121608353 @default.
- W1996591010 hasConcept C136302470 @default.
- W1996591010 hasConcept C142724271 @default.
- W1996591010 hasConcept C145103041 @default.