FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996620164> ?p ?o ?g. }

• W1996620164 endingPage "1286" @default.
• W1996620164 startingPage "1285" @default.
• W1996620164 abstract "I am curious about the reasons that prompted the twin editorials on dexamethasone for postoperative nausea and vomiting (PONV) in September's edition of Anaesthesia 1, 2, especially ‘the case against’ raised by Drs Hartle & Bartlett 2. A number of published articles over the last 15 years provide evidence that a single prophylactic dose of the potent corticosteroid dexamethasone can safely reduce the likelihood of sickness after general anaesthesia. The use of dexamethasone as an antiemetic is recommended in the Royal College of Anaesthetists' 2012 Basic Level Training guide 3 and in the Association of Paediatric Anaesthetists of Great Britain and Ireland's 2008 guidelines 4. In Reading, since 2004, we have used a PONV protocol based on Apfel et al.'s simplified scoring system of four factors (female sex, history of motion sickness or PONV, non-smoking and use of postoperative opioids) 5; patients with any one of these are prescribed prophylactic antiemetics if they undergo general anaesthesia, and those with any three receive total intravenous anaesthesia (TIVA), rather than volatile agents. Dexamethasone has been the inexpensive first-line choice, partly because it enhances the patients' mood, but also because it is a superior antiemetic to propofol TIVA in the first 24 hours postoperatively 6. The combination of dexamethasone and ondansetron remains a popular choice for female non-smokers. Admissions for PONV after day-case surgery are rare. We have not seen gastric ulceration or psychiatric disturbance. A single dose of dexamethasone is administered to diabetics with prolonged PONV that interferes with oral intake of food, without disturbance of their blood sugar control. On visiting Kehlet's group in Copenhagen, we learned that widespread use of dexamethasone was not associated with any increase in postoperative infection in arthroplasty patients. Neither editorial mentioned that use of dexamethasone as a prophylactic antiemetic lies outside the manufacturer's marketing authorisation. The General Medical Council advises doctors to use drugs that are licensed for a particular indication in preference to those that lack a marketing authorisation for that purpose. In advocating elective treatment with a drug that is ‘off-label’, specific informed consent should be sought from the patient pre-operatively 7. The Royal College of Anaesthetists helpfully provide written information to this end, that can be provided for patients at pre-operative assessment clinics or by direction to the website 8." @default.
• W1996620164 created "2016-06-24" @default.
• W1996620164 creator A5047202468 @default.
• W1996620164 date "2013-11-12" @default.
• W1996620164 modified "2023-09-27" @default.
• W1996620164 title "Guidelines and use of dexamethasone for postoperative nausea and vomiting" @default.
• W1996620164 cites W2004153137 @default.
• W1996620164 cites W2027206415 @default.
• W1996620164 cites W2154735290 @default.
• W1996620164 cites W4231039135 @default.
• W1996620164 doi "https://doi.org/10.1111/anae.12513" @default.
• W1996620164 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24219271" @default.
• W1996620164 hasPublicationYear "2013" @default.
• W1996620164 type Work @default.
• W1996620164 sameAs 1996620164 @default.
• W1996620164 citedByCount "2" @default.
• W1996620164 countsByYear W19966201642016 @default.
• W1996620164 countsByYear W19966201642019 @default.
• W1996620164 crossrefType "journal-article" @default.
• W1996620164 hasAuthorship W1996620164A5047202468 @default.
• W1996620164 hasBestOaLocation W19966201641 @default.
• W1996620164 hasConcept C126322002 @default.
• W1996620164 hasConcept C141071460 @default.
• W1996620164 hasConcept C2776983577 @default.
• W1996620164 hasConcept C2777170512 @default.
• W1996620164 hasConcept C2777297131 @default.
• W1996620164 hasConcept C2780401358 @default.
• W1996620164 hasConcept C2780580376 @default.
• W1996620164 hasConcept C2780852908 @default.
• W1996620164 hasConcept C2780884295 @default.
• W1996620164 hasConcept C42219234 @default.
• W1996620164 hasConcept C71924100 @default.
• W1996620164 hasConceptScore W1996620164C126322002 @default.
• W1996620164 hasConceptScore W1996620164C141071460 @default.
• W1996620164 hasConceptScore W1996620164C2776983577 @default.
• W1996620164 hasConceptScore W1996620164C2777170512 @default.
• W1996620164 hasConceptScore W1996620164C2777297131 @default.
• W1996620164 hasConceptScore W1996620164C2780401358 @default.
• W1996620164 hasConceptScore W1996620164C2780580376 @default.
• W1996620164 hasConceptScore W1996620164C2780852908 @default.
• W1996620164 hasConceptScore W1996620164C2780884295 @default.
• W1996620164 hasConceptScore W1996620164C42219234 @default.
• W1996620164 hasConceptScore W1996620164C71924100 @default.
• W1996620164 hasIssue "12" @default.
• W1996620164 hasLocation W19966201641 @default.
• W1996620164 hasLocation W19966201642 @default.
• W1996620164 hasOpenAccess W1996620164 @default.
• W1996620164 hasPrimaryLocation W19966201641 @default.
• W1996620164 hasRelatedWork W1768571168 @default.
• W1996620164 hasRelatedWork W1824703102 @default.
• W1996620164 hasRelatedWork W1862213284 @default.
• W1996620164 hasRelatedWork W2057593650 @default.
• W1996620164 hasRelatedWork W2096917975 @default.
• W1996620164 hasRelatedWork W2152116480 @default.
• W1996620164 hasRelatedWork W2155294684 @default.
• W1996620164 hasRelatedWork W2563903067 @default.
• W1996620164 hasRelatedWork W2608768624 @default.
• W1996620164 hasRelatedWork W2885219537 @default.
• W1996620164 hasVolume "68" @default.
• W1996620164 isParatext "false" @default.
• W1996620164 isRetracted "false" @default.
• W1996620164 magId "1996620164" @default.
• W1996620164 workType "article" @default.