FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996706763> ?p ?o ?g. }

• W1996706763 endingPage "2481" @default.
• W1996706763 startingPage "2471" @default.
• W1996706763 abstract "Abstract Lymphatic spread is an important clinical determinant for the prognosis of hepatocellular carcinoma (HCC), but little is known about the control of lymphangiogenesis in HCC. We addressed expression and biological role of the pro‐(lymph), angiogenic protein VEGF‐D in this tumor entity. Using immunohistochemistry and in situ hybridization on specimens of HCC, cirrhotic and normal liver we found abundant expression of VEGF‐D exclusively in the tumor cells. The cognate receptor VEGFR‐3 was detected on blood and lymphatic vessels. By clinicopathological analysis VEGF‐D expression was correlated with pT‐stage of the primary, lymph node metastasis and lymphangiosis carcinomatosa. Three out of 4 human HCC cell lines expressed and secreted VEGF‐D. To approach its biological function, VEGF‐D deficient SKHep‐1 cells were stably transfected with VEGF‐D cDNA and effects on tumor progression were determined in vivo . Compared to mock‐transfected controls, subcutaneous tumors derived from VEGF‐D expressing cells were larger and more frequently metastasized to regional lymph nodes. VEGF‐D expressing tumors exhibited increased microvessel density and increased abundance of peri‐ and intratumoral lymphatics, as assessed by immunostaining for CD31 and for LYVE‐1 and/or podoplanin, respectively. Furthermore, coexpression of the soluble extracellular VEGFR‐3 domain blocked VEGF‐D‐induced tumor growth and lymphatic spread via reduction of angiogenesis and lymphangiogenesis. In the orthotopic approach, VEGF‐D expression resulted in an increased rate of intra‐ and extrahepatic as well as lymph node metastasis. In conclusion, our study suggests that expression of VEGF‐D is involved in growth and lymphatic spread of HCC. Therefore, VEGF‐D might represent a therapeutic target in HCC. © 2008 Wiley‐Liss, Inc." @default.
• W1996706763 created "2016-06-24" @default.
• W1996706763 creator A5007891817 @default.
• W1996706763 creator A5009812512 @default.
• W1996706763 creator A5030045751 @default.
• W1996706763 creator A5030057178 @default.
• W1996706763 creator A5032379092 @default.
• W1996706763 creator A5040837927 @default.
• W1996706763 creator A5044565481 @default.
• W1996706763 creator A5048514324 @default.
• W1996706763 creator A5072037129 @default.
• W1996706763 date "2008-03-13" @default.
• W1996706763 modified "2023-10-18" @default.
• W1996706763 title "VEGF-D promotes tumor growth and lymphatic spread in a mouse model of hepatocellular carcinoma" @default.
• W1996706763 cites W1518093405 @default.
• W1996706763 cites W1519030262 @default.
• W1996706763 cites W1578283200 @default.
• W1996706763 cites W1974097718 @default.
• W1996706763 cites W1994638693 @default.
• W1996706763 cites W2000375890 @default.
• W1996706763 cites W2003450086 @default.
• W1996706763 cites W2006298485 @default.
• W1996706763 cites W2025173623 @default.
• W1996706763 cites W2025933554 @default.
• W1996706763 cites W2034819626 @default.
• W1996706763 cites W2039114719 @default.
• W1996706763 cites W2049424656 @default.
• W1996706763 cites W2050618337 @default.
• W1996706763 cites W2051421411 @default.
• W1996706763 cites W2069828593 @default.
• W1996706763 cites W2073704598 @default.
• W1996706763 cites W2079954571 @default.
• W1996706763 cites W2118282739 @default.
• W1996706763 cites W2120614448 @default.
• W1996706763 cites W2129081579 @default.
• W1996706763 cites W2147186052 @default.
• W1996706763 cites W2147742546 @default.
• W1996706763 cites W2155591311 @default.
• W1996706763 cites W2159241628 @default.
• W1996706763 cites W2164738538 @default.
• W1996706763 cites W2164757740 @default.
• W1996706763 cites W2167328332 @default.
• W1996706763 cites W2171543828 @default.
• W1996706763 cites W2346857231 @default.
• W1996706763 cites W248861484 @default.
• W1996706763 cites W4230897222 @default.
• W1996706763 cites W4250428608 @default.
• W1996706763 cites W4362203923 @default.
• W1996706763 doi "https://doi.org/10.1002/ijc.23439" @default.
• W1996706763 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18338756" @default.
• W1996706763 hasPublicationYear "2008" @default.
• W1996706763 type Work @default.
• W1996706763 sameAs 1996706763 @default.
• W1996706763 citedByCount "58" @default.
• W1996706763 countsByYear W19967067632012 @default.
• W1996706763 countsByYear W19967067632013 @default.
• W1996706763 countsByYear W19967067632014 @default.
• W1996706763 countsByYear W19967067632015 @default.
• W1996706763 countsByYear W19967067632016 @default.
• W1996706763 countsByYear W19967067632017 @default.
• W1996706763 countsByYear W19967067632018 @default.
• W1996706763 countsByYear W19967067632019 @default.
• W1996706763 countsByYear W19967067632020 @default.
• W1996706763 countsByYear W19967067632021 @default.
• W1996706763 countsByYear W19967067632022 @default.
• W1996706763 countsByYear W19967067632023 @default.
• W1996706763 crossrefType "journal-article" @default.
• W1996706763 hasAuthorship W1996706763A5007891817 @default.
• W1996706763 hasAuthorship W1996706763A5009812512 @default.
• W1996706763 hasAuthorship W1996706763A5030045751 @default.
• W1996706763 hasAuthorship W1996706763A5030057178 @default.
• W1996706763 hasAuthorship W1996706763A5032379092 @default.
• W1996706763 hasAuthorship W1996706763A5040837927 @default.
• W1996706763 hasAuthorship W1996706763A5044565481 @default.
• W1996706763 hasAuthorship W1996706763A5048514324 @default.
• W1996706763 hasAuthorship W1996706763A5072037129 @default.
• W1996706763 hasBestOaLocation W19967067631 @default.
• W1996706763 hasConcept C121608353 @default.
• W1996706763 hasConcept C126322002 @default.
• W1996706763 hasConcept C142724271 @default.
• W1996706763 hasConcept C181152851 @default.
• W1996706763 hasConcept C204232928 @default.
• W1996706763 hasConcept C2776636583 @default.
• W1996706763 hasConcept C2778019345 @default.
• W1996706763 hasConcept C2778939058 @default.
• W1996706763 hasConcept C2779013556 @default.
• W1996706763 hasConcept C2779720271 @default.
• W1996706763 hasConcept C2780394083 @default.
• W1996706763 hasConcept C2780849966 @default.
• W1996706763 hasConcept C2780965494 @default.
• W1996706763 hasConcept C2910366181 @default.
• W1996706763 hasConcept C502942594 @default.
• W1996706763 hasConcept C71924100 @default.
• W1996706763 hasConcept C86803240 @default.
• W1996706763 hasConceptScore W1996706763C121608353 @default.
• W1996706763 hasConceptScore W1996706763C126322002 @default.
• W1996706763 hasConceptScore W1996706763C142724271 @default.
• W1996706763 hasConceptScore W1996706763C181152851 @default.

• next