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• W1996656260 abstract "<h3>Objective</h3> To evaluate the efficacy and safety of combination therapy with acitretin and pioglitazone hydrochloride in patients with moderate to severe chronic plaque-type psoriasis. <h3>Design</h3> Randomized, double-blind, placebo-controlled clinical trial. <h3>Setting</h3> A tertiary care referral hospital. <h3>Patients</h3> The study included patients of either sex (age range, 18-65 years) with moderate to severe chronic plaque-type psoriasis. Patients were excluded if they were of child-bearing potential or if they had impaired liver or renal function, hyperlipidemia, diabetes mellitus, coronary artery disease, or a body mass index greater than 30 (calculated as weight in kilograms divided by height in meters squared). Of the 62 patients screened, 41 were randomly assigned to 2 groups: 22 to an acitretin (25 mg) plus placebo group and 19 to an acitretin (25 mg) plus pioglitazone hydrochloride (15 mg) group. <h3>Main Outcome Measure</h3> Change in Psoriasis Area and Severity Index score between the 2 groups from baseline to 12 weeks. <h3>Results</h3> After 12 weeks of therapy, the percentage of reduction in the Psoriasis Area and Severity Index score was 64.2% in the acitretin plus pioglitazone group and 51.7% in the acitretin plus placebo group. The majority of the adverse events were mild to moderate except for 1 possibly unrelated episode of acute myocardial infarction in a 49-year-old woman in the acitretin plus placebo group. <h3>Conclusions</h3> Pioglitazone has a potential beneficial antipsoriatic effect and may provide a convenient, efficacious, and relatively safe option to combine with acitretin, although further studies are needed. <h3>Trial Registration</h3> clinicaltrials.gov Identifier:NCT00395941" @default.
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• W1996656260 date "2009-04-01" @default.
• W1996656260 modified "2023-10-04" @default.
• W1996656260 title "Efficacy and Safety of Combination Acitretin and Pioglitazone Therapy in Patients With Moderate to Severe Chronic Plaque-Type Psoriasis" @default.
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• W1996656260 doi "https://doi.org/10.1001/archdermatol.2009.5" @default.
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