FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996703871> ?p ?o ?g. }

• W1996703871 endingPage "4079" @default.
• W1996703871 startingPage "4079" @default.
• W1996703871 abstract "To study matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinases (TIMP) in the corneas from mice with ulcerative herpes stromal keratitis (HSK) treated with amniotic membrane transplantation (AMT).The corneas from BALB/c mice were infected with HSV-1. Mice with ulcerative HSK on postinfection (PI) day 14 were used for the experiments. In one group of mice, the corneas were treated with transplantation of amniotic membrane (AMT) that was secured with a tarsorrhaphy, and a control group underwent tarsorrhaphy alone. After 2 days, the appearance of corneal ulcers and stromal inflammation was judged clinically. Corneal sections were studied by immunohistochemistry for the expression of MMP-2, -8, and -9 and TIMP-1 and -2. MMP activity in the corneas was investigated by zymography, and the expression of the enzymes was measured by the Western blot technique.At day 14 PI, the ulcers stained intensely positive for MMP-2, -8, and -9 and TIMP-1 and -2. Ulceration (P < 0.001), stromal inflammation (P < 0.01) and inflammatory cell infiltration (P < 0.001) markedly improved by day 2 after AMT. This was associated with reduced expression (P < 0.01) and activity of MMP-8, and -9 and increased localization of TIMP-1 (P < 0.01), whereas TIMP-2 was not affected. In contrast, high levels of expression of MMP-8 and -9 remained in the cornea after tarsorrhaphy, and the TIMP-1 expression was only slightly upregulated.Rapid improvement of HSV-1-induced ulcerative keratitis is noted after amniotic membrane transplantation. This may be caused by reduced expression and activity of MMP-8 and -9, increased expression of TIMP-1, and sustained expression of TIMP-2." @default.
• W1996703871 created "2016-06-24" @default.
• W1996703871 creator A5005116805 @default.
• W1996703871 creator A5038688388 @default.
• W1996703871 creator A5043985840 @default.
• W1996703871 creator A5047285347 @default.
• W1996703871 creator A5056166927 @default.
• W1996703871 creator A5064342499 @default.
• W1996703871 date "2005-11-01" @default.
• W1996703871 modified "2023-10-01" @default.
• W1996703871 title "Transplantation of Amniotic Membrane in Murine Herpes Stromal Keratitis Modulates Matrix Metalloproteinases in the Cornea" @default.
• W1996703871 cites W128791414 @default.
• W1996703871 cites W148052990 @default.
• W1996703871 cites W1491678226 @default.
• W1996703871 cites W1553817667 @default.
• W1996703871 cites W1577568758 @default.
• W1996703871 cites W1584286177 @default.
• W1996703871 cites W1607189030 @default.
• W1996703871 cites W1642011778 @default.
• W1996703871 cites W1743570032 @default.
• W1996703871 cites W1964947801 @default.
• W1996703871 cites W1980480613 @default.
• W1996703871 cites W1984896204 @default.
• W1996703871 cites W1986860180 @default.
• W1996703871 cites W1988419379 @default.
• W1996703871 cites W1992495439 @default.
• W1996703871 cites W2002314341 @default.
• W1996703871 cites W2003879470 @default.
• W1996703871 cites W2008058658 @default.
• W1996703871 cites W2010775875 @default.
• W1996703871 cites W2025121277 @default.
• W1996703871 cites W2029840653 @default.
• W1996703871 cites W2034780538 @default.
• W1996703871 cites W2038613403 @default.
• W1996703871 cites W2048280907 @default.
• W1996703871 cites W2048714509 @default.
• W1996703871 cites W2054103621 @default.
• W1996703871 cites W2057440281 @default.
• W1996703871 cites W2065069982 @default.
• W1996703871 cites W2065624075 @default.
• W1996703871 cites W2069957290 @default.
• W1996703871 cites W2091616446 @default.
• W1996703871 cites W2093931068 @default.
• W1996703871 cites W2116254213 @default.
• W1996703871 cites W2116484695 @default.
• W1996703871 cites W2117611251 @default.
• W1996703871 cites W2127182319 @default.
• W1996703871 cites W2144743138 @default.
• W1996703871 cites W2401031592 @default.
• W1996703871 cites W4233729 @default.
• W1996703871 cites W52243265 @default.
• W1996703871 cites W59316791 @default.
• W1996703871 cites W88741246 @default.
• W1996703871 doi "https://doi.org/10.1167/iovs.05-0192" @default.
• W1996703871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16249483" @default.
• W1996703871 hasPublicationYear "2005" @default.
• W1996703871 type Work @default.
• W1996703871 sameAs 1996703871 @default.
• W1996703871 citedByCount "45" @default.
• W1996703871 countsByYear W19967038712012 @default.
• W1996703871 countsByYear W19967038712013 @default.
• W1996703871 countsByYear W19967038712015 @default.
• W1996703871 countsByYear W19967038712016 @default.
• W1996703871 countsByYear W19967038712017 @default.
• W1996703871 countsByYear W19967038712018 @default.
• W1996703871 countsByYear W19967038712019 @default.
• W1996703871 countsByYear W19967038712020 @default.
• W1996703871 countsByYear W19967038712021 @default.
• W1996703871 countsByYear W19967038712022 @default.
• W1996703871 countsByYear W19967038712023 @default.
• W1996703871 crossrefType "journal-article" @default.
• W1996703871 hasAuthorship W1996703871A5005116805 @default.
• W1996703871 hasAuthorship W1996703871A5038688388 @default.
• W1996703871 hasAuthorship W1996703871A5043985840 @default.
• W1996703871 hasAuthorship W1996703871A5047285347 @default.
• W1996703871 hasAuthorship W1996703871A5056166927 @default.
• W1996703871 hasAuthorship W1996703871A5064342499 @default.
• W1996703871 hasConcept C109523444 @default.
• W1996703871 hasConcept C118487528 @default.
• W1996703871 hasConcept C126322002 @default.
• W1996703871 hasConcept C141071460 @default.
• W1996703871 hasConcept C142724271 @default.
• W1996703871 hasConcept C16930146 @default.
• W1996703871 hasConcept C177430391 @default.
• W1996703871 hasConcept C2776882836 @default.
• W1996703871 hasConcept C2778560704 @default.
• W1996703871 hasConcept C2780686511 @default.
• W1996703871 hasConcept C2911091166 @default.
• W1996703871 hasConcept C71924100 @default.
• W1996703871 hasConceptScore W1996703871C109523444 @default.
• W1996703871 hasConceptScore W1996703871C118487528 @default.
• W1996703871 hasConceptScore W1996703871C126322002 @default.
• W1996703871 hasConceptScore W1996703871C141071460 @default.
• W1996703871 hasConceptScore W1996703871C142724271 @default.
• W1996703871 hasConceptScore W1996703871C16930146 @default.
• W1996703871 hasConceptScore W1996703871C177430391 @default.
• W1996703871 hasConceptScore W1996703871C2776882836 @default.
• W1996703871 hasConceptScore W1996703871C2778560704 @default.

• next