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• W1996598832 abstract "Because histidine-rich glycoprotein binds to the kringle 1-3 domain of plasminogen, it may affect fibrinolysis by reducing fibrin-dependent plasmin production, and in this way it could be mechanistically analogous to 6-aminohexanoic acid. We tested this hypothesis by comparing the effects of histidine-rich glycoprotein and 6-aminohexanoic acid in an in vitro assay of fibrin-dependent plasmin production mediated by tissue plasminogen activator. Whereas 1 mM of 6-aminohexanoic acid increased the K(m) of the reaction from approximately 0.22 microM to approximately 1.7 microM, 2 microM of histidine-rich glycoprotein had no discernible effect. Similar results were obtained in an assay based upon fibrin clot lysis. Therefore, we could not document an effect of histidine-rich glycoprotein on the rate of fibrin-dependent plasmin production." @default.
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• W1996598832 date "2000-07-01" @default.
• W1996598832 modified "2023-10-18" @default.
• W1996598832 title "Comparison of the Effect of Histidine-Rich Glycoprotein and 6-Aminohexanoic Acid on Plasmin Production and Fibrinolysis in Vitro" @default.
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• W1996598832 doi "https://doi.org/10.1016/s0049-3848(00)00231-0" @default.
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