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• W1996710557 startingPage "4171" @default.
• W1996710557 abstract "Attempts to stimulate therapeutic angiogenesis using gene therapy or delivery of recombinant growth factors, such as vascular endothelial growth factor (VEGF), have failed to demonstrate unequivocal efficacy in human trials. Bioactive glass stimulates fibroblasts to secrete significantly increased amounts of angiogenic growth factors and therefore has a number of potential applications in therapeutic angiogenesis. The aim of this study was to assess whether it is possible to encapsulate specific quantities of bioactive glass and fibroblasts into alginate beads, which will secrete growth factors capable of stimulating angiogenesis. Human fibroblasts (CCD-18Co) were encapsulated in alginate beads with specific quantities of 45S5 bioactive glass and incubated in culture medium (0–17 days). The conditioned medium was collected and assayed for VEGF or used to assess its ability to stimulate angiogenesis by measuring the proliferation of human dermal microvascular endothelial cells. At 17 days the beads were lysed and the amount of VEGF retained by the beads measured. Fibroblasts encapsulated in alginate beads containing 0.01% and 0.1% (w/v) 45S5 bioactive glass particles secreted increased quantities of VEGF compared with cells encapsulated with 0% or 1% (w/v) 45S5 bioactive glass particles. Lysed alginate beads containing 0.01% and 0.1% (w/v) 45S5 bioactive glass contained significantly more VEGF (p<0.01) compared with beads containing no glass particles. Endothelial cell proliferation was significantly increased (p<0.01) by conditioned medium collected from alginate beads containing 0.1% (w/v) 45S5 bioactive glass particles. The results of this study demonstrate that bioactive glass and fibroblasts can be successfully incorporated into alginate beads for use in delivering angiogenic growth factors. With further optimization, this technique offers a novel delivery device for stimulating therapeutic angiogenesis." @default.
• W1996710557 created "2016-06-24" @default.
• W1996710557 creator A5003280129 @default.
• W1996710557 creator A5038221938 @default.
• W1996710557 creator A5066411115 @default.
• W1996710557 date "2005-07-01" @default.
• W1996710557 modified "2023-10-16" @default.
• W1996710557 title "Release of angiogenic growth factors from cells encapsulated in alginate beads with bioactive glass" @default.
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• W1996710557 doi "https://doi.org/10.1016/j.biomaterials.2004.10.021" @default.
• W1996710557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15664644" @default.
• W1996710557 hasPublicationYear "2005" @default.
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