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- W1996634816 abstract "Abstract In a randomized study the effect of whole blood transfusion versus bedside leucocyte-depleted blood transfusion on lymphocyte proliferation, CD4+: CD8+ratio, and levels of soluble interleukin 2 receptor (sIL-2R) and interleukin (IL) 6, as well as on the development of postoperative wound infection and intra-abdominal abscess, was assessed in 60 patients undergoing elective colorectal surgery. Transfusion with whole blood induced a significant decrease in lymphocyte proliferation and CD4+:CD8+ ratio (P< 0·01) as well as a significant increase in sIL-2R and IL-6 levels (P< 0·01). Furthermore, transfusion with whole blood was accompanied by a significant increase in postoperative infectious complications (P< 0·01). In patients transfused with leucocytedepleted blood only slight and transient changes were observed, which were not significantly different from those observed in non-transfused patients." @default.
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- W1996634816 date "1996-07-01" @default.
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- W1996634816 title "A randomized controlled study of the effect of bedside leucocyte depletion on the immunosuppressive effect of whole blood transfusion in patients undergoing elective colorectal surgery" @default.
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- W1996634816 doi "https://doi.org/10.1002/bjs.1800830727" @default.
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