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- W1996688051 abstract "Dopamine (DA) is released in the medial preoptic area (MPOA) of male rats in the presence of a female, and it facilitates male sexual behavior. Castration blocks the DA response to a female and the male's ability to copulate. The present experiments examined the effects of castration on (1) basal levels of extracellular DA in the MPOA, using the no net flux microdialysis technique, (2) the response of extracellular DA to amphetamine, and (3) tissue levels of DA. Castrated rats had lower basal levels of extracellular DA in the MPOA, compared with gonadally intact rats; in vivo recovery, a measure of uptake, was not different. This suggests that castration decreases DA release in basal conditions, as well as in response to a female. However, systemic amphetamine injections, which induce DA release, resulted in greater DA release in castrates. Finally, tissue levels of DA were higher in the MPOA, the caudate–putamen and the bed nucleus of stria terminalis of castrates. These data suggest that DA synthesis and storage in the MPOA are normal, or even enhanced, in castrates, and uptake is not altered. The deficit in extracellular levels appears to be related to release, perhaps due to decreased nitric oxide." @default.
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- W1996688051 date "1998-01-01" @default.
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- W1996688051 title "Castration decreases extracellular, but increases intracellular, dopamine in medial preoptic area of male rats" @default.
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- W1996688051 doi "https://doi.org/10.1016/s0006-8993(97)01144-x" @default.
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