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- W1996688417 abstract "Studies have been carried out to determine the effects of prophylactic treatment with P2S (1-methyl,2-hydroxyinimomethylpyridinium methanesulfonate) on the survival of animals poisoned by lethal doses of sarin, soman, tabun, or VX (O-ethyl S-diisopropylaminoethyl methylphosphonothiolate). The influence of such prophylaxis on the efficacy of therapy with atropine and P2S after poisoning by the same organophosphates has also been investigated. Following pretreatment with P2S there was a significant increase, compared with control animals, in the survival time of rabbits and guinea pigs poisoned by 2.3 LD50 of sarin and VX. With soman and tabun, the increase in the time of survival was slight, but consistent. In every case, the time taken for signs of poisoning to occur was unaffected by the pretreatment. P2S prophylaxis enhanced the effectiveness of therapy with atropine, and P2S given after poisoning with organophosphates had a similar effect, although the extent of the protection against soman poisoning was considerably less than that achieved against poisoning by sarin or VX." @default.
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- W1996688417 date "1977-04-01" @default.
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- W1996688417 title "The prophylactic use of 1-methyl, 2-hydroxyiminomethylpyridinium methanesulfonate (P2S) in the treatment of organophosphate poisoning" @default.
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- W1996688417 doi "https://doi.org/10.1016/0041-008x(77)90122-3" @default.
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