Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996632693> ?p ?o ?g. }
- W1996632693 endingPage "7" @default.
- W1996632693 startingPage "1" @default.
- W1996632693 abstract "It has been shown that the transient receptor potential channel vanilloid type 1 (TRPV1) is able to sense a vast range of stimuli and exerts multiple functions under physiological or pathophysiological conditions. TRPV1 not only plays a fundamental role in pain signaling but also involves in many other physiological or pathophysiological functions including the beneficial effects on cardiovascular and gastrointestinal function. It has been found that TRPV1 could be activated by endogenous ligands such as anandamide, N-arachidonoyl dopamine and N-oleoyldopamine or by exogenous agonists such as capsaicin and rutaecarpine. Since capsaicin-sensitive sensory nerves (rich in TRPV1) are densely distributed in the cardiovascular and gastrointestinal system, activation of TRPV1 either by endogenous ligands or by exogenous agonists has been repeatedly reported to exert hypotensive effects or protective effects against cardiac or gastrointestinal injury through stimulating the synthesis and release of multiple neurotransmitters such as calcitonin gene-related peptide and substance P. Therefore, TRPV1 is not only a prime target for the pharmacological control of pain but also a useful target for drug development to treat various diseases including cardiovascular and gastrointestinal diseases. However, considering the contribution of TRPV1 to the development of inflammation in the gastrointestinal tract, the potential side effects of TRPV1 agonist cannot be neglected while in seeking and developing the novel TRPV1 agonists." @default.
- W1996632693 created "2016-06-24" @default.
- W1996632693 creator A5015229643 @default.
- W1996632693 creator A5066058994 @default.
- W1996632693 date "2010-02-01" @default.
- W1996632693 modified "2023-09-26" @default.
- W1996632693 title "The vanilloid receptor TRPV1: Role in cardiovascular and gastrointestinal protection" @default.
- W1996632693 cites W129439908 @default.
- W1996632693 cites W1511198581 @default.
- W1996632693 cites W1584650885 @default.
- W1996632693 cites W1593645241 @default.
- W1996632693 cites W1629231131 @default.
- W1996632693 cites W1964302331 @default.
- W1996632693 cites W1967619779 @default.
- W1996632693 cites W1967863888 @default.
- W1996632693 cites W1967997577 @default.
- W1996632693 cites W1973584618 @default.
- W1996632693 cites W1973633894 @default.
- W1996632693 cites W1976621999 @default.
- W1996632693 cites W1978598856 @default.
- W1996632693 cites W1978673470 @default.
- W1996632693 cites W1980209044 @default.
- W1996632693 cites W1980286522 @default.
- W1996632693 cites W1982721120 @default.
- W1996632693 cites W1982997073 @default.
- W1996632693 cites W1990714593 @default.
- W1996632693 cites W1991050464 @default.
- W1996632693 cites W1991778005 @default.
- W1996632693 cites W1993791556 @default.
- W1996632693 cites W1995581097 @default.
- W1996632693 cites W1996315754 @default.
- W1996632693 cites W1996705854 @default.
- W1996632693 cites W1999397620 @default.
- W1996632693 cites W2000328098 @default.
- W1996632693 cites W2002371664 @default.
- W1996632693 cites W2003706636 @default.
- W1996632693 cites W2008045899 @default.
- W1996632693 cites W2012898681 @default.
- W1996632693 cites W2013457407 @default.
- W1996632693 cites W2014885387 @default.
- W1996632693 cites W2015192443 @default.
- W1996632693 cites W2015252693 @default.
- W1996632693 cites W2016392966 @default.
- W1996632693 cites W2018047130 @default.
- W1996632693 cites W2020052438 @default.
- W1996632693 cites W2020596370 @default.
- W1996632693 cites W2022167707 @default.
- W1996632693 cites W2026115492 @default.
- W1996632693 cites W2028166367 @default.
- W1996632693 cites W2033961915 @default.
- W1996632693 cites W2034892786 @default.
- W1996632693 cites W2038606768 @default.
- W1996632693 cites W2039614579 @default.
- W1996632693 cites W2044581189 @default.
- W1996632693 cites W2049546396 @default.
- W1996632693 cites W2055606022 @default.
- W1996632693 cites W2064260030 @default.
- W1996632693 cites W2066058647 @default.
- W1996632693 cites W2066502594 @default.
- W1996632693 cites W2072524544 @default.
- W1996632693 cites W2072626592 @default.
- W1996632693 cites W2076987227 @default.
- W1996632693 cites W2077076520 @default.
- W1996632693 cites W2077608891 @default.
- W1996632693 cites W2080087167 @default.
- W1996632693 cites W2084390570 @default.
- W1996632693 cites W2089735209 @default.
- W1996632693 cites W2101206537 @default.
- W1996632693 cites W2104659034 @default.
- W1996632693 cites W2104980609 @default.
- W1996632693 cites W2105995470 @default.
- W1996632693 cites W2117219003 @default.
- W1996632693 cites W2118233257 @default.
- W1996632693 cites W2120539379 @default.
- W1996632693 cites W2123221350 @default.
- W1996632693 cites W2126037960 @default.
- W1996632693 cites W2127478015 @default.
- W1996632693 cites W2131809780 @default.
- W1996632693 cites W2135546546 @default.
- W1996632693 cites W2143401067 @default.
- W1996632693 cites W2152874341 @default.
- W1996632693 cites W2163841453 @default.
- W1996632693 cites W2171638361 @default.
- W1996632693 cites W2171717653 @default.
- W1996632693 cites W2945079589 @default.
- W1996632693 cites W4294062439 @default.
- W1996632693 doi "https://doi.org/10.1016/j.ejphar.2009.10.053" @default.
- W1996632693 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19879868" @default.
- W1996632693 hasPublicationYear "2010" @default.
- W1996632693 type Work @default.
- W1996632693 sameAs 1996632693 @default.
- W1996632693 citedByCount "113" @default.
- W1996632693 countsByYear W19966326932012 @default.
- W1996632693 countsByYear W19966326932013 @default.
- W1996632693 countsByYear W19966326932014 @default.
- W1996632693 countsByYear W19966326932015 @default.
- W1996632693 countsByYear W19966326932016 @default.
- W1996632693 countsByYear W19966326932017 @default.