FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996706043> ?p ?o ?g. }

• W1996706043 endingPage "537" @default.
• W1996706043 startingPage "528" @default.
• W1996706043 abstract "Recombinant adeno-associated viral (AAV) vectors can transduce cells of the CNS, resulting in long-term expression. AAV vector transduction varies depending on the serotype used and the region of the brain injected. AAV serotypes 7, 8, 9, and Rh10 have recently become available, but the transduction capabilities of these serotypes within the CNS have not been determined. We show that AAV 7, 8, 9, and Rh10 vectors expressing cDNA for a lysosomal enzyme transduce neurons, but not astrocytes or oligodendrocytes, in the cortex, striatum, hippocampus, and thalamus. Although all of the vectors contained the same genome, there were markedly different transduction patterns that could be due only to the differences in capsid proteins. The AAV 9 vector was found to undergo vector genome transport to distal neuronal cell bodies via known axonal pathways. This facilitated the distribution of enzyme, resulting in correction of lysosomal storage lesions in regions of a diseased brain that would not be corrected if the genome were not transported." @default.
• W1996706043 created "2016-06-24" @default.
• W1996706043 creator A5013856846 @default.
• W1996706043 creator A5049845049 @default.
• W1996706043 date "2006-03-01" @default.
• W1996706043 modified "2023-10-01" @default.
• W1996706043 title "Transduction characteristics of adeno-associated virus vectors expressing cap serotypes 7, 8, 9, and Rh10 in the mouse brain" @default.
• W1996706043 cites W1601499949 @default.
• W1996706043 cites W1963623233 @default.
• W1996706043 cites W1972747973 @default.
• W1996706043 cites W1974003614 @default.
• W1996706043 cites W1983282437 @default.
• W1996706043 cites W1984959384 @default.
• W1996706043 cites W1994726707 @default.
• W1996706043 cites W2000725549 @default.
• W1996706043 cites W2003456064 @default.
• W1996706043 cites W2007105697 @default.
• W1996706043 cites W2016390889 @default.
• W1996706043 cites W2034364510 @default.
• W1996706043 cites W2035507981 @default.
• W1996706043 cites W2037490639 @default.
• W1996706043 cites W2047608515 @default.
• W1996706043 cites W2050245606 @default.
• W1996706043 cites W2063049455 @default.
• W1996706043 cites W2073010549 @default.
• W1996706043 cites W2073304593 @default.
• W1996706043 cites W2078976766 @default.
• W1996706043 cites W2080408702 @default.
• W1996706043 cites W2081694771 @default.
• W1996706043 cites W2100829186 @default.
• W1996706043 cites W2116126342 @default.
• W1996706043 cites W2164453107 @default.
• W1996706043 cites W2166736363 @default.
• W1996706043 cites W4234505218 @default.
• W1996706043 cites W4245307762 @default.
• W1996706043 cites W4247717176 @default.
• W1996706043 doi "https://doi.org/10.1016/j.ymthe.2005.11.015" @default.
• W1996706043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16413228" @default.
• W1996706043 hasPublicationYear "2006" @default.
• W1996706043 type Work @default.
• W1996706043 sameAs 1996706043 @default.
• W1996706043 citedByCount "331" @default.
• W1996706043 countsByYear W19967060432012 @default.
• W1996706043 countsByYear W19967060432013 @default.
• W1996706043 countsByYear W19967060432014 @default.
• W1996706043 countsByYear W19967060432015 @default.
• W1996706043 countsByYear W19967060432016 @default.
• W1996706043 countsByYear W19967060432017 @default.
• W1996706043 countsByYear W19967060432018 @default.
• W1996706043 countsByYear W19967060432019 @default.
• W1996706043 countsByYear W19967060432020 @default.
• W1996706043 countsByYear W19967060432021 @default.
• W1996706043 countsByYear W19967060432022 @default.
• W1996706043 countsByYear W19967060432023 @default.
• W1996706043 crossrefType "journal-article" @default.
• W1996706043 hasAuthorship W1996706043A5013856846 @default.
• W1996706043 hasAuthorship W1996706043A5049845049 @default.
• W1996706043 hasBestOaLocation W19967060431 @default.
• W1996706043 hasConcept C104317684 @default.
• W1996706043 hasConcept C15152581 @default.
• W1996706043 hasConcept C153911025 @default.
• W1996706043 hasConcept C159047783 @default.
• W1996706043 hasConcept C187882448 @default.
• W1996706043 hasConcept C202878990 @default.
• W1996706043 hasConcept C2522874641 @default.
• W1996706043 hasConcept C2778107364 @default.
• W1996706043 hasConcept C32470452 @default.
• W1996706043 hasConcept C40767141 @default.
• W1996706043 hasConcept C54355233 @default.
• W1996706043 hasConcept C55493867 @default.
• W1996706043 hasConcept C86803240 @default.
• W1996706043 hasConcept C92087593 @default.
• W1996706043 hasConcept C95444343 @default.
• W1996706043 hasConceptScore W1996706043C104317684 @default.
• W1996706043 hasConceptScore W1996706043C15152581 @default.
• W1996706043 hasConceptScore W1996706043C153911025 @default.
• W1996706043 hasConceptScore W1996706043C159047783 @default.
• W1996706043 hasConceptScore W1996706043C187882448 @default.
• W1996706043 hasConceptScore W1996706043C202878990 @default.
• W1996706043 hasConceptScore W1996706043C2522874641 @default.
• W1996706043 hasConceptScore W1996706043C2778107364 @default.
• W1996706043 hasConceptScore W1996706043C32470452 @default.
• W1996706043 hasConceptScore W1996706043C40767141 @default.
• W1996706043 hasConceptScore W1996706043C54355233 @default.
• W1996706043 hasConceptScore W1996706043C55493867 @default.
• W1996706043 hasConceptScore W1996706043C86803240 @default.
• W1996706043 hasConceptScore W1996706043C92087593 @default.
• W1996706043 hasConceptScore W1996706043C95444343 @default.
• W1996706043 hasIssue "3" @default.
• W1996706043 hasLocation W19967060431 @default.
• W1996706043 hasLocation W19967060432 @default.
• W1996706043 hasOpenAccess W1996706043 @default.
• W1996706043 hasPrimaryLocation W19967060431 @default.
• W1996706043 hasRelatedWork W1996746326 @default.
• W1996706043 hasRelatedWork W2052489850 @default.
• W1996706043 hasRelatedWork W2066051128 @default.
• W1996706043 hasRelatedWork W2084114153 @default.
• W1996706043 hasRelatedWork W2377458113 @default.

• next