Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996624877> ?p ?o ?g. }
- W1996624877 endingPage "2128" @default.
- W1996624877 startingPage "2120" @default.
- W1996624877 abstract "Abstract Merkel cell carcinoma (MCC) is a rare and highly aggressive skin cancer associated with the Merkel cell polyomavirus (MCV). As MCC cell lines show oncogene addiction to the MCV T antigens, pharmacologic interference of the large T antigen (LTA) may represent an effective therapeutic approach for this deadly cancer. In this study, we investigated the effects of IFNs on MCC cell lines, especially on MCV-positive (MCV+) lines. Type I IFNs (i.e., Multiferon, a mix of different IFN-α subtypes, and IFN-β) strongly inhibited the cellular viability. Cell-cycle analysis showed increased sub-G fractions for these cells upon IFN treatment indicating apoptotic cell death; these effects were less pronounced for IFN-γ. Notably, this inhibitory effect of type I IFNs on MCV+ MCC cell lines was associated with a reduced expression of the MCV LTA as well as an increased expression of promyelocytic leukemia (PML) protein, which is known to interfere with the function of the LTA. In addition, the intratumoral application of Multiferon resulted in a regression of MCV+ but not MCV− MCCs in vivo. Together, our findings show that type I IFNs have a strong antitumor effect, which is at least in part explained by modulation of the virally encoded LTA. Cancer Res; 72(8); 2120–8. ©2012 AACR." @default.
- W1996624877 created "2016-06-24" @default.
- W1996624877 creator A5005332655 @default.
- W1996624877 creator A5010522579 @default.
- W1996624877 creator A5025463753 @default.
- W1996624877 creator A5054913838 @default.
- W1996624877 creator A5058138470 @default.
- W1996624877 creator A5061716251 @default.
- W1996624877 creator A5072510059 @default.
- W1996624877 date "2012-04-15" @default.
- W1996624877 modified "2023-10-16" @default.
- W1996624877 title "Type I and II IFNs Inhibit Merkel Cell Carcinoma via Modulation of the Merkel Cell Polyomavirus T Antigens" @default.
- W1996624877 cites W1966536433 @default.
- W1996624877 cites W1967471735 @default.
- W1996624877 cites W1968174514 @default.
- W1996624877 cites W1968697793 @default.
- W1996624877 cites W1969234386 @default.
- W1996624877 cites W1969379547 @default.
- W1996624877 cites W1973704821 @default.
- W1996624877 cites W1978048533 @default.
- W1996624877 cites W1991597167 @default.
- W1996624877 cites W1992496728 @default.
- W1996624877 cites W1994008354 @default.
- W1996624877 cites W1996583727 @default.
- W1996624877 cites W1996976569 @default.
- W1996624877 cites W1998403323 @default.
- W1996624877 cites W2010744805 @default.
- W1996624877 cites W2011374571 @default.
- W1996624877 cites W2022754087 @default.
- W1996624877 cites W2028845506 @default.
- W1996624877 cites W2032064870 @default.
- W1996624877 cites W2034045161 @default.
- W1996624877 cites W2034081065 @default.
- W1996624877 cites W2034359832 @default.
- W1996624877 cites W2047052568 @default.
- W1996624877 cites W2051924129 @default.
- W1996624877 cites W2055279590 @default.
- W1996624877 cites W2056750070 @default.
- W1996624877 cites W2060926084 @default.
- W1996624877 cites W2074544844 @default.
- W1996624877 cites W2079094248 @default.
- W1996624877 cites W2080119374 @default.
- W1996624877 cites W2083691502 @default.
- W1996624877 cites W2084970371 @default.
- W1996624877 cites W2085487956 @default.
- W1996624877 cites W2091204394 @default.
- W1996624877 cites W2096012548 @default.
- W1996624877 cites W2097898173 @default.
- W1996624877 cites W2119749824 @default.
- W1996624877 cites W2139005449 @default.
- W1996624877 cites W2139168442 @default.
- W1996624877 cites W2140604236 @default.
- W1996624877 cites W2145965676 @default.
- W1996624877 cites W2151320496 @default.
- W1996624877 cites W2159895854 @default.
- W1996624877 cites W2167017590 @default.
- W1996624877 cites W2276234997 @default.
- W1996624877 doi "https://doi.org/10.1158/0008-5472.can-11-2651" @default.
- W1996624877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22389452" @default.
- W1996624877 hasPublicationYear "2012" @default.
- W1996624877 type Work @default.
- W1996624877 sameAs 1996624877 @default.
- W1996624877 citedByCount "45" @default.
- W1996624877 countsByYear W19966248772012 @default.
- W1996624877 countsByYear W19966248772013 @default.
- W1996624877 countsByYear W19966248772014 @default.
- W1996624877 countsByYear W19966248772015 @default.
- W1996624877 countsByYear W19966248772016 @default.
- W1996624877 countsByYear W19966248772017 @default.
- W1996624877 countsByYear W19966248772018 @default.
- W1996624877 countsByYear W19966248772019 @default.
- W1996624877 countsByYear W19966248772020 @default.
- W1996624877 countsByYear W19966248772021 @default.
- W1996624877 countsByYear W19966248772022 @default.
- W1996624877 countsByYear W19966248772023 @default.
- W1996624877 crossrefType "journal-article" @default.
- W1996624877 hasAuthorship W1996624877A5005332655 @default.
- W1996624877 hasAuthorship W1996624877A5010522579 @default.
- W1996624877 hasAuthorship W1996624877A5025463753 @default.
- W1996624877 hasAuthorship W1996624877A5054913838 @default.
- W1996624877 hasAuthorship W1996624877A5058138470 @default.
- W1996624877 hasAuthorship W1996624877A5061716251 @default.
- W1996624877 hasAuthorship W1996624877A5072510059 @default.
- W1996624877 hasConcept C121608353 @default.
- W1996624877 hasConcept C147483822 @default.
- W1996624877 hasConcept C1491633281 @default.
- W1996624877 hasConcept C203014093 @default.
- W1996624877 hasConcept C2776090121 @default.
- W1996624877 hasConcept C2776187983 @default.
- W1996624877 hasConcept C2777546739 @default.
- W1996624877 hasConcept C2778342957 @default.
- W1996624877 hasConcept C2780291066 @default.
- W1996624877 hasConcept C2781018059 @default.
- W1996624877 hasConcept C29537977 @default.
- W1996624877 hasConcept C502942594 @default.
- W1996624877 hasConcept C54355233 @default.
- W1996624877 hasConcept C81885089 @default.
- W1996624877 hasConcept C86803240 @default.