FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996594421> ?p ?o ?g. }

• W1996594421 endingPage "425" @default.
• W1996594421 startingPage "417" @default.
• W1996594421 abstract "Alpha-fetoprotein (AFP) computational secreted network construction and analysis of human hepatocellular carcinoma (HCC) is very useful to identify novel markers and potential targets for prognosis and therapy. By integration of gene regulatory network infer and the database for annotation, visualization, and integrated discovery, we identified and constructed significant molecule AFP secreted network from 25 no-tumor hepatitis/cirrhotic liver tissues and 25 HCC patients in the same GEO Dataset GSE10140-10141. Our result verified AFP secreted module in the upstream of no-tumor hepatitis/cirrhotic liver tissues (AMELY, LCN2, and REG3A activation; DKK1, SFRP4, and SPINK1 inhibition) and its downstream (PRSS1, REG3A, and TSHB activation; AMELY and DKK1 inhibition), and also in the upstream of HCC (LCN2, REG3A, and SFRP4 activation; AMELY and DKK1 inhibition) and its downstream (AMELY activation; DKK1, LCN2, PRSS1, SEMA3B, and SPINK1 inhibition). Importantly, we data-mined that AFP secreted cluster of HCC is involved in disease mutation (only in HCC terms) without cell surface receptor linked signal transduction, neuroactive ligand-receptor interaction, cell-cell signaling, and pancreas (only in no-tumor hepatitis/cirrhotic liver tissues terms), the condition which is vital to invasion of HCC. Our result demonstrated that common terms in both no-tumor hepatitis/cirrhotic liver tissues and HCC include secreted extracellular region, extracellular region part, extracellular space, signal peptide, signal, disulfide bond, glycosylation site N-linked (GlcNAc...), and glycoprotein, and these terms are less relative to invasion; therefore, we deduced the weaker AFP secreted network in HCC consistent with our number computation. We predicted AFP high expression localization within cells of HCC and without secretion to extracellular matrix. It would be necessary of AFP secreted function to decrease invasion of HCC." @default.
• W1996594421 created "2016-06-24" @default.
• W1996594421 creator A5015722650 @default.
• W1996594421 creator A5034844592 @default.
• W1996594421 creator A5066523907 @default.
• W1996594421 creator A5075901074 @default.
• W1996594421 date "2010-06-08" @default.
• W1996594421 modified "2023-09-30" @default.
• W1996594421 title "AFP computational secreted network construction and analysis between human hepatocellular carcinoma (HCC) and no-tumor hepatitis/cirrhotic liver tissues" @default.
• W1996594421 cites W1493851392 @default.
• W1996594421 cites W1964689881 @default.
• W1996594421 cites W1972570834 @default.
• W1996594421 cites W1990476501 @default.
• W1996594421 cites W1991102078 @default.
• W1996594421 cites W1994986431 @default.
• W1996594421 cites W2003783688 @default.
• W1996594421 cites W2004255275 @default.
• W1996594421 cites W2009671859 @default.
• W1996594421 cites W2010600910 @default.
• W1996594421 cites W2012122630 @default.
• W1996594421 cites W2022629609 @default.
• W1996594421 cites W2040881027 @default.
• W1996594421 cites W2044592867 @default.
• W1996594421 cites W2052322789 @default.
• W1996594421 cites W2054292449 @default.
• W1996594421 cites W2059579018 @default.
• W1996594421 cites W2074648081 @default.
• W1996594421 cites W2094817063 @default.
• W1996594421 cites W2097795961 @default.
• W1996594421 cites W2100584995 @default.
• W1996594421 cites W2105381419 @default.
• W1996594421 cites W2112233652 @default.
• W1996594421 cites W2122683221 @default.
• W1996594421 cites W2133993485 @default.
• W1996594421 cites W2151765870 @default.
• W1996594421 cites W2153283984 @default.
• W1996594421 cites W2163296862 @default.
• W1996594421 cites W2184188092 @default.
• W1996594421 cites W322093559 @default.
• W1996594421 doi "https://doi.org/10.1007/s13277-010-0050-8" @default.
• W1996594421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20532728" @default.
• W1996594421 hasPublicationYear "2010" @default.
• W1996594421 type Work @default.
• W1996594421 sameAs 1996594421 @default.
• W1996594421 citedByCount "38" @default.
• W1996594421 countsByYear W19965944212012 @default.
• W1996594421 countsByYear W19965944212013 @default.
• W1996594421 countsByYear W19965944212014 @default.
• W1996594421 countsByYear W19965944212015 @default.
• W1996594421 countsByYear W19965944212016 @default.
• W1996594421 countsByYear W19965944212017 @default.
• W1996594421 countsByYear W19965944212019 @default.
• W1996594421 countsByYear W19965944212020 @default.
• W1996594421 countsByYear W19965944212021 @default.
• W1996594421 crossrefType "journal-article" @default.
• W1996594421 hasAuthorship W1996594421A5015722650 @default.
• W1996594421 hasAuthorship W1996594421A5034844592 @default.
• W1996594421 hasAuthorship W1996594421A5066523907 @default.
• W1996594421 hasAuthorship W1996594421A5075901074 @default.
• W1996594421 hasConcept C2776231280 @default.
• W1996594421 hasConcept C2778019345 @default.
• W1996594421 hasConcept C502942594 @default.
• W1996594421 hasConcept C62478195 @default.
• W1996594421 hasConcept C86803240 @default.
• W1996594421 hasConcept C95444343 @default.
• W1996594421 hasConceptScore W1996594421C2776231280 @default.
• W1996594421 hasConceptScore W1996594421C2778019345 @default.
• W1996594421 hasConceptScore W1996594421C502942594 @default.
• W1996594421 hasConceptScore W1996594421C62478195 @default.
• W1996594421 hasConceptScore W1996594421C86803240 @default.
• W1996594421 hasConceptScore W1996594421C95444343 @default.
• W1996594421 hasIssue "5" @default.
• W1996594421 hasLocation W19965944211 @default.
• W1996594421 hasLocation W19965944212 @default.
• W1996594421 hasOpenAccess W1996594421 @default.
• W1996594421 hasPrimaryLocation W19965944211 @default.
• W1996594421 hasRelatedWork W2020483997 @default.
• W1996594421 hasRelatedWork W2021080195 @default.
• W1996594421 hasRelatedWork W2328603980 @default.
• W1996594421 hasRelatedWork W2587321528 @default.
• W1996594421 hasRelatedWork W3022463795 @default.
• W1996594421 hasRelatedWork W3091218766 @default.
• W1996594421 hasRelatedWork W3091350106 @default.
• W1996594421 hasRelatedWork W3143873275 @default.
• W1996594421 hasRelatedWork W3178156607 @default.
• W1996594421 hasRelatedWork W4383315843 @default.
• W1996594421 hasVolume "31" @default.
• W1996594421 isParatext "false" @default.
• W1996594421 isRetracted "false" @default.
• W1996594421 magId "1996594421" @default.
• W1996594421 workType "article" @default.