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- W1996609898 abstract "Long-term outcomes of combined cinacalcet and paricalcitol therapy for secondary hyperparathyroidism (SHPT) in patients failing traditional therapies with phosphate binders and active vitamin D compound analogs are not well described. We implemented a titration protocol for cinacalcet and paricalcitol and assessed its long-term effects on bone metabolism and disease in hemodialysis (HD) patients. Thirty-five patients were started on 30 mg of cinacalcet daily. After 12 months, median cinacalcet dose was 60 mg. There was a 33% increase in number of patients receiving paricalcitol. Average corrected serum calcium (Ca) decreased from 9.5 to 8.8 mg/dl (p = 0.003, 95% CI 0.34–1.04); phosphorus (P) from 6.2 to 5.5 mg/dl (p = 0.047, 95% CI 0.01–1.34); Ca × P product from 58 to 48 (p = 0.001, 95% CI 4.2–15.7); and intact PTH (iPTH) from 426 ± 274 to 300 ± 228 pg/ml (p = 0.03, 95% CI 19.3–401.7). Number of patients achieving three or more K/DOQI criteria increased by 29% (p = 0.009)." @default.
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- W1996609898 date "2007-01-01" @default.
- W1996609898 modified "2023-09-27" @default.
- W1996609898 title "Long-Term Outcomes of Cinacalcet and Paricalcitol Titration Protocol for Treatment of Secondary Hyperparathyroidism" @default.
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- W1996609898 doi "https://doi.org/10.1159/000101727" @default.
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