FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996703105> ?p ?o ?g. }

• W1996703105 endingPage "68" @default.
• W1996703105 startingPage "58" @default.
• W1996703105 abstract "Fundus autofluorescence (AF) imaging by confocal scanning laser ophthalmoscopy has been widely used by ophthalmologists in the diagnosis/monitoring of various retinal disorders. It is believed that fundus AF is derived from lipofuscin in retinal pigment epithelial (RPE) cells; however, direct clinicopathological correlation has not been possible in humans. We examined fundus AF by confocal scanning laser ophthalmoscopy and confocal microscopy in normal C57BL/6 mice of different ages. Increasingly strong AF signals were observed with age in the neuroretina and subretinal/RPE layer by confocal scanning laser ophthalmoscopy. Unlike fundus AF detected in normal human subjects, mouse fundus AF appeared as discrete foci distributed throughout the retina. Most of the AF signals in the neuroretina were distributed around retinal vessels. Confocal microscopy of retinal and choroid/RPE flat mounts demonstrated that most of the AF signals were derived from Iba-1+ perivascular and subretinal microglia. An age-dependent accumulation of Iba-1+ microglia at the subretinal space was observed. Lipofuscin granules were detected in large numbers in subretinal microglia by electron microscopy. The number of AF+ microglia and the amount of AF granules/cell increased with age. AF granules/lipofuscin were also observed in RPE cells in mice older than 12 months, but the number of AF+ RPE cells was very low (1.48 mm−2 and 5.02 mm−2 for 12 and 24 months, respectively) compared to the number of AF+ microglial cells (20.63 mm−2 and 76.36 mm−2 for 6 and 24 months, respectively). The fluorescence emission fingerprints of AF granules in subretinal microglia were the same as those in RPE cells. Our observation suggests that perivascular and subretinal microglia are the main cells producing lipofuscin in normal aged mouse retina and are responsible for in vivo fundus AF. Microglia may play an important role in retinal aging and age-related retinal diseases." @default.
• W1996703105 created "2016-06-24" @default.
• W1996703105 creator A5002210515 @default.
• W1996703105 creator A5027358797 @default.
• W1996703105 creator A5046784348 @default.
• W1996703105 creator A5076206267 @default.
• W1996703105 creator A5090676693 @default.
• W1996703105 date "2008-02-01" @default.
• W1996703105 modified "2023-10-16" @default.
• W1996703105 title "Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice" @default.
• W1996703105 cites W1538904872 @default.
• W1996703105 cites W1539394488 @default.
• W1996703105 cites W1796224740 @default.
• W1996703105 cites W1963653572 @default.
• W1996703105 cites W1974007609 @default.
• W1996703105 cites W1977760393 @default.
• W1996703105 cites W1979276409 @default.
• W1996703105 cites W1980973795 @default.
• W1996703105 cites W1989558725 @default.
• W1996703105 cites W1996070625 @default.
• W1996703105 cites W1996550094 @default.
• W1996703105 cites W2024215142 @default.
• W1996703105 cites W2033409310 @default.
• W1996703105 cites W2037760636 @default.
• W1996703105 cites W2042162229 @default.
• W1996703105 cites W2044878909 @default.
• W1996703105 cites W2045180417 @default.
• W1996703105 cites W2046608494 @default.
• W1996703105 cites W2046637570 @default.
• W1996703105 cites W2049199904 @default.
• W1996703105 cites W2050878478 @default.
• W1996703105 cites W2053176712 @default.
• W1996703105 cites W2059407358 @default.
• W1996703105 cites W2061947049 @default.
• W1996703105 cites W2070149670 @default.
• W1996703105 cites W2076758633 @default.
• W1996703105 cites W2078901795 @default.
• W1996703105 cites W2079645604 @default.
• W1996703105 cites W2087038112 @default.
• W1996703105 cites W2090450669 @default.
• W1996703105 cites W2092203818 @default.
• W1996703105 cites W2093514833 @default.
• W1996703105 cites W2098997817 @default.
• W1996703105 cites W2102346943 @default.
• W1996703105 cites W2102445483 @default.
• W1996703105 cites W2114029080 @default.
• W1996703105 cites W2115660235 @default.
• W1996703105 cites W2133889213 @default.
• W1996703105 cites W2169437717 @default.
• W1996703105 cites W2171381331 @default.
• W1996703105 cites W2171817800 @default.
• W1996703105 cites W2172112177 @default.
• W1996703105 doi "https://doi.org/10.1111/j.1474-9726.2007.00351.x" @default.
• W1996703105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17988243" @default.
• W1996703105 hasPublicationYear "2008" @default.
• W1996703105 type Work @default.
• W1996703105 sameAs 1996703105 @default.
• W1996703105 citedByCount "225" @default.
• W1996703105 countsByYear W19967031052012 @default.
• W1996703105 countsByYear W19967031052013 @default.
• W1996703105 countsByYear W19967031052014 @default.
• W1996703105 countsByYear W19967031052015 @default.
• W1996703105 countsByYear W19967031052016 @default.
• W1996703105 countsByYear W19967031052017 @default.
• W1996703105 countsByYear W19967031052018 @default.
• W1996703105 countsByYear W19967031052019 @default.
• W1996703105 countsByYear W19967031052020 @default.
• W1996703105 countsByYear W19967031052021 @default.
• W1996703105 countsByYear W19967031052022 @default.
• W1996703105 countsByYear W19967031052023 @default.
• W1996703105 crossrefType "journal-article" @default.
• W1996703105 hasAuthorship W1996703105A5002210515 @default.
• W1996703105 hasAuthorship W1996703105A5027358797 @default.
• W1996703105 hasAuthorship W1996703105A5046784348 @default.
• W1996703105 hasAuthorship W1996703105A5076206267 @default.
• W1996703105 hasAuthorship W1996703105A5090676693 @default.
• W1996703105 hasConcept C105702510 @default.
• W1996703105 hasConcept C118487528 @default.
• W1996703105 hasConcept C120665830 @default.
• W1996703105 hasConcept C121332964 @default.
• W1996703105 hasConcept C136009344 @default.
• W1996703105 hasConcept C142724271 @default.
• W1996703105 hasConcept C169760540 @default.
• W1996703105 hasConcept C179687394 @default.
• W1996703105 hasConcept C186198217 @default.
• W1996703105 hasConcept C203014093 @default.
• W1996703105 hasConcept C2776391266 @default.
• W1996703105 hasConcept C2776914184 @default.
• W1996703105 hasConcept C2777093970 @default.
• W1996703105 hasConcept C2777474606 @default.
• W1996703105 hasConcept C2778024200 @default.
• W1996703105 hasConcept C2779178360 @default.
• W1996703105 hasConcept C2779830541 @default.
• W1996703105 hasConcept C2780623050 @default.
• W1996703105 hasConcept C2780827179 @default.
• W1996703105 hasConcept C55493867 @default.
• W1996703105 hasConcept C71924100 @default.
• W1996703105 hasConcept C86803240 @default.

• next