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• W1996709214 abstract "The cellular prion protein (PrPC) is a neuronal-anchored glycoprotein that has been associated with various functions in the CNS such as synaptic plasticity, cognitive processes and neuroprotection. Here we investigated age-related behavioral and neurochemical alterations in wild-type (Prnp+/+), PrPC knockout (Prnp0/0) and the PrPC overexpressing Tg-20 mice. Three- or 11 month-old animals were submitted to a battery of behavioral tasks including open field, activity cages, elevated plus-maze, social recognition and inhibitory avoidance tasks. The 11 month-old Prnp+/+ and Prnp0/0 mice exhibited significant impairments in their locomotor activity and social recognition memory and increased anxiety-related responses. Remarkably, Tg-20 mice did not present these age-related impairments. The i.c.v. infusion of STI1 peptide 230–245, which includes the PrPC binding site, improved the age-related social recognition deficits in Prnp+/+. In comparison with the two other age-matched genotypes, the 11 month-old Tg-20 mice also exhibited reduced activity of seric acetylcholinesterase, increased expression of the protein synaptophysin and decreased caspase-3 positive-cells in the hippocampus. The present findings obtained with genetic and pharmacological approaches provide convincing evidence that PrPC exerts a critical role in the age-related behavioral deficits in mice probably through adaptive mechanisms including apoptotic pathways and synaptic plasticity." @default.
• W1996709214 created "2016-06-24" @default.
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• W1996709214 date "2009-12-01" @default.
• W1996709214 modified "2023-10-16" @default.
• W1996709214 title "Cellular prion protein modulates age-related behavioral and neurochemical alterations in mice" @default.
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• W1996709214 doi "https://doi.org/10.1016/j.neuroscience.2009.09.005" @default.
• W1996709214 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19747526" @default.
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