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- W1996703358 abstract "ABSTRACT − The purpose of this study was to evaluate the phagocytic uptake of surface modified PLGA microspherescontaining ovalbumin (OVA) into dendritic cell. In order to find the most suitable formulation for targeted delivery to anti-gen presenting cells (APC), OVA was encapsulated by a double emulsion solvent evaporation method with three PLGAmicrospheres (PLGA 50:50, PLGA 75:25 and PLGA 85:15) and two surface modified microspheres by chitosan and sodiumdodecyl sulfate (SDS). Physicochemical properties were evaluated in terms of size, zeta potential, encapsulation efficiency,different scanning calorimeter (DSC), x-ray diffraction, morphology, and OVA release test from microspheres. Phagocyticactivity was estimated using dendritic cells and analyzed by fluorescence activated cell sorter (FACS). The result showedthat zeta potential of PLGA particles was changed to positive by the chitosan modification. The release profile of chitosanmodified PLGA microspheres exhibited sustained release after initial burst. The chitosan modified microspheres had higherphagocytic uptake than the other microspheres. Such physicochemical properties and phagocytic uptake studies lead us toconclude that chitosan modified microspheres is more suitable formulation for the targeted delivery of antigens to APC com-pared with the other microspheres.Key words" @default.
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- W1996703358 date "2011-06-20" @default.
- W1996703358 modified "2023-09-25" @default.
- W1996703358 title "Phagocytic Uptake of Surface modified PLGA Microspheres Using Dendritic Cell" @default.
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- W1996703358 doi "https://doi.org/10.4333/kps.2011.41.3.185" @default.
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