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- W1996708908 abstract "Primary astrocyte cultures from newborn rats were exposed to two model solvents, one chlorinated hydrocarbon (carbon tetrachloride) and one aliphatic hydrocarbon (n-hexane), for 1 hr in a closed chamber system. Both solvents caused a reduction in basal oxygen consumption by approximately 40%. Glutamate-stimulated respiration was reduced to a similar extent. Carbon tetrachloride caused a 100% increase and a 50% decrease, respectively, in the potassium- and A2 receptor-mediated elevation in cAMP levels. On the other hand, n-hexane affected only the basal level of cAMP, causing an eight-fold increase. These results indicate that carbon tetrachloride and n-hexane may interfere with essential astrocyte functions." @default.
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- W1996708908 date "1991-01-01" @default.
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- W1996708908 title "Astrocytic regulatory functions: A possible target for CNS effects of organic solvents" @default.
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- W1996708908 doi "https://doi.org/10.1016/0887-2333(91)90081-n" @default.
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